scholarly journals Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT 1A receptor in the mouse striatum and prefrontal cortex

2021 ◽  
Vol 41 (1) ◽  
pp. 91-101
Author(s):  
Yoko Hagino ◽  
Frank Scott Hall ◽  
George R. Uhl ◽  
Ichiro Sora ◽  
Kazutaka Ikeda
Keyword(s):  
Prefrontal Cortex ◽  
Serotonin Transporter ◽  
Mouse Striatum

scholarly journals The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration

2020 ◽  
pp. e12896 ◽  
Author(s):  
Lucia Caffino ◽  
Francesca Mottarlini ◽  
Boyd Van Reijmersdal ◽  
Francesca Telese ◽  
Michel M.M. Verheij ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Serotonin Transporter ◽  
Self Administration ◽  
Glutamatergic Signaling ◽  
Long Access

scholarly journals Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex

2015 ◽  
Vol 132 (5) ◽  
pp. 379-388 ◽  
Author(s):  
S. J. Harrison ◽  
A. E. Tyrer ◽  
R. D. Levitan ◽  
X. Xu ◽  
S. Houle ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Serotonin Transporter ◽  
Light Therapy ◽  
Anterior Cingulate

scholarly journals Dorsomedial Prefrontal Cortex Mediates the Impact of Serotonin Transporter Linked Polymorphic Region Genotype on Anticipatory Threat Reactions

2015 ◽  
Vol 78 (8) ◽  
pp. 582-589 ◽  
Author(s):  
Floris Klumpers ◽  
Marijn C. Kroes ◽  
Ivo Heitland ◽  
Daphne Everaerd ◽  
Sophie E.A. Akkermans ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Serotonin Transporter ◽  
Polymorphic Region ◽  
Dorsomedial Prefrontal Cortex ◽  
The Impact

scholarly journals Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT1A Receptor with 5-HT3 Receptor Inhibition in Rats

2019 ◽  
Vol 20 (24) ◽  
pp. 6235 ◽  
Author(s):  
Motohiro Okada ◽  
Ruri Okubo ◽  
Kouji Fukuyama
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Serotonin Transporter ◽  
Raphe Nucleus ◽  
Clinical Effects ◽  
Partial Agonism ◽  
Lower Affinity ◽  
Receptor Inhibition ◽  
Freely Moving ◽  
Antidepressant Action

Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5-HT7R) receptors and partial agonism to serotonin 5-HT1A (5-HT1AR) receptors in humans. Vortioxetine has a lower affinity to 5-HT1AR and 5-HT7R in rats compared with humans, but several behavior studies have demonstrated its powerful antidepressant-like actions. In spite of these efforts, detailed effects of the subchronic administration of vortioxetine on serotonergic transmission remain to be clarified. This study examined the mechanisms underlying the clinical effects of vortioxetine by measuring the releases of 5-HT and GABA in the medial prefrontal cortex (mPFC) of freely moving rats compared with the selective SET inhibitor, escitalopram. Inhibition of 5-HT3R in the mPFC enhanced regional 5-HT release via GABAergic disinhibition. Activation of somatodendritic 5-HT1AR in the dorsal raphe nucleus (DRN) and presynaptic 5-HT1AR in the mPFC inhibited 5-HT release in the mPFC. Escitalopram subchronically activated mesocortical serotonergic transmission via desensitization of 5-HT1AR in the mPFC and DRN and of 5-HT3R in the mPFC; however, vortioxetine also subchronically activated mesocortical serotonergic transmission via desensitization of 5-HT1AR in the mPFC and DRN but not of 5-HT3R in the mPFC. These demonstrations, the desensitization of 5-HT1AR with the inhibition of 5-HT3R (without 5-HT3R desensitization), at least partially, contribute to the multimodal antidepressant action of vortioxetine in rats.

scholarly journals Alterations of Glutamatergic Markers in the Prefrontal Cortex of Serotonin Transporter Knockout Rats: A Developmental Timeline

2019 ◽  
Vol 39 (5) ◽  
pp. 715-720 ◽  
Author(s):  
Paola Brivio ◽  
Judith R. Homberg ◽  
Marco A. Riva ◽  
Francesca Calabrese
Keyword(s):  
Prefrontal Cortex ◽  
Serotonin Transporter
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