scholarly journals Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan

2013 ◽  
Vol 35 (6) ◽  
pp. 2698-2713 ◽  
Author(s):  
Wei Li ◽  
Bing Wu ◽  
Anastasia Batrachenko ◽  
Vivian Bancroft-Wu ◽  
Rajendra A. Morey ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Human Brain ◽  
Developmental Trajectories

scholarly journals Studying magnetic susceptibility, microstructural compartmentalisation and chemical exchange in a formalin-fixed ex vivo human brain specimen

2021 ◽  
Author(s):  
Kwok-Shing Chan ◽  
Renaud Hedouin ◽  
Jeroen Mollink ◽  
Anne-Marie van Cappellen van Walsum ◽  
Jose P Marques
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Human Brain ◽  
In Vivo Imaging ◽  
Chemical Exchange ◽  
Ex Vivo ◽  
Signal Phase ◽  
Brain Specimen ◽  
Formalin Fixed

Purpose: Ex vivo imaging is a preferable method to study the biophysical mechanism of white matter orientation-dependent signal phase evolution. Yet, how formalin fixation, commonly used for tissue preservation, affects the phase measurement is not fully known. We, therefore, study the impacts of formalin fixation on magnetic susceptibility, microstructural compartmentalisation and chemical exchange measurement on human brain tissue. Methods: A formalin-fixed, post-mortem human brain specimen was scanned with multiple orientations with respect to the main magnetic field direction for robust bulk magnetic susceptibility measurement with conventional quantitative susceptibility imaging models. Homogeneous white matter tissues were subsequently excised from the whole-brain specimen and scanned in multiple rotations on an MRI scanner to measure the anisotropic magnetic susceptibility and microstructure-related contributions in the signal phase. Electron microscopy was used to validate the MRI findings. Results: The bulk isotropic magnetic susceptibility of ex vivo whole-brain imaging is comparable to in vivo imaging, with noticeable enhanced non-susceptibility contributions. The excised specimen experiment reveals that anisotropic magnetic susceptibility and compartmentalisation phase effect were considerably reduced in formalin-fixed white matter tissue. Conclusions: Despite formalin-fixed white matter tissue has comparable bulk isotropic magnetic susceptibility to those measured via in vivo imaging, its orientation-dependent components in the signal phase related to the tissue microstructure is substantially weaker, making it less favourable in white matter microstructure studies using phase imaging.

scholarly journals Mapping magnetic susceptibility anisotropies of white matter in vivo in the human brain at 7T

NeuroImage ◽  
2012 ◽  
Vol 62 (1) ◽  
pp. 314-330 ◽  
Author(s):  
Xu Li ◽  
Deepti S. Vikram ◽  
Issel Anne L. Lim ◽  
Craig K. Jones ◽  
Jonathan A.D. Farrell ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
White Matter ◽  
Human Brain

Maturation of white matter in the human brain: a review of magnetic resonance studies

2001 ◽  
Vol 54 (3) ◽  
pp. 255-266 ◽  
Author(s):  
T Paus ◽  
D.L Collins ◽  
A.C Evans ◽  
G Leonard ◽  
B Pike ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Human Brain ◽  
Magnetic Resonance Studies

scholarly journals Cortex-sparing fiber dissection: an improved method for the study of white matter anatomy in the human brain

2011 ◽  
Vol 219 (4) ◽  
pp. 531-541 ◽  
Author(s):  
Juan Martino ◽  
Philip C. De Witt Hamer ◽  
Francesco Vergani ◽  
Christian Brogna ◽  
Enrique Marco de Lucas ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Improved Method ◽  
Fiber Dissection ◽  
White Matter Anatomy

Grey and white matter GABA level differences in the human brain using two-dimensional,J-resolved spectroscopic imaging

2005 ◽  
Vol 18 (8) ◽  
pp. 570-576 ◽  
Author(s):  
J. Eric Jensen ◽  
Blaise deB. Frederick ◽  
Perry F. Renshaw
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Spectroscopic Imaging ◽  
Two Dimensional ◽  
Gaba Level

Proteomic studies on the white matter of human brain☆

2006 ◽  
Vol 833 (1) ◽  
pp. 80-90 ◽  
Author(s):  
Stefano Pozzi Mucelli ◽  
Federico Odreman ◽  
Marlen Lujardo Gonzales ◽  
Ernestina Gerardi ◽  
Giorgio Stanta ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain
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