Initial stages of radial glia astrocytic transformation in the early postnatal anterior subventricular zone

2002 ◽  
Vol 52 (3) ◽  
pp. 251-265 ◽  
Author(s):  
José A. J. Alves ◽  
Patrick Barone ◽  
Simone Engelender ◽  
Maira M. Fróes ◽  
João R. L. Menezes
Keyword(s):  
Subventricular Zone ◽  
Radial Glia ◽  
Anterior Subventricular Zone

Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors

Development ◽  
2001 ◽  
Vol 128 (5) ◽  
pp. 689-702 ◽  
Author(s):  
C.B. Chambers ◽  
Y. Peng ◽  
H. Nguyen ◽  
N. Gaiano ◽  
G. Fishell ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Cell Fate ◽  
Subventricular Zone ◽  
Cellular Proliferation ◽  
Precursor Cells ◽  
Temporal Cues ◽  
Short And Long Term ◽  
Cortical Regions ◽  
Anterior Subventricular Zone

The olfactory bulb, neocortex and archicortex arise from a common pool of progenitors in the dorsal telencephalon. We studied the consequences of supplying excess Notch1 signal in vivo on the cellular and regional destinies of telencephalic precursors using bicistronic replication defective retroviruses. After ventricular injections mid-neurogenesis (E14.5), activated Notch1 retrovirus markedly inhibited the generation of neurons from telencephalic precursors, delayed the emergence of cells from the subventricular zone (SVZ), and produced an augmentation of glial progeny in the neo- and archicortex. However, activated Notch1 had a distinct effect on the progenitors of the olfactory bulb, markedly reducing the numbers of cells of any type that migrated there. To elucidate the mechanism of the cell fate changes elicited by Notch1 signals in the cortical regions, short- and long-term cultures of E14.5 telencephalic progenitors were examined. These studies reveal that activated Notch1 elicits a cessation of proliferation that coincides with an inhibition of the generation of neurons. Later, during gliogenesis, activated Notch1 triggers a rapid cellular proliferation with a significant increase in the generation of cells expressing GFAP. To examine the generation of cells destined for the olfactory bulb, we used stereotaxic injections into the early postnatal anterior subventricular zone (SVZa). We observed that precursors of the olfactory bulb responded to Notch signals by remaining quiescent and failing to give rise to differentiated progeny of any type, unlike cortical precursor cells, which generated glia instead of neurons. These data show that forebrain precursors vary in their response to Notch signals according to spatial and temporal cues, and that Notch signals influence the composition of forebrain regions by modulating the rate of proliferation of neural precursor cells.

Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset

Science ◽  
2020 ◽  
Vol 369 (6503) ◽  
pp. 546-550 ◽  
Author(s):  
Michael Heide ◽  
Christiane Haffner ◽  
Ayako Murayama ◽  
Yoko Kurotaki ◽  
Haruka Shinohara ◽  
...  
Keyword(s):  
Subventricular Zone ◽  
Radial Glia ◽  
Common Marmoset ◽  
Primate Evolution ◽  
Specific Gene ◽  
Mammalian Evolution ◽  
Human Promoter ◽  
Neocortical Development ◽  
The Common ◽  
Human Specific

The neocortex has expanded during mammalian evolution. Overexpression studies in developing mouse and ferret neocortex have implicated the human-specific gene ARHGAP11B in neocortical expansion, but the relevance for primate evolution has been unclear. Here, we provide functional evidence that ARHGAP11B causes expansion of the primate neocortex. ARHGAP11B expressed in fetal neocortex of the common marmoset under control of the gene’s own (human) promoter increased the numbers of basal radial glia progenitors in the marmoset outer subventricular zone, increased the numbers of upper-layer neurons, enlarged the neocortex, and induced its folding. Thus, the human-specific ARHGAP11B drives changes in development in the nonhuman primate marmoset that reflect the changes in evolution that characterize human neocortical development.

