scholarly journals Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage

2006 ◽  
Vol 14 (9) ◽  
pp. 882-888 ◽  
Author(s):  
C. Muehleman ◽  
J. Li ◽  
Z. Zhong
Keyword(s):  
Cartilage Damage ◽  
Canine Model ◽  
Radiographic Imaging ◽  
Preliminary Study

scholarly journals Exosome TDP-43 profile in canine model of ALS: A preliminary study in developing surrogate biomarker

2021 ◽  
Author(s):  
Penelope Pfeiffer ◽  
Joan R Coates ◽  
Andrew Kennedy ◽  
Kyleigh Getchell ◽  
Edina Kosa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Disease Model ◽  
Canine Model ◽  
Biological Processes ◽  
Animal Disease ◽  
Animal Disease Model ◽  
Preliminary Study ◽  
Degenerative Myelopathy

Blood-based biomarkers are much-needed diagnostic and prognostic tools for ALS. Canine degenerative myelopathy (DM) is recognized animal disease model to study the biology of human ALS. Serum derived exosomes are potential carrier that transport intercellular hormone-like messengers, together with their stability as carrier of proteins and RNA, make them ideal as biomarkers for a variety of diseases and biological processes. We study exosomal TDP-43 pattern as a surrogate biomarker that reflects biochemical changes in central nervous system. We isolated exosomes from canine serum using commercial exosome isolation reagents. TDP-43 and SOD1 profile in spinal cord homogenate lysate and that of serum-derived exosomes were found elevated in dogs with DM. We conclude levels of spinal cord TDP-43 and serum-derived exomes were similar in TDP-43 profiling, which warrant further investigation of disease sensitivity and specificity for establishing as a blood-based biomarker in canine DM.

scholarly journals Effects of a New Allograft Processing Procedure on Graft Healing in a Canine Model: A Preliminary Study

2008 ◽  
Vol 467 (1) ◽  
pp. 273-280 ◽  
Author(s):  
Kathleen S. Beebe ◽  
Joseph Benevenia ◽  
Benjamin E. Tuy ◽  
C. Alex DePaula ◽  
Robert D. Harten ◽  
...  
Keyword(s):  
Canine Model ◽  
Graft Healing ◽  
Processing Procedure ◽  
Preliminary Study

Vocal fold medialization using autologous cartilage in a canine model: A preliminary study

1995 ◽  
Vol 105 (10) ◽  
pp. 1049-1052 ◽  
Author(s):  
Marc E. Guay ◽  
Frank R. Miller ◽  
Thomas W. Bauer ◽  
Harvey M. Tucker
Keyword(s):  
Vocal Fold ◽  
Canine Model ◽  
Preliminary Study

scholarly journals Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X-linked myotubular myopathy

2014 ◽  
Vol 50 (4) ◽  
pp. 607-609 ◽  
Author(s):  
Aarti Sarwal ◽  
Michael S. Cartwright ◽  
Francis O. Walker ◽  
Erin Mitchell ◽  
Anna Buj-Bello ◽  
...  
Keyword(s):  
Canine Model ◽  
Myotubular Myopathy ◽  
Ultrasound Assessment ◽  
Preliminary Study

A preliminary study of particle velocity during phonation in an in vivo canine model

1989 ◽  
Vol 3 (4) ◽  
pp. 306-313 ◽  
Author(s):  
Gerald S. Berke ◽  
Dennis M. Moore ◽  
Peter A. Monkewitz ◽  
David G. Hanson ◽  
Bruce R. Gerratt
Keyword(s):  
Particle Velocity ◽  
Canine Model ◽  
Preliminary Study

Injection and adhesion palatoplasty: a preliminary study in a canine model

2013 ◽  
Vol 183 (2) ◽  
pp. 654-662 ◽  
Author(s):  
Concepción Martínez-Álvarez ◽  
Beatriz González-Meli ◽  
Beatriz Berenguer-Froehner ◽  
Irene Paradas-Lara ◽  
Yamila López-Gordillo ◽  
...  
Keyword(s):  
Canine Model ◽  
Preliminary Study

scholarly journals Validitas dan Reliabilitas Pengukuran Posisi Horizontal Menton dalam Penilaian Kesimetrisan Mandibulofasial (Kajian Sefalometri Postero-Anterior)

