Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging

2006 ◽  
Vol 83 (3) ◽  
pp. 392-402 ◽  
Author(s):  
Laura A. Harsan ◽  
Patrick Poulet ◽  
Blandine Guignard ◽  
Jérôme Steibel ◽  
Nathalie Parizel ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Resonance Imaging ◽  
Recovery Assessment

scholarly journals Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis

2021 ◽  
Author(s):  
Ruiqing Ni
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Animal Models ◽  
Amyloid Beta ◽  
High Field ◽  
Diffusion Tensor ◽  
Small Animal ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Amyloid-beta plays an important role in the pathogenesis of Alzheimer’s disease. Aberrant amyloid-beta and tau accumulation induce neuroinflammation, cerebrovascular alterations, synaptic deficits, functional deficits, and neurodegeneration, leading to cognitive impairment. Animal models recapitulating the amyloid-beta pathology such as transgenic, knock-in mouse and rat models have facilitated the understanding of disease mechanisms and development of therapeutics targeting at amyloid-beta. There is a rapid advance in high-field MR in small animals. Versatile high-field magnetic resonance imaging (MRI) sequences such as diffusion tensor imaging, arterial spin labelling, resting-state functional MRI, anatomical MRI, MR spectroscopy as well as contrast agents have been developed for the applications in animal models. These tools have enabled high-resolution in vivo structural, functional, and molecular readouts with a whole brain field-of-view. MRI have been utilized to visualize non-invasively the amyloid-beta deposits, synaptic deficits, regional brain atrophy, impairment in white matter integrity, functional connectivity, cerebrovascular and glymphatic system in animal models of amyloidosis. Many of the readouts are translational in clinical MRI in the brain of patients with Alzheimer’s disease. In this review, we summarize the recent advance of using MRI for visualizing the pathophysiology in amyloidosis animal model. We discuss the outstanding challenges in brain imaging using MRI in small animal and propose future outlook in visualizing amyloid-beta-related alterations in brain of animal models.

P1-198: White matter damage in posterior cortical atrophy assessed in vivo using diffusion tensor magnetic resonance imaging

2012 ◽  
Vol 8 (4S_Part_5) ◽  
pp. P176-P177
Author(s):  
Shiva Keihaninejad ◽  
Hui Zhang ◽  
Tim Shakespeare ◽  
Natalie Ryan ◽  
Ian Malone ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Cortical Atrophy ◽  
Resonance Imaging ◽  
Posterior Cortical Atrophy ◽  
White Matter Damage

Three-Dimensional In Vivo Modeling of Vestibular Schwannomas and Surrounding Cranial Nerves With Diffusion Imaging Tractography

Neurosurgery ◽  
2011 ◽  
Vol 68 (4) ◽  
pp. 1077-1083 ◽  
Author(s):  
David Qixiang Chen ◽  
Jessica Quan ◽  
Abhijit Guha ◽  
Michael Tymianski ◽  
David Mikulis ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
3D Visualization ◽  
Cranial Nerves ◽  
Spatial Relationship ◽  
Vestibular Schwannomas ◽  
Gasserian Ganglion ◽  
Resonance Imaging

Abstract BACKGROUND: Preservation of cranial nerves (CNs) is of paramount concern in the treatment of vestibular schwannomas, particularly in large tumors with thinned and distorted CN fibers. However, imaging of the CN fibers surrounding vestibular schwannomas has been limited with 2-dimensional imaging alone. OBJECTIVE: To assess whether tractography of the CN combined with anatomic magnetic resonance imaging of the tumor can provide superior 3-dimensional (3D) visualization of tumor/CN complexes. METHODS: Magnetic resonance imaging at 3 T, including diffusion tensor imaging and anatomic images, were analyzed in 3 subjects with vestibular schwannomas using 3D Slicer software. The diffusion tensor images were used to track the courses of trigeminal, abducens, facial, and vestibulocochlear nerves. The anatomic images were used to model the 3D volume reconstruction of the tumor. The 2 sets of images were then superimposed through the use of linear registration. RESULTS: Combined 3D tumor modeling and CN tractography can effectively and consistently reconstruct the 3D spatial relationship of CN/tumor complexes and allows superior visualization compared with 2-dimensional imaging. Lateral and superior distortion of the trigeminal nerve was observed in all cases. The position of the facial nerve was primarily anteriorly and inferiorly. The gasserian ganglion and early postganglionic branches could also be visualized. CONCLUSION: Tractography and anatomic imaging were successfully combined to demonstrate the precise location of surrounding CN fibers. This technique can be useful in both neuronavigation and radiosurgical planning. Because knowledge of the course of these fibers is of important clinical interest, implementation of this technique may help decrease injury to CNs during treatment of these lesions.

scholarly journals Microstructural Impact of Ischemia and Bone Marrow–Derived Cell Therapy Revealed With Diffusion Tensor Magnetic Resonance Imaging Tractography of the Heart In Vivo

Circulation ◽  
2014 ◽  
Vol 129 (17) ◽  
pp. 1731-1741 ◽  
Author(s):  
David E. Sosnovik ◽  
Choukri Mekkaoui ◽  
Shuning Huang ◽  
Howard H. Chen ◽  
Guangping Dai ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Magnetic Resonance ◽  
Cell Therapy ◽  
Diffusion Tensor ◽  
Resonance Imaging
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