scholarly journals B0-orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T

2016 ◽  
Vol 75 (6) ◽  
pp. 2455-2463 ◽  
Author(s):  
Manisha Aggarwal ◽  
Yusuke Kageyama ◽  
Xu Li ◽  
Peter C. van Zijl
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter

scholarly journals A torque balance measurement of anisotropy of the magnetic susceptibility in white matter

2014 ◽  
Vol 74 (5) ◽  
pp. 1388-1396 ◽  
Author(s):  
Peter van Gelderen ◽  
Hendrik Mandelkow ◽  
Jacco A. de Zwart ◽  
Jeff H. Duyn
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter

scholarly journals Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains

NeuroImage ◽  
2014 ◽  
Vol 102 ◽  
pp. 748-755 ◽  
Author(s):  
Wei Cao ◽  
Wei Li ◽  
Hui Han ◽  
Shonagh K. O'Leary-Moore ◽  
Kathleen K. Sulik ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Prenatal Alcohol ◽  
Susceptibility Contrast

scholarly journals Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan

2013 ◽  
Vol 35 (6) ◽  
pp. 2698-2713 ◽  
Author(s):  
Wei Li ◽  
Bing Wu ◽  
Anastasia Batrachenko ◽  
Vivian Bancroft-Wu ◽  
Rajendra A. Morey ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Human Brain ◽  
Developmental Trajectories

Implications of the magnetic susceptibility difference between grey and white matter for single-voxel proton spectroscopy at 7 T

2018 ◽  
Vol 297 ◽  
pp. 51-60 ◽  
Author(s):  
Donghyun Hong ◽  
Jack J.A. van Asten ◽  
Seyedmorteza Rohani Rankouhi ◽  
Jan-Willem Thielen ◽  
David G. Norris
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Proton Spectroscopy ◽  
Single Voxel

scholarly journals Studying magnetic susceptibility, microstructural compartmentalisation and chemical exchange in a formalin-fixed ex vivo human brain specimen

2021 ◽  
Author(s):  
Kwok-Shing Chan ◽  
Renaud Hedouin ◽  
Jeroen Mollink ◽  
Anne-Marie van Cappellen van Walsum ◽  
Jose P Marques
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Human Brain ◽  
In Vivo Imaging ◽  
Chemical Exchange ◽  
Ex Vivo ◽  
Signal Phase ◽  
Brain Specimen ◽  
Formalin Fixed

Purpose: Ex vivo imaging is a preferable method to study the biophysical mechanism of white matter orientation-dependent signal phase evolution. Yet, how formalin fixation, commonly used for tissue preservation, affects the phase measurement is not fully known. We, therefore, study the impacts of formalin fixation on magnetic susceptibility, microstructural compartmentalisation and chemical exchange measurement on human brain tissue. Methods: A formalin-fixed, post-mortem human brain specimen was scanned with multiple orientations with respect to the main magnetic field direction for robust bulk magnetic susceptibility measurement with conventional quantitative susceptibility imaging models. Homogeneous white matter tissues were subsequently excised from the whole-brain specimen and scanned in multiple rotations on an MRI scanner to measure the anisotropic magnetic susceptibility and microstructure-related contributions in the signal phase. Electron microscopy was used to validate the MRI findings. Results: The bulk isotropic magnetic susceptibility of ex vivo whole-brain imaging is comparable to in vivo imaging, with noticeable enhanced non-susceptibility contributions. The excised specimen experiment reveals that anisotropic magnetic susceptibility and compartmentalisation phase effect were considerably reduced in formalin-fixed white matter tissue. Conclusions: Despite formalin-fixed white matter tissue has comparable bulk isotropic magnetic susceptibility to those measured via in vivo imaging, its orientation-dependent components in the signal phase related to the tissue microstructure is substantially weaker, making it less favourable in white matter microstructure studies using phase imaging.

scholarly journals In vivo assessment of anisotropy of apparent magnetic susceptibility in white matter from a single orientation acquisition

NeuroImage ◽  
2021 ◽  
pp. 118442
Author(s):  
Renat Sibgatulin ◽  
Daniel Güllmar ◽  
Andreas Deistung ◽  
Stefan Ropele ◽  
Jürgen R. Reichenbach
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Single Orientation ◽  
In Vivo Assessment
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