Dye coupling and connexin expression by cortical radial glia in the early postnatal subventricular zone

2012 ◽  
Vol 72 (12) ◽  
pp. 1482-1497 ◽  
Author(s):  
Andressa S. Freitas ◽  
Anna L.R. Xavier ◽  
Carla M. Furtado ◽  
Cecilia Hedin-Pereira ◽  
Maira M. Fróes ◽  
...  
Keyword(s):  
Subventricular Zone ◽  
Radial Glia ◽  
Dye Coupling ◽  
Connexin Expression

Neurogenic radial glia in the outer subventricular zone of human neocortex

Nature ◽  
2010 ◽  
Vol 464 (7288) ◽  
pp. 554-561 ◽  
Author(s):  
David V. Hansen ◽  
Jan H. Lui ◽  
Philip R. L. Parker ◽  
Arnold R. Kriegstein
Keyword(s):  
Subventricular Zone ◽  
Radial Glia ◽  
Human Neocortex

scholarly journals Subacute Transplantation of Native and Genetically Engineered Neural Progenitors Seeded on Microsphere Scaffolds Promote Repair and Functional Recovery After Traumatic Brain Injury

ASN NEURO ◽  
2019 ◽  
Vol 11 ◽  
pp. 175909141983018 ◽  
Author(s):  
Nolan B. Skop ◽  
Sweta Singh ◽  
Henri Antikainen ◽  
Chaitali Saqcena ◽  
Frances Calderon ◽  
...  
Keyword(s):  
Stem Cell ◽  
Functional Recovery ◽  
Subventricular Zone ◽  
Brain Injuries ◽  
Radial Glia ◽  
Therapeutic Potential ◽  
Ventricular Zone ◽  
Neural Progenitors ◽  
Functional Improvement

There is intense interest and effort toward regenerating the brain after severe injury. Stem cell transplantation after insult to the central nervous system has been regarded as the most promising approach for repair; however, engrafting cells alone might not be sufficient for effective regeneration. In this study, we have compared neural progenitors (NPs) from the fetal ventricular zone (VZ), the postnatal subventricular zone, and an immortalized radial glia (RG) cell line engineered to conditionally secrete the trophic factor insulin-like growth factor 1 (IGF-1). Upon differentiation in vitro, the VZ cells were able to generate a greater number of neurons than subventricular zone cells. Furthermore, differentiated VZ cells generated pyramidal neurons . In vitro, doxycycline-driven secretion of IGF-1 strongly promoted neuronal differentiation of cells with hippocampal, interneuron and cortical specificity. Accordingly, VZ and engineered RG-IGF-1-hemagglutinin (HA) cells were selected for subsequent in vivo experiments. To increase cell survival, we delivered the NPs attached to a multifunctional chitosan-based scaffold. The microspheres containing adherent NPs were injected subacutely into the lesion cavity of adult rat brains that had sustained controlled cortical impact injury. At 2 weeks posttransplantation, the exogenously introduced cells showed a reduction in stem cell or progenitor markers and acquired mature neuronal and glial markers. In beam walking tests assessing sensorimotor recovery, transplanted RG cells secreting IGF-1 contributed significantly to functional improvement while native VZ or RG cells did not promote significant recovery. Altogether, these results support the therapeutic potential of chitosan-based multifunctional microsphere scaffolds seeded with genetically modified NPs expressing IGF-1 to promote repair and functional recovery after traumatic brain injuries.

scholarly journals Diffusion MRI changes in the anterior subventricular zone following chemoradiation in glioblastoma with posterior ventricular involvement

2020 ◽  
Vol 147 (3) ◽  
pp. 643-652
Author(s):  
Nicholas Cho ◽  
Chencai Wang ◽  
Catalina Raymond ◽  
Tania Kaprealian ◽  
Matthew Ji ◽  
...  
Keyword(s):  
Subventricular Zone ◽  
Diffusion Mri ◽  
Mri Changes ◽  
Anterior Subventricular Zone

Gap Junction-Mediated Coupling in the Postnatal Anterior Subventricular Zone

2000 ◽  
Vol 22 (1-2) ◽  
pp. 34-43 ◽  
Author(s):  
João R.L. Menezes ◽  
Maira M. Fróes ◽  
Vivaldo Moura Neto ◽  
Roberto Lent
Keyword(s):  
Gap Junction ◽  
Subventricular Zone ◽  
Anterior Subventricular Zone

scholarly journals Radial glia give rise to adult neural stem cells in the subventricular zone

2004 ◽  
Vol 101 (50) ◽  
pp. 17528-17532 ◽  
Author(s):  
F. T. Merkle ◽  
A. D. Tramontin ◽  
J. M. Garcia-Verdugo ◽  
A. Alvarez-Buylla
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Subventricular Zone ◽  
Radial Glia ◽  
Adult Neural Stem Cells
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