A Short‐Term Western Diet Impairs Cholesterol Homeostasis and Key Players of Beta Amyloid Metabolism in Brain of Middle Aged Rats

2020 ◽  
Vol 64 (16) ◽  
pp. 2000541 ◽  
Author(s):  
Maria Stefania Spagnuolo ◽  
Valentina Pallottini ◽  
Arianna Mazzoli ◽  
Lucia Iannotta ◽  
Claudia Tonini ◽  
...  
Keyword(s):  
Beta Amyloid ◽  
Western Diet ◽  
Cholesterol Homeostasis ◽  
Aged Rats ◽  
Middle Aged ◽  
Short Term ◽  
Key Players ◽  
Amyloid Metabolism

scholarly journals Early Hepatic Oxidative Stress and Mitochondrial Changes Following Western Diet in Middle Aged Rats

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2670 ◽  
Author(s):  
Arianna Mazzoli ◽  
Raffaella Crescenzo ◽  
Luisa Cigliano ◽  
Maria Stefania Spagnuolo ◽  
Rosa Cancelliere ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Dietary Habits ◽  
Western Diet ◽  
Hepatic Insulin Resistance ◽  
Whole Body ◽  
Myeloperoxidase Activity ◽  
Aged Rats ◽  
Middle Aged ◽  
Markers Of Oxidative Stress

To assess the effect of 4 weeks of high fat-high fructose feeding on whole body composition, energy balance, specific markers of oxidative stress and inflammation, and insulin sensitivity in the liver of middle-aged rats, rats (1 year) were fed a diet rich in saturated fatty acids and fructose (HFF rats), mimicking the “Western diet”, and compared with rats of the same age that were fed a low fat diet (LF rats). HFF rats exhibited a significant increase in the gain of body weight, energy, and lipids compared to LF rats. HFF rats also showed hepatic insulin resistance, together with an increase in plasma triglycerides, cholesterol, and tumor necrosis factor alpha. Hepatic lipids, triglycerides and cholesterol were higher in HFF rats, while a significant decrease in Stearoyl-CoA desaturase activity was found in this tissue. A marked increase in the protein amount of complex I, concomitant to a decrease in its contribution to mitochondrial respiration, was found in HFF rats. Lipid peroxidation and Nitro-Tyrosine content, taken as markers of oxidative stress, as well as NADPH oxidase activity, were significantly higher in HFF rats, while the antioxidant enzyme catalase decreased in these rats. Myeloperoxidase activity and lipocalin content increased, while peroxisome proliferator activated receptor gamma decreased in HFF rats. The present results provide evidence that middle-aged rats show susceptibility to a short-term “Western diet”, exhibiting altered redox homeostasis, insulin resistance, and early mitochondrial alterations in the liver. Therefore, this type of dietary habits should be drastically limited to pursue a “healthy aging”.

Protective Effects of Exercise Training Against Aged Induced the Reduction of Cardiac Angiogenic Capacity in Middle Aged Rats

2020 ◽  
Vol 04 (01) ◽  
Author(s):  
Titiporn Mekrungruangwong ◽  
Pimpetch Kasetsuwan ◽  
Sheepsumon Viboolvorakul ◽  
Suthiluk Patumraj
Keyword(s):  
Exercise Training ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Klaske Oberman ◽  
Iris Hovens ◽  
Jacco de Haan ◽  
Joana Falcao-Salles ◽  
Barbara van Leeuwen ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Morris Water Maze ◽  
Rat Model ◽  
Gut Microbiome ◽  
Water Maze ◽  
Single Injection ◽  
Postoperative Cognitive Dysfunction ◽  
Aged Rats ◽  
Short Term ◽  
Term Memory

Abstract Background Inflammation is considered a key factor in the development of postoperative cognitive dysfunction (POCD). Therefore, we hypothesized that pre-operative anti-inflammatory treatment with ibuprofen would inhibit POCD in our rat-model. Methods Male Wistar rats of 3 or 23 months old received a single injection of ibuprofen (15 mg/kg i.p.) or were control handled before abdominal surgery. Timed blood and fecal samples were collected for analyses of inflammation markers and gut microbiome changes. Behavioral testing was performed from 9 to 14 days after surgery, in the open field, novel object- and novel location-recognition tests and Morris water maze. Neuroinflammation and neurogenesis were assessed by immune histochemistry after sacrifice on postoperative day 14. Results Ibuprofen improved short-term spatial memory in the novel location recognition test, and increased hippocampal neurogenesis. However, these effects were associated with increased hippocampal microglia activity. Whereas plasma cytokine levels (IL1-β, IL6, IL10, and TNFα) were not significantly affected, VEGF levels increased and IFABP levels decreased after ibuprofen. Long-term memory in the Morris water maze was not significantly improved by ibuprofen. The gut microbiome was neither significantly affected by surgery nor by ibuprofen treatment. In general, effects in aged rats appeared similar to those in young rats, though less pronounced. Conclusion A single injection of ibuprofen before surgery improved hippocampus-associated short-term memory after surgery and increased neurogenesis. However, this favorable outcome seemed not attributable to inhibition of (neuro)inflammation. Potential contributions of intestinal and blood-brain barrier integrity need further investigation. Although less pronounced compared to young rats, effects in aged rats indicate that even elderly individuals could benefit from ibuprofen treatment.

TNF signaling via TNF receptors does not mediate the effects of short-term exercise on cognition, anxiety and depressive-like behaviors in middle-aged mice

2021 ◽  
pp. 113269
Author(s):  
Gaurav Singhal ◽  
Magdalene C. Jawahar ◽  
Julie Morgan ◽  
Frances Corrigan ◽  
Emily J. Jaehne ◽  
...  
Keyword(s):  
Tnf Receptors ◽  
Middle Aged ◽  
Short Term ◽  
Aged Mice

scholarly journals Impairment of Host Liver Repopulation by Transplanted Hepatocytes in Aged Rats and the Release by Short-Term Growth Hormone Treatment

2017 ◽  
Vol 187 (3) ◽  
pp. 553-569 ◽  
Author(s):  
Peggy Stock ◽  
Maximilian Bielohuby ◽  
Martin S. Staege ◽  
Mei-Ju Hsu ◽  
Martin Bidlingmaier ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Aged Rats ◽  
Host Liver ◽  
Short Term ◽  
Liver Repopulation

Estrogen, beta-Amyloid Metabolism/Trafficking, and Alzheimer's Disease

2006 ◽  
Vol 1089 (1) ◽  
pp. 324-342 ◽  
Author(s):  
H. XU ◽  
R. WANG ◽  
Y.-W. ZHANG ◽  
X. ZHANG
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Amyloid ◽  
Amyloid Metabolism
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