scholarly journals Increased risk of second malignant neoplasms in adolescents and young adults with cancer

Cancer ◽  
2015 ◽  
Vol 122 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Jean S. Lee ◽  
Steven G. DuBois ◽  
Peter F. Coccia ◽  
Archie Bleyer ◽  
Rebecca L. Olin ◽  
...  
Keyword(s):  
Young Adults ◽  
Adolescents And Young Adults ◽  
Malignant Neoplasms ◽  
Increased Risk ◽  
Second Malignant Neoplasms

scholarly journals Second malignant neoplasms among children, adolescents and young adults with Wilms tumor

2015 ◽  
Vol 62 (7) ◽  
pp. 1259-1264 ◽  
Author(s):  
Jean S. Lee ◽  
Benjamin Padilla ◽  
Steven G. DuBois ◽  
Aris Oates ◽  
John Boscardin ◽  
...  
Keyword(s):  
Young Adults ◽  
Wilms Tumor ◽  
Adolescents And Young Adults ◽  
Malignant Neoplasms ◽  
Second Malignant Neoplasms

Epidemiological Trends in Attempted Suicide in Adolescents and Young Adults Between 1996 and 2004

Crisis ◽  
2009 ◽  
Vol 30 (3) ◽  
pp. 115-119 ◽  
Author(s):  
Stephanie De Munck ◽  
Gwendolyn Portzky ◽  
Kees Van Heeringen
Keyword(s):  
Young Adults ◽  
Attempted Suicide ◽  
Suicide Attempts ◽  
Epidemiological Studies ◽  
Adolescents And Young Adults ◽  
University Hospital ◽  
International Studies ◽  
Suicide Attempters ◽  
Increased Risk ◽  
Epidemiological Trends

Background: Notwithstanding the epidemiological studies indicating an increased risk of attempted suicide among adolescents and young adults, there is a scarcity of international studies that examine long-term epidemiological trends in rates and characteristics of this vulnerable group. Aims: This article describes the results of a 9-year monitoring study of suicide attempts in adolescents and young adults referred to the Accident and Emergency Department of the Gent University Hospital (Belgium). Methods: Between January 1996 and December 2004, trends, sociodemographic, and methodrelated characteristics of suicide attempts were assessed by a psychiatrist on data sheets. Results: Attempted suicide rates declined from 1996 to 2001 and then rose until 2004, but did not exceed previous rates. During the 9 years of monitoring, there was a preponderance of female suicide attempters, except for 1997. Rates of attempts and of fatal suicide were negatively correlated. Significantly more males than females deliberately injured themselves. Younger attempters, especially females, significantly more often poisoned themselves with analgesics. In nearly one in five attempts, alcohol was used in combination with other methods, and alcohol intake was more commonly observed in older suicide attempters. Nearly half of the adolescents were identified as repeaters. Conclusions: The results of this study warrant further monitoring of trends and characteristics of young suicide attempters.

An Increased Risk of Second Malignant Neoplasms After Rhabdomyosarcoma: Population-Based Evidence for a Cancer Predisposition Syndrome?

2015 ◽  
Vol 63 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Natasha M. Archer ◽  
Renata Parada Amorim ◽  
Rafaela Naves ◽  
Simone Hettmer ◽  
Lisa R. Diller ◽  
...  
Keyword(s):  
Population Based ◽  
Cancer Predisposition ◽  
Malignant Neoplasms ◽  
Cancer Predisposition Syndrome ◽  
Increased Risk ◽  
Second Malignant Neoplasms

scholarly journals Prevalence and heritability of body dysmorphic symptoms in adolescents and young adults: a population-based nationwide twin study

2018 ◽  
Vol 48 (16) ◽  
pp. 2740-2747 ◽  
Author(s):  
Jesper Enander ◽  
Volen Z. Ivanov ◽  
David Mataix-Cols ◽  
Ralf Kuja-Halkola ◽  
Brjánn Ljótsson ◽  
...  
Keyword(s):  
Young Adults ◽  
Body Dysmorphic Disorder ◽  
Age Of Onset ◽  
Model Fitting ◽  
Population Based ◽  
Adolescents And Young Adults ◽  
Shared Environment ◽  
Increased Risk ◽  
Clinically Significant ◽  
Alcohol Related Problems

AbstractBackgroundBody dysmorphic disorder (BDD) usually begins during adolescence but little is known about the prevalence, etiology, and patterns of comorbidity in this age group. We investigated the prevalence of BDD symptoms in adolescents and young adults. We also report on the relative importance of genetic and environmental influences on BDD symptoms, and the risk for co-existing psychopathology.MethodsPrevalence of BDD symptoms was determined by a validated cut-off on the Dysmorphic Concerns Questionnaire (DCQ) in three population-based twin cohorts at ages 15 (n = 6968), 18 (n = 3738), and 20–28 (n = 4671). Heritability analysis was performed using univariate model-fitting for the DCQ. The risk for co-existing psychopathology was expressed as odds ratios (OR).ResultsThe prevalence of clinically significant BDD symptoms was estimated to be between 1 and 2% in the different cohorts, with a significantly higher prevalence in females (1.3–3.3%) than in males (0.2–0.6%). The heritability of body dysmorphic concerns was estimated to be 49% (95% CI 38–54%) at age 15, 39% (95% CI 30–46) at age 18, and 37% (95% CI 29–42) at ages 20–28, with the remaining variance being due to non-shared environment. ORs for co-existing neuropsychiatric and alcohol-related problems ranged from 2.3 to 13.2.ConclusionsClinically significant BDD symptoms are relatively common in adolescence and young adulthood, particularly in females. The low occurrence of BDD symptoms in adolescent boys may indicate sex differences in age of onset and/or etiological mechanisms. BDD symptoms are moderately heritable in young people and associated with an increased risk for co-existing neuropsychiatric and alcohol-related problems.

