The Protective Activities of Dietary Sea Cucumber Cerebrosides against Atherosclerosis through Regulating Inflammation and Cholesterol Metabolism in Male Mice

2018 ◽  
Vol 62 (16) ◽  
pp. 1800315 ◽  
Author(s):  
Lingyu Zhang ◽  
Tiantian Zhang ◽  
Lin Ding ◽  
Jie Xu ◽  
Changhu Xue ◽  
...  
Keyword(s):  
Sea Cucumber ◽  
Cholesterol Metabolism ◽  
Male Mice

scholarly journals Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice

2019 ◽  
Vol 149 (3) ◽  
pp. 416-421 ◽  
Author(s):  
Stephanie G Harshman ◽  
M Kyla Shea ◽  
Xueyan Fu ◽  
Michael A Grusak ◽  
Donald Smith ◽  
...  
Keyword(s):  
Linear Models ◽  
Cholesterol Metabolism ◽  
Atmospheric Pressure Chemical Ionization ◽  
Control Diet ◽  
Male Mice ◽  
Atorvastatin Treatment ◽  
Treatment Groups ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical ◽  
Coa Reductase

ABSTRACTBackgroundMenaquinone-4 (MK4), a vitamin K metabolite, is converted from phylloquinone through a process that requires intermediates of endogenous cholesterol production. Recent evidence suggests that MK4 is involved in kidney function.ObjectiveThe purpose of this study was to determine the effect of atorvastatin treatment on MK4 formation in young and old male mice.MethodsC57BL/6 male mice (4-mo-old and 20-mo-old) were randomly assigned to either a diet containing 300 mg atorvastatin/kg with 3 mg phylloquinone/kg or a control diet containing 3 mg phylloquinone/kg for 8 wk. During week 8, all mice received deuterium-labeled phylloquinone in the diet. Labeled and unlabeled phylloquinone and MK4 in liver, kidney, brain, and intestine were measured by atmospheric pressure chemical ionization LC/MS. 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase gene expression was quantified by reverse transcriptase-PCR. Tissue MK4 and phylloquinone concentrations were compared between atorvastatin treatment groups with use of general linear models.ResultsThere was no age-treatment interaction on MK4 tissue concentrations. In atorvastatin-treated mice, total MK4 and percentage of deuterium-labeled MK4 in kidney were both approximately 45% lower compared to values in mice not given atorvastatin (all P < 0.05). MK4 concentrations did not differ between groups in any other tissue measured.ConclusionIn male mice, atorvastatin reduced endogenous MK4 formation in the kidney, but not other organs. These observations are consistent with our hypothesis that cholesterol metabolism is involved in the generation of MK4. Further research is needed to understand potential regulatory mechanisms and the unique functions of MK4 in the kidney.

scholarly journals Soat2 ties cholesterol metabolism to β‐oxidation and glucose tolerance in male mice

2022 ◽  
Author(s):  
Camilla Pramfalk ