scholarly journals Second malignant neoplasms among children, adolescents and young adults with Wilms tumor

2015 ◽  
Vol 62 (7) ◽  
pp. 1259-1264 ◽  
Author(s):  
Jean S. Lee ◽  
Benjamin Padilla ◽  
Steven G. DuBois ◽  
Aris Oates ◽  
John Boscardin ◽  
...  
Keyword(s):  
Young Adults ◽  
Wilms Tumor ◽  
Adolescents And Young Adults ◽  
Malignant Neoplasms ◽  
Second Malignant Neoplasms

scholarly journals Increased risk of second malignant neoplasms in adolescents and young adults with cancer

Cancer ◽  
2015 ◽  
Vol 122 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Jean S. Lee ◽  
Steven G. DuBois ◽  
Peter F. Coccia ◽  
Archie Bleyer ◽  
Rebecca L. Olin ◽  
...  
Keyword(s):  
Young Adults ◽  
Adolescents And Young Adults ◽  
Malignant Neoplasms ◽  
Increased Risk ◽  
Second Malignant Neoplasms

Second malignant neoplasms in children: an update from the Late Effects Study Group.

1985 ◽  
Vol 3 (4) ◽  
pp. 532-538 ◽  
Author(s):  
A T Meadows ◽  
E Baum ◽  
F Fossati-Bellani ◽  
D Green ◽  
R D Jenkin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Late Effects ◽  
Wilms Tumor ◽  
Soft Tissue Sarcomas ◽  
Malignant Neoplasms ◽  
Study Group ◽  
Second Malignant Neoplasms ◽  
Bone Sarcomas ◽  
Radiation Genetic ◽  
Survivors Of Childhood Cancer

This paper presents an update from the Late Effects Study Group on 292 cases of second malignant neoplasms (SMN) occurring in individuals who were diagnosed with their first neoplasm in childhood. Data are presented regarding the types of first and second neoplasm, the therapy administered, and the predisposing factors. Of the 292 cases (308 SMN), the most common primary was retinoblastoma followed by Hodgkin's disease, soft-tissue sarcomas, and Wilms' tumor. This is not similar to the relative frequency of these cancers in children but rather reflects specific risk factors. Bone sarcomas were the most common SMN among the 208 SMN developing in previously irradiated sites while acute leukemia was the most common SMN unassociated with radiation. Known predisposing conditions to cancer were present in 73 cases; retinoblastoma was the most common of these, followed by neurofibromatosis. There were ten patients with three and three patients with four malignant neoplasms. In 14 patients, the cause of SMN was not suggested by known risk factors as these patients had negative family histories and received no radiation or chemotherapy. We note, therefore, that although most cases of SMN in survivors of childhood cancer can be attributed to radiation, genetic disease, chemotherapy, or combinations of these, unrecognized predisposition or chance may also play a role.

Synchronous Wilms Tumor and Fibrolamellar Hepatocellular Carcinoma: Report of a Case

2000 ◽  
Vol 3 (5) ◽  
pp. 492-496 ◽  
Author(s):  
Anirban Maitra ◽  
Dharamdas M. Ramnani ◽  
Linda R. Margraf ◽  
Adi F. Gazdar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Solid Tumors ◽  
Molecular Analysis ◽  
Wilms Tumor ◽  
P53 Mutation ◽  
Malignant Neoplasms ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
First Report ◽  
Second Malignant Neoplasms

Fibrolamellar hepatocellular carcinoma (FHCC) is a unique histologic variant of HCC that occurs in a younger subset of patients than classical HCC, and is associated with a better prognosis. Wilms tumor (WT) is a malignant embryonal neoplasm of the kidney and is one of the most common solid tumors of childhood, occurring at an estimated frequency of 1 in 8000 to 10,000 births. Although second malignant neoplasms (SMNs) following therapy for WTs have been reported in the liver, the coexistence of HCC and WT is extremely rare. We present the first report of a synchronous ana-plastic WT and FHCC in a previously healthy 4-year-old girl. Despite the presence of focal immunohistochemical positivity for p53 in the WT, molecular analysis failed to reveal a germline or somatic p53 mutation, and was inconclusive in establishing a clonal relation between the two tumors.

scholarly journals Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma

Cancer ◽  
2014 ◽  
Vol 120 (24) ◽  
pp. 3987-3993 ◽  
Author(s):  
Jean S. Lee ◽  
Steven G. DuBois ◽  
W. John Boscardin ◽  
Rosanna L. Wustrack ◽  
Robert E. Goldsby
Keyword(s):  
Young Adults ◽  
Adolescents And Young Adults ◽  
Malignant Neoplasms

Second Malignant Neoplasms in Surivors of Wilms' Tumor: A Report From the National Wilms' Tumor Study

1988 ◽  
Vol 80 (8) ◽  
pp. 592-595 ◽  
Author(s):  
N. E. Breslow ◽  
P. A. Norkool ◽  
A. Olshan ◽  
A. Evans ◽  
G. J. D'Angio
Keyword(s):  
Wilms Tumor ◽  
Malignant Neoplasms ◽  
Tumor Study ◽  
Second Malignant Neoplasms

Acute lymphoblastic leukemia occurring as a second malignant neoplasm in childhood: report of three cases and review of the literature.

1992 ◽  
Vol 10 (1) ◽  
pp. 156-163 ◽  
Author(s):  
S P Hunger ◽  
J Sklar ◽  
M P Link
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Wilms Tumor ◽  
Lymphoblastic Leukemia ◽  
Malignant Neoplasm ◽  
Malignant Neoplasms ◽  
Long Term Effects ◽  
Second Malignant Neoplasm ◽  
Second Malignant Neoplasms ◽  
Adults And Children ◽  
Secondary All

PURPOSE The long-term effects of childhood cancer and its therapy are a problem of increasing concern. One of the most important of these late effects is the development of second malignant neoplasms (SMNs), which occur in approximately 8% of children within 20 years of diagnosis of a malignancy. These secondary cancers may result (individually or in combination) from increased genetic susceptibility, the mutagenic effects of chemotherapy and/or radiation therapy, or chance. Whereas the development of acute nonlymphocytic leukemia (ANLL) as an SMN is a well-recognized phenomenon, acute lymphoblastic leukemia (ALL) has been infrequently described as an SMN in either adults or children. PATIENTS AND METHODS We report three patients treated at our institution in whom ALL developed as an SMN after treatment for neuroblastoma, Wilms' tumor, and Hodgkin's disease. These cases prompted us to review the published literature for cases of secondary ALL in childhood. Patients whose initial malignancy was diagnosed at age less than 16 years were classified as pediatric patients. SMNs were defined as cancers of clearly distinct histologic type occurring 6 or more months after diagnosis of the first malignant neoplasm. RESULTS Including the three index cases, a total of 18 children with secondary ALL are reviewed, and the clinical features are discussed and compared with those of secondary ANLL. CONCLUSIONS This review summarizes the published case histories of secondary ALL. The data suggest that ALL represents approximately 5% to 10% of the cases of acute leukemia that arise as SMNs in both adults and children.

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