In vivo diffusion tensor magnetic resonance imaging and fiber tracking of the mouse brain

2010 ◽  
Vol 23 (7) ◽  
pp. 884-896 ◽  
Author(s):  
Laura-Adela Harsan ◽  
Dominik Paul ◽  
Susanne Schnell ◽  
Bjorn W. Kreher ◽  
Jürgen Hennig ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mouse Brain ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Resonance Imaging

In vivo magnetic resonance imaging of single cells in mouse brain with optical validation

2005 ◽  
Vol 55 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Chris Heyn ◽  
John A. Ronald ◽  
Lisa T. Mackenzie ◽  
Ian C. MacDonald ◽  
Ann F. Chambers ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mouse Brain ◽  
Single Cells ◽  
Resonance Imaging

Magnetic Resonance Imaging Diffusion Tensor Tractography: Evaluation of Anatomic Accuracy of Different Fiber Tracking Software Packages

2014 ◽  
Vol 81 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Guenther C. Feigl ◽  
Wolfgang Hiergeist ◽  
Claudia Fellner ◽  
Karl-Michael M. Schebesch ◽  
Christian Doenitz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Diffusion Tensor Tractography ◽  
Resonance Imaging ◽  
Software Packages

scholarly journals Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis

2021 ◽  
Author(s):  
Ruiqing Ni
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Animal Models ◽  
Amyloid Beta ◽  
High Field ◽  
Diffusion Tensor ◽  
Small Animal ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Amyloid-beta plays an important role in the pathogenesis of Alzheimer’s disease. Aberrant amyloid-beta and tau accumulation induce neuroinflammation, cerebrovascular alterations, synaptic deficits, functional deficits, and neurodegeneration, leading to cognitive impairment. Animal models recapitulating the amyloid-beta pathology such as transgenic, knock-in mouse and rat models have facilitated the understanding of disease mechanisms and development of therapeutics targeting at amyloid-beta. There is a rapid advance in high-field MR in small animals. Versatile high-field magnetic resonance imaging (MRI) sequences such as diffusion tensor imaging, arterial spin labelling, resting-state functional MRI, anatomical MRI, MR spectroscopy as well as contrast agents have been developed for the applications in animal models. These tools have enabled high-resolution in vivo structural, functional, and molecular readouts with a whole brain field-of-view. MRI have been utilized to visualize non-invasively the amyloid-beta deposits, synaptic deficits, regional brain atrophy, impairment in white matter integrity, functional connectivity, cerebrovascular and glymphatic system in animal models of amyloidosis. Many of the readouts are translational in clinical MRI in the brain of patients with Alzheimer’s disease. In this review, we summarize the recent advance of using MRI for visualizing the pathophysiology in amyloidosis animal model. We discuss the outstanding challenges in brain imaging using MRI in small animal and propose future outlook in visualizing amyloid-beta-related alterations in brain of animal models.

scholarly journals Fast Diffusion Tensor Magnetic Resonance Imaging of the Mouse Brain at Ultrahigh-Field: Aiming at Cohort Studies

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e53389 ◽  
Author(s):  
Hans-Peter Müller ◽  
Ina Vernikouskaya ◽  
Albert C. Ludolph ◽  
Jan Kassubek ◽  
Volker Rasche
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cohort Studies ◽  
Mouse Brain ◽  
Diffusion Tensor ◽  
Fast Diffusion ◽  
Resonance Imaging ◽  
Ultrahigh Field

Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging

2006 ◽  
Vol 83 (3) ◽  
pp. 392-402 ◽  
Author(s):  
Laura A. Harsan ◽  
Patrick Poulet ◽  
Blandine Guignard ◽  
Jérôme Steibel ◽  
Nathalie Parizel ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Resonance Imaging ◽  
Recovery Assessment
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