2018 ◽  
Vol 1 (1) ◽  
pp. 156-162
Author(s):  
Trelia Boel ◽  
Maria Purbiati ◽  
Ervina Sofyanti ◽  
Erliera Erliera
Keyword(s):  
Gold Standard ◽  
Group Symmetry ◽  
Radiographic Imaging ◽  
Validity And Reliability ◽  
Imaging Results ◽  
Anatomical Point ◽  
Measurement Results ◽  
Preliminary Study ◽  
Influence Measurement ◽  
Cephalometric Measurements

Latar belakang : Pengukuran sefalometri melibatkan penentuan titik-titik anatomis secara objektif namun juga dapat melibatkan subjektifitas pengukur dengan faktor-faktor yang dapat mempengaruhi hasil pengukuran. Dalam hal ini dibutuhkan pengujian untuk mendapatkan validitas dan reliabilitas pengukuran yang baik sehingga analisis dari hasil pengukuran dinilai akurat dan layak. Perkembangan radiografi digital yang didukung dengan perangkat lunak memudahkan operator dalam interpretasi hasil pencitraan radiografi secara kuantitatif dan kualitatif. Metode : Titik Menton (Me) merupakan titik anatomis yang sering dipakai sebagai acuan bagi penentuan kesimetrisan wajah secara horizontal pada sefalogram Postero-Anterior. Untuk membuktikan validitas pengukuran, dilakukan uji kesesuaian pada kelompok asimetri, kelompok simetri dan kelompok gabungan atas pengukuran posisi menton terhadap MSR (Mid Sagital Reference). Penelitian ini menggunakan 8 sampel simetris dan 8 sampel asimetris yang diukur oleh peneliti utama dan dibandingkan dengan peneliti baku emas (uji inter-observer). Dilakukan pula uji intra-observer dimana peneliti utama melakukan pengukuran sebanyak dua kali untuk mendapatkan bukti reliabilitas pengukuran. Hasil : Uji kesesuaian Bland Altman menunjukan bahwa hasil pengukuran menunjukkan validitas dan reliabilitas yang baik (p>0,05) untuk semua pengukuran baik inter-observer dan intra-observer Kesimpulan : Hasil pengukuran dapat digunakan sebagai studi awal untuk penelitian lanjutan dengan menentukan reliabilitas titik-titik anatomis yang dibutuhkan dalam analisis kasus asimetri mandibulofasial. Cephalometric measurements objectively determine anatomical points but it can also involve measuring subjectivity with factors that can influence measurement results. In this case a test is needed to obtain good validity and reliability of measurements so that the analysis of the measurement results is considered accurate and feasible. The development of digital radiography supported by software makes it easier for operators to interpret quantitative and qualitative radiographic imaging results. Menton Point (Me) is an anatomical point that is often used as a reference for horizontal facial symmetry in the posteroanteriorcephalogram. To prove the validity of the measurement, a suitability test was conducted in asymmetry group, symmetry group, and combined group to determine the position of the menton to MSR (Mid Sagital Reference). This study used 8 symmetrical samples and 8 asymmetrical samples measured by the main researchers and compared with the gold standard researchers (inter-observer test). An intra-observer test was also conducted where the main researcher made measurements twice to obtain the reliability of the measurement. The Bland Altman suitability test was used and the measurement results showed both measurements inter-observer and intra-observer demontrated good validity and reliability (p> 0.05) The measurement results could be used as a preliminary study for further research by determining point reliability anatomical points needed in the analysis of mandibulofacial asymmetry.

scholarly journals Meniscus Induced Cartilaginous Damage and Non-linear Gross Anatomical Progression of Early-stage Osteoarthritis in a Canine Model