Second malignant neoplasms (SMN) among 18,627 testicular cancer survivors (TCS) after chemotherapy (CHEM) or surgery (SURG).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1536-1536
Author(s):  
Chunkit Fung ◽  
Sophie D. Fossa ◽  
Michael T Milano ◽  
Mandi Yu ◽  
Melissa Worman ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Population Based ◽  
Baseline Risk ◽  
Malignant Neoplasms ◽  
Solid Cancer ◽  
Site Specific ◽  
Increased Risk ◽  
Absolute Excess Risk ◽  
Second Malignant Neoplasms ◽  
Testicular Cancer Survivors

1536 Background: Increased risks of SMN after radiotherapy (RT) for testicular cancer (TC) are well established. Few population-based studies, however, have focused on SMN risk among a contemporary group of TCS managed initially with non-RT approaches, including CHEM. Methods: Standardized incidence ratios (SIR) of SMN stratified by site and time since TC diagnosis were calculated for 18,627 TCS reported to the SEER program (1980-2008) who initially had CHEM (n=8,058) or SURG (n=10,569) alone without RT, with each cohort accruing 65,398 and 92,681 person-years (PY) of follow-up respectively. Results: After CHEM, significantly increased risks of solid cancers (n=154; SIR 1.3; 95% CI 1.1-1.5; absolute excess risk (AER) 5.4 per 10,000 PY) and leukemias (n=18, SIR 3.9; 95% CI 2.3-6.1; AER 2.0) were observed. Solid cancer risk remained elevated for > 20 yrs, whereas excess leukemias were concentrated within 10 years after diagnosis. SIRs for solid cancers during the <1, 1-4, 5-9, 10-14, 15-19, and 20+ yr periods were 2.0 (95% CI 1.03-3.5), 1.4 (95% CI 0.97-2.0), 0.8 (95% CI 0.5-1.2), 1.3 (95% CI 0.9-1.8), 1.6 (95% CI 1.05-2.2), and 1.5 (95% CI 0.95-2.2) respectively (P-trend 0.5) whereas SIRs for leukemia were 3.2, 9.9 (P<0.05), 2.6, and 2.3 respectively, with no cases reported in the latter 2 intervals. Median latencies to the development of solid cancers and leukemia were 12.5 yr (0.1-28) and 2.5 yr (0.1-14) respectively. Increased site-specific risks were apparent for cancers of liver (SIR 1.9; 95% CI 0.6-4.4); pancreas (SIR 2.1; 95% CI 0.8-4.6); soft tissue (SIR 4.9; 95% CI 2.1-9.7); bladder (SIR 1.9; 95% CI 1.02-3.3); kidney (SIR 2.6; 95% CI 1.4-4.3); brain/CNS (SIR 1.8; 95% CI 0.7-3.7), and thyroid (SIR 3.9; 95% CI 2.1-6.6). Secondary leukemias included 16 non-lymphocytic and 2 lymphocytic leukemias. In contrast, among TCS managed initially with SURG alone, no excess solid cancers were observed (n=198; SIR 1.0; 95% CI 0.8-1.1), albeit an increased risk of leukemia (n=15; SIR 1.9; 95% CI 1.1-3.2, AER 0.8) was seen. Conclusions: Future analytic studies should further evaluate the site-specific risks of SMN after modern CHEM for TC and the baseline risk among patients managed with non-cytotoxic approaches.

scholarly journals Trends and gender differences in age at sex debut among adolescents and young adults in urban Cape Area, South Africa

1970 ◽  
Vol 19 (4) ◽  
pp. 2964-2972
Author(s):  
Evans Muchiri ◽  
Clifford Odimegwu
Keyword(s):  
Risk Factors ◽  
South Africa ◽  
Gender Differences ◽  
Young Adults ◽  
Sexual Debut ◽  
Adolescents And Young Adults ◽  
Community Factors ◽  
Contextual Risk ◽  
Increased Risk ◽  
And Gender

Background: Adolescents and young adults in South Africa are at increased risk of experiencing negative outcomes from early sex initiation due to the context they develop in. This study aimed at investigating trends and gender differences in early age at sexual debut.Methods: Data from the Cape Area Panel Study (CAPS) of young adults’ conducted between 2002 and 2009 in urban Cape Town were used. Correlates of early sex using ecological risk factors were analysed. Results: Overall mean age at sexual debut at follow-up was 17.5 years (standard deviation (SD) =2.5), with males at 16.8 years (SD=2.5) and 18.1 years (SD=2.4) for females. Males consistently reported an earlier age at sex debut across the five waves of the survey. Significant risk factors for early sex appeared at all levels of the ecology to include individual, household, and community factors. Conclusions: Integrated interventions for delaying early sex debut should consider factors within the ecology of the young adults’ development context.Keywords: Sex debut, adolescents and young adults, contextual risk factors, cumulative risk.

Cotard's syndrome in adolescents and young adults is associated with an increased risk of bipolar disorder

2007 ◽  
Vol 9 (6) ◽  
pp. 665-668 ◽  
Author(s):  
Angèle Consoli ◽  
Charlotte Soultanian ◽  
Marie-Laure Tanguy ◽  
Claudine Laurent ◽  
Didier Perisse ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young Adults ◽  
Adolescents And Young Adults ◽  
Increased Risk
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