Contribution of Sinerem® used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit

1996 ◽  
Vol 36 (3) ◽  
pp. 415-419 ◽  
Author(s):  
Isabelle Berry ◽  
Soraya Benderbous ◽  
Jean-Philippe Ranjeva ◽  
Dominique Gracia-Meavilla ◽  
Claude Manelfe ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Blood Pool ◽  
Volume Changes ◽  
Blood Pool Contrast Agent

High-resolution cerebral blood volume imaging in humans using the blood pool contrast agent ferumoxytol

2012 ◽  
Vol 70 (3) ◽  
pp. 705-710 ◽  
Author(s):  
Thomas Christen ◽  
Wendy Ni ◽  
Deqiang Qiu ◽  
Heiko Schmiedeskamp ◽  
Roland Bammer ◽  
...  
Keyword(s):  
High Resolution ◽  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Blood Pool ◽  
Blood Pool Contrast Agent ◽  
Volume Imaging

scholarly journals Basal Cerebral Blood Volume during the Poststimulation Undershoot in BOLD MRI of the Human Brain

2010 ◽  
Vol 31 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Peter Dechent ◽  
Gunther Schütze ◽  
Gunther Helms ◽  
Klaus Dietmar Merboldt ◽  
Jens Frahm
Keyword(s):  
Contrast Agent ◽  
Blood Volume ◽  
Animal Studies ◽  
Cerebral Blood Volume ◽  
Visual Stimulation ◽  
Three Dimensional ◽  
Blood Pool ◽  
Blood Oxygenation ◽  
Bold Mri ◽  
Oxygenation Level

One of the characteristics of the blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) response to functional challenges of the brain is the poststimulation undershoot, which has been suggested to originate from a delayed recovery of either cerebral blood volume (CBV) or cerebral metabolic rate of oxygen to baseline. Using bolus-tracking MRI in humans, we recently showed that relative CBV rapidly normalizes after the end of stimulation. As this observation contradicts at least part of the blood-pool contrast agent studies performed in animals, we reinvestigated the CBV contribution by dynamic T1-weighted three-dimensional MRI (8 seconds temporal resolution) and Vasovist at 3 T (12 subjects). Initially, we determined the time constants of individual BOLD responses. After injection of Vasovist, CBV-related T1-weighted signal changes revealed a signal increase during visual stimulation (1.7%±0.4%), but no change relative to baseline in the poststimulation phase (0.2%±0.3%). This finding renders the specific nature of the contrast agent unlikely to be responsible for the discrepancy between human and animal studies. With the assumption of normalized cerebral blood flow after stimulus cessation, a normalized CBV lends support to the idea that the BOLD MRI undershoot reflects a prolonged elevation of oxidative metabolism.

scholarly journals Amphiphilic DTPA Multimer Assembled on Icosahedral Closo-Borane Motif as High-Performance MRI Blood Pool Contrast Agent

2021 ◽  
Author(s):  
Lalit N. Goswami ◽  
Shatadru Chakravarty ◽  
Quan-Yu Cai ◽  
Erik M. Shapiro ◽  
M. Frederick Hawthorne ◽  
...  
Keyword(s):  
Contrast Agent ◽  
High Performance ◽  
Blood Pool ◽  
Blood Pool Contrast Agent

High-Spatial-Resolution Multistation MR Angiography with Parallel Imaging and Blood Pool Contrast Agent: Initial Experience

Radiology ◽  
2006 ◽  
Vol 241 (3) ◽  
pp. 861-872 ◽  
Author(s):  
Konstantin Nikolaou ◽  
Harald Kramer ◽  
Christina Grosse ◽  
Dirk Clevert ◽  
Olaf Dietrich ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Spatial Resolution ◽  
Mr Angiography ◽  
Parallel Imaging ◽  
High Spatial Resolution ◽  
Blood Pool ◽  
Initial Experience ◽  
Blood Pool Contrast Agent

scholarly journals Cerebral blood volume changes during the BOLD post-stimulus undershoot measured with a combined normoxia/hyperoxia method

NeuroImage ◽  
2019 ◽  
Vol 185 ◽  
pp. 154-163 ◽  
Author(s):  
Eulanca Y. Liu ◽  
Frank Haist ◽  
David J. Dubowitz ◽  
Richard B. Buxton
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Volume Changes

Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent

2017 ◽  
Vol 24 (6) ◽  
pp. 1348-1357 ◽  
Author(s):  
Andrej Babič ◽  
Vassily Vorobiev ◽  
Céline Xayaphoummine ◽  
Gaëlle Lapicorey ◽  
Anne-Sophie Chauvin ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Blood Pool ◽  
Blood Pool Contrast Agent ◽  
Self Assembled

scholarly journals Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrew A. Badachhape ◽  
Laxman Devkota ◽  
Igor V. Stupin ◽  
Poonam Sarkar ◽  
Mayank Srivastava ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Blood Volume ◽  
Placental Tissue ◽  
Blood Pool ◽  
Pregnant Mouse ◽  
Gadolinium Contrast ◽  
Vascular Perfusion ◽  
Post Contrast ◽  
Placental Perfusion ◽  
Contrast Enhanced

AbstractNon-invasive methods for estimating placental fractional blood volume (FBV) are of great interest for characterization of vascular perfusion in placentae during pregnancy to identify placental insufficiency that may be indicative of local ischemia or fetal growth restriction (FGR). Nanoparticle contrast-enhanced magnetic resonance imaging (CE-MRI) may enable direct placental FBV estimation and may provide a reliable, 3D alternative to assess maternal-side placental perfusion. In this pre-clinical study, we investigated if placental FBV at 14, 16, and 18 days of gestation could be estimated through contrast-enhanced MRI using a long circulating blood-pool liposomal gadolinium contrast agent that does not penetrate the placental barrier. Placental FBV estimates of 0.47 ± 0.06 (E14.5), 0.50 ± 0.04 (E16.5), and 0.52 ± 0.04 (E18.5) were found through fitting pre-contrast and post-contrast T1 values in placental tissue using a variable flip angle method. MRI-derived placental FBV was validated against nanoparticle contrast-enhanced computed tomography (CE-CT) derived placental FBV, where signal is directly proportional to the concentration of iodine contrast agent. The results demonstrate successful estimation of the placental FBV, with values statistically indistinguishable from the CT derived values.

Pre-clinical evaluation of a nanoparticle-based blood-pool contrast agent for MR imaging of the placenta

Placenta ◽  
2017 ◽  
Vol 57 ◽  
pp. 60-70 ◽  
Author(s):  
Ketan B. Ghaghada ◽  
Zbigniew A. Starosolski ◽  
Saakshi Bhayana ◽  
Igor Stupin ◽  
Chandreshkumar V. Patel ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Clinical Evaluation ◽  
Blood Pool ◽  
Blood Pool Contrast Agent

scholarly journals Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent

2011 ◽  
Vol 24 (10) ◽  
pp. 1313-1325 ◽  
Author(s):  
Jun Hua ◽  
Qin Qin ◽  
James J. Pekar ◽  
Peter C. M. van Zijl
Keyword(s):  
Human Brain ◽  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume
Sign in / Sign up

Export Citation Format

Share Document