scholarly journals Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent

2011 ◽  
Vol 24 (10) ◽  
pp. 1313-1325 ◽  
Author(s):  
Jun Hua ◽  
Qin Qin ◽  
James J. Pekar ◽  
Peter C. M. van Zijl
Keyword(s):  
Human Brain ◽  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume

scholarly journals Ferumoxytol enhanced resting state fMRI and relative cerebral blood volume mapping in normal human brain

NeuroImage ◽  
2013 ◽  
Vol 83 ◽  
pp. 200-209 ◽  
Author(s):  
Helen D'Arceuil ◽  
Alexandre Coimbra ◽  
Pamela Triano ◽  
Margaret Dougherty ◽  
Julie Mello ◽  
...  
Keyword(s):  
Human Brain ◽  
Blood Volume ◽  
Resting State ◽  
Cerebral Blood Volume ◽  
Resting State Fmri ◽  
Normal Human Brain ◽  
Relative Cerebral Blood Volume ◽  
Normal Human

Using microbubbles as an MRI contrast agent for the measurement of cerebral blood volume

2013 ◽  
Vol 26 (11) ◽  
pp. 1540-1546 ◽  
Author(s):  
Shin-Lei Peng ◽  
Fu-Nien Wang ◽  
Chung-Hsin Wang ◽  
Hsu-Hsia Peng ◽  
Chih-Tien Lu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Mri Contrast Agent ◽  
Mri Contrast

scholarly journals Absolute Cerebral Blood Volume and Blood Flow Measurements Based on Synchrotron Radiation Quantitative Computed Tomography

2003 ◽  
Vol 23 (4) ◽  
pp. 499-512 ◽  
Author(s):  
Jean-François Adam ◽  
Hélène Elleaume ◽  
Géraldine Le Duc ◽  
Stéphanie Corde ◽  
Anne-Marie Charvet ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Blood Flow ◽  
Synchrotron Radiation ◽  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Quantitative Computed Tomography ◽  
Contrast Material ◽  
Flow Measurements ◽  
Computed Tomography Images

Synchrotron radiation computed tomography opens new fields by using monochromatic x-ray beams. This technique allows one to measure in vivo absolute contrast-agent concentrations with high accuracy and precision, and absolute cerebral blood volume or flow can be derived from these measurements using tracer kinetic methods. The authors injected an intravenous bolus of an iodinated contrast agent in healthy rats, and acquired computed tomography images to follow the temporal evolution of the contrast material in the blood circulation. The first image acquired before iodine infusion was subtracted from the others to obtain computed tomography slices expressed in absolute iodine concentrations. Cerebral blood volume and cerebral blood flow maps were obtained after correction for partial volume effects. Mean cerebral blood volume and flow values (n = 7) were 2.1 ± 0.38 mL/100 g and 129 ± 18 mL · 100 g–1 · min–1 in the parietal cortex; and 1.92 ± 0.32 mL/100 g and 125 ± 17 mL · 100 g–1 · min–1 in the caudate putamen, respectively. Synchrotron radiation computed tomography has the potential to assess these two brain-perfusion parameters.

High-resolution cerebral blood volume imaging in humans using the blood pool contrast agent ferumoxytol

2012 ◽  
Vol 70 (3) ◽  
pp. 705-710 ◽  
Author(s):  
Thomas Christen ◽  
Wendy Ni ◽  
Deqiang Qiu ◽  
Heiko Schmiedeskamp ◽  
Roland Bammer ◽  
...  
Keyword(s):  
High Resolution ◽  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Blood Pool ◽  
Blood Pool Contrast Agent ◽  
Volume Imaging

scholarly journals MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain

NeuroImage ◽  
2014 ◽  
Vol 89 ◽  
pp. 262-270 ◽  
Author(s):  
T. Christen ◽  
N.A. Pannetier ◽  
W.W. Ni ◽  
D. Qiu ◽  
M.E. Moseley ◽  
...  
Keyword(s):  
Human Brain ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
New Approach

The post-stimulation undershoot in BOLD fMRI of human brain is not caused by elevated cerebral blood volume

NeuroImage ◽  
2008 ◽  
Vol 40 (2) ◽  
pp. 473-481 ◽  
Author(s):  
Jens Frahm ◽  
Jürgen Baudewig ◽  
Kai Kallenberg ◽  
Andreas Kastrup ◽  
K. Dietmar Merboldt ◽  
...  
Keyword(s):  
Human Brain ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Bold Fmri

In Vivo Determination of Absolute Cerebral Blood Volume Using Hemoglobin as a Natural Contrast Agent: An MRI Study Using Altered Arterial Carbon Dioxide Tension

1999 ◽  
Vol 19 (7) ◽  
pp. 809-817 ◽  
Author(s):  
John A. Ulatowski ◽  
Joni M. E. Oja ◽  
Jose I. Suarez ◽  
Risto A. Kauppinen ◽  
Richard J. Traystman ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Carbon Dioxide ◽  
White Matter ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Spin Echo ◽  
Blood Oxygenation ◽  
Resonance Imaging

The ability of the magnetic resonance imaging transverse relaxation time, R2 = 1/T2, to quantify cerebral blood volume (CBV) without the need for an exogenous contrast agent was studied in cats (n = 7) under pentobarbital anesthesia. This approach is possible because R2 is directly affected by changes in CBF, CBV, CMRO2, and hematocrit (Hct), a phenomena better known as the blood-oxygenation-level-dependent (BOLD) effect. Changes in CBF and CBV were accomplished by altering the carbon dioxide pressure, Paco2, over a range from 20 to 140 mm Hg. For each Paco2 value, R2 in gray and white matter were determined using MRI, and the whole-brain oxygen extraction ratio was obtained from arteriovenous differences (sagittal sinus catheter). Assuming a constant CMRO2, the microvascular CBV was obtained from an exact fit to the BOLD theory for the spin-echo effect. The resulting CBV values at normal Paco2 and normalized to a common total hemoglobin concentration of 6.88 mmol/L were 42 ±18 μL/g (n = 7) and 29 ±19 μL/g (n = 5) for gray and white matter, respectively, in good agreement with the range of literature values published using independent methodologies. The present study confirms the validity of the spin-echo BOLD theory and, in addition, shows that blood volume can be quantified from the magnetic resonance imaging spin relaxation rate R2 using a regulated carbon dioxide experiment.

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