2016 ◽  
Vol 10 (1) ◽  
pp. 690-705 ◽  
Author(s):  
David Kahn ◽  
Daniel Mittelstaedt ◽  
John Matyas ◽  
Xiangui Qu ◽  
Ji Hyun Lee ◽  
...  
Keyword(s):  
Mixed Model ◽  
Early Stage ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Canine Model ◽  
Posterior Aspect ◽  
Additional Information ◽  
Signed Rank ◽  
Anterior Cruciate ◽  
Meniscal Damage

Background: The predictable outcome of the anterior cruciate ligament transection (ACLT) canine model, and the similarity to naturally occurring osteoarthritis (OA) in humans, provide a translatable method for studying OA. Still, evidence of direct meniscus-induced cartilaginous damage has not been identified, and gross-anatomical blinded scoring of early-stage OA has not been performed. Objective: A gross anatomical observation and statistical analysis of OA progression to determine meniscus induced cartilaginous damage, to measure the macroscopic progression of OA, and to address matters involving arthroscopic and surgical procedures of the knee. Method: Unblinded assessment and blinded scoring of meniscal, tibial, femoral, and patellar damage were performed for control and at four time points following unilateral ACLT: 3-week (N=4), 8-week (N=4), 12-week (N=5), and 25-week (N=4). Mixed-model statistics illustrates damage (score) progression; Wilcoxon rank-sum tests compared time-point scores; and Wilcoxon signed-rank tests compared ACLT and contralateral scores, and meniscus and tibia scores. Result: Damage was manifest first on the posterior aspect of the medial meniscus and subsequently on the tibia and femur, implying meniscal damage can precede, coincide with, and aggravate cartilage damage. Damage extent varied chronologically and was dependent upon the joint component. Meniscal damage was evident at 3 weeks and progressed through 25-weeks. Meniscal loose bodies corresponded to tibial cartilage damage location and extent through 12 weeks, followed by cartilage repair activity after complete meniscal degeneration. Conclusion: This study provides additional information for understanding OA progression, identifying OA biomarkers, and arthroscopic and meniscectomy procedures.

scholarly journals Exosome TDP-43 Profile in Canine Model of ALS: A Preliminary Study in Developing Surrogate Biomarker

2021 ◽  
Author(s):  
Penelope Pfeiffer ◽  
Joan R. Coates ◽  
Andrew Kennedy ◽  
Kyleigh Getchell ◽  
Edina Kosa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Disease Model ◽  
Canine Model ◽  
Biological Processes ◽  
Animal Disease ◽  
Animal Disease Model ◽  
Preliminary Study ◽  
Degenerative Myelopathy

Blood-based biomarkers are much-needed diagnostic and prognostic tools for ALS. Canine degenerative myelopathy (DM) is recognized animal disease model to study the biology of human ALS. Serum derived exosomes are potential carrier that transport intercellular hormone-like messengers, together with their stability as carrier of proteins and RNA, make them ideal as biomarkers for a variety of diseases and biological processes. We study exosomal TDP-43 pattern as a surrogate biomarker that reflects biochemical changes in central nervous system. We isolated exosomes from canine serum using commercial exosome isolation reagents. TDP-43 and SOD1 profile in spinal cord homogenate lysate and that of serum-derived exosomes were found elevated in dogs with DM. We conclude levels of spinal cord TDP-43 and serum-derived exomes were similar in TDP-43 profiling, which warrant further investigation of disease sensitivity and specificity for establishing as a blood-based biomarker in canine DM.

Detection of Acute Gastrointestinal Bleeding by Intra-arterial Tc-99m Sulfur Colloid Scintigraphy in a Canine Model Preliminary Study

1987 ◽  
Vol 22 (1) ◽  
pp. 37-40 ◽  
Author(s):  
J. S. DENHAM ◽  
G. J. BECKER ◽  
A. R. SIDDIQUI ◽  
R. W. HOLDEN ◽  
R. G. DREESEN ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Canine Model ◽  
Sulfur Colloid ◽  
Acute Gastrointestinal Bleeding ◽  
Preliminary Study
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