scholarly journals Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X-linked myotubular myopathy

2014 ◽  
Vol 50 (4) ◽  
pp. 607-609 ◽  
Author(s):  
Aarti Sarwal ◽  
Michael S. Cartwright ◽  
Francis O. Walker ◽  
Erin Mitchell ◽  
Anna Buj-Bello ◽  
...  
Keyword(s):  
Canine Model ◽  
Myotubular Myopathy ◽  
Ultrasound Assessment ◽  
Preliminary Study

scholarly journals Exosome TDP-43 profile in canine model of ALS: A preliminary study in developing surrogate biomarker

2021 ◽  
Author(s):  
Penelope Pfeiffer ◽  
Joan R Coates ◽  
Andrew Kennedy ◽  
Kyleigh Getchell ◽  
Edina Kosa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Disease Model ◽  
Canine Model ◽  
Biological Processes ◽  
Animal Disease ◽  
Animal Disease Model ◽  
Preliminary Study ◽  
Degenerative Myelopathy

Blood-based biomarkers are much-needed diagnostic and prognostic tools for ALS. Canine degenerative myelopathy (DM) is recognized animal disease model to study the biology of human ALS. Serum derived exosomes are potential carrier that transport intercellular hormone-like messengers, together with their stability as carrier of proteins and RNA, make them ideal as biomarkers for a variety of diseases and biological processes. We study exosomal TDP-43 pattern as a surrogate biomarker that reflects biochemical changes in central nervous system. We isolated exosomes from canine serum using commercial exosome isolation reagents. TDP-43 and SOD1 profile in spinal cord homogenate lysate and that of serum-derived exosomes were found elevated in dogs with DM. We conclude levels of spinal cord TDP-43 and serum-derived exomes were similar in TDP-43 profiling, which warrant further investigation of disease sensitivity and specificity for establishing as a blood-based biomarker in canine DM.

scholarly journals Effects of a New Allograft Processing Procedure on Graft Healing in a Canine Model: A Preliminary Study

2008 ◽  
Vol 467 (1) ◽  
pp. 273-280 ◽  
Author(s):  
Kathleen S. Beebe ◽  
Joseph Benevenia ◽  
Benjamin E. Tuy ◽  
C. Alex DePaula ◽  
Robert D. Harten ◽  
...  
Keyword(s):  
Canine Model ◽  
Graft Healing ◽  
Processing Procedure ◽  
Preliminary Study

Vocal fold medialization using autologous cartilage in a canine model: A preliminary study

1995 ◽  
Vol 105 (10) ◽  
pp. 1049-1052 ◽  
Author(s):  
Marc E. Guay ◽  
Frank R. Miller ◽  
Thomas W. Bauer ◽  
Harvey M. Tucker
Keyword(s):  
Vocal Fold ◽  
Canine Model ◽  
Preliminary Study
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