scholarly journals n‐3 PUFA Supplementation Alters Retinal Very‐Long‐Chain‐PUFA Levels and Ratios in Diabetic Animal Models

2019 ◽  
Vol 63 (15) ◽  
pp. 1801058 ◽  
Author(s):  
Aruna Gorusupudi ◽  
Fu‐Yen Chang ◽  
Kelly Nelson ◽  
Gregory S. Hageman ◽  
Paul S. Bernstein
Keyword(s):  
Animal Models ◽  
Diabetic Animal ◽  
Pufa Supplementation ◽  
Chain Pufa ◽  
Long Chain

scholarly journals Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats

2014 ◽  
Vol 112 (11) ◽  
pp. 1805-1818 ◽  
Author(s):  
Anne Létondor ◽  
Benjamin Buaud ◽  
Carole Vaysse ◽  
Laurence Fonseca ◽  
Coralie Herrouin ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Brain Regions ◽  
Erythrocyte Membranes ◽  
Aged Rats ◽  
Pufa Supplementation ◽  
Brain Functions ◽  
Chain Pufa ◽  
Brain Ageing ◽  
The Relationship ◽  
Long Chain

n-3 Long-chain PUFA (n-3 LC-PUFA), particularly EPA and DHA, play a key role in the maintenance of brain functions such as learning and memory that are impaired during ageing. Ageing is also associated with changes in the DHA content of brain membranes that could contribute to memory impairment. Limited studies have investigated the effects of ageing and n-3 LC-PUFA supplementation on both blood and brain fatty acid compositions. Therefore, we assessed the relationship between fatty acid contents in plasma and erythrocyte membranes and those in the hippocampus, striatum and cerebral cortex during ageing, and after a 5-month period of EPA/DHA supplementation in rats. In the blood, ageing was associated with an increase in plasma DHA content, whereas the DHA content remained stable in erythrocyte membranes. In the brain, ageing was associated with a decrease in DHA content, which was both region-specific and phospholipid class-specific. In EPA/DHA-supplemented aged rats, DHA contents were increased both in the blood and brain compared with the control rats. The present results demonstrated that n-3 LC-PUFA level in the plasma was not an accurate biomarker of brain DHA status during ageing. Moreover, we highlighted a positive relationship between the DHA levels in erythrocyte phosphatidylethanolamine (PE) and those in the hippocampus and prefrontal cortex in EPA/DHA-supplemented aged rats. Within the framework of preventive dietary supplementation to delay brain ageing, these results suggest the possibility of using erythrocyte PE DHA content as a reliable biomarker of DHA status in specific brain regions.

The effect of vitamin E and long-chain polyunsaturated fatty acid supplementation of pregnant and lactating ewes on the transfer of vitamin E to the lamb

2003 ◽  
Vol 2003 ◽  
pp. 61-61
Author(s):  
J. L. Capper ◽  
R. G. Wilkinson ◽  
E. Kasapidou ◽  
S. E. Pattinson ◽  
A. M. Mackenzie ◽  
...  
Keyword(s):  
Vitamin E ◽  
Maternal Diet ◽  
Dietary Vitamin ◽  
Chain Polyunsaturated Fatty Acid ◽  
Biochemical Mechanism ◽  
Pufa Supplementation ◽  
Fatty Acid Supplementation ◽  
Chain Pufa ◽  
Vitamin E Status ◽  
Long Chain

It is reported that supplementing pregnant ewes with supra-optimal levels of vitamin E improves neonatal lamb vigour and growth rate (Merrell, 1998). The biochemical mechanism behind these observations has yet to be elucidated as several studies report negligible placental vitamin E transfer in ruminants (Van Saun et al., 1989); consequently, lambs may be clinically deficient in this nutrient at birth and achieve a satisfactory vitamin E status via colostrum ingestion. Lamb vitamin E status may be further diminished by the addition of polyunsaturated fatty acids (PUFAs) to the maternal diet. However, PUFA supplementation demonstrably enhances foetal and neonatal development in human studies (Morley, 1998) although these effects have not been investigated in ruminants to any depth. The objective of this experiment was to investigate the effects of dietary vitamin E in combination with long-chain PUFA supplementation of ewes on ewe and lamb performance.

scholarly journals Maternal long-chain PUFA supplementation during protein deficiency improves brain fatty acid accretion in rat pups by altering the milk fatty acid composition of the dam

2013 ◽  
Vol 2 ◽  
Author(s):  
Prachi S. Ranade ◽  
Shobha S. Rao
Keyword(s):  
Fatty Acid ◽  
Docosapentaenoic Acid ◽  
Milk Fatty Acid ◽  
Brain Lipids ◽  
Pufa Supplementation ◽  
Chain Pufa ◽  
Rat Pups ◽  
Low Protein ◽  
The Brain ◽  
Long Chain

AbstractLong-chain PUFA (LC-PUFA) are important for fetal and neonatal brain development. However, their accretion in the brain is compromised during maternal protein restriction. Hence, we investigated the effect of maternal supplementation with n-3 DHA plus n-6 arachidonic acid (ARA) at a low protein level (9 %) on offspring brain fatty acid accretion using Wistar rats (nine rats per group) randomly fed a control (C), a low-protein (LP) or a low-protein DHA + ARA-supplemented (LPS) diet during gestation and lactation. At birth, pups from the LPS group had the highest brain DHA and n-3 fatty acid levels (P = 0·001), whereas pups from the LP group had the highest MUFA (P = 0·05) but the lowest DHA and total n-3 PUFA levels (P = 0·000). During lactation, pups from the LPS group accrued significantly more α-linolenic acid (P = 0·003), EPA (P = 0·02) and DHA (P = 0·000) in brain lipids than pups from the LP group, whereas brain lipids of pups from the LP group had markedly increased levels of the n-3 deficiency marker docosapentaenoic acid and n-6:n-3 ratio (P = 0·000). Owing to supplementation, milk from LPS dams had the highest DHA and ARA, but lower SCFA and medium-chain fatty acids as compared with milk from C and LP dams during early lactation, but normalised by mid-lactation. To conclude, adverse effects of restricted maternal protein intake on LC-PUFA accretion in the brain of offspring were ameliorated by alterations in maternal milk fatty acid profile due to supplementation. Results underscore the importance of LC-PUFA for protein-deficient mothers during gestation as well as lactation to achieve the optimum brain LC-PUFA status of progeny.

Long-chain PUFA supplementation improves PUFA profile in infants with cholestasis

Lipids ◽  
2002 ◽  
Vol 37 (10) ◽  
pp. 953-957 ◽  
Author(s):  
Piotr Socha ◽  
Berthold Koletzko ◽  
Irena Jankowska ◽  
Joanna Pawlowska ◽  
Hans Demmelmair ◽  
...  
Keyword(s):  
Pufa Supplementation ◽  
Chain Pufa ◽  
Long Chain

scholarly journals No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial – reply by Rogers et al.

2008 ◽  
Vol 100 (6) ◽  
pp. 1349-1351 ◽  
Author(s):  
Peter J. Rogers ◽  
Katherine M. Appleton ◽  
David Kessler ◽  
Tim J. Peters ◽  
David Gunnell ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cognitive Function ◽  
Randomised Controlled Trial ◽  
Depressed Mood ◽  
Controlled Trial ◽  
Chain Polyunsaturated Fatty Acid ◽  
Pufa Supplementation ◽  
Chain Pufa ◽  
Randomised Controlled ◽  
Long Chain

We recently reported a null outcome from a study of n-3 long-chain PUFA supplementation in depressed mood(1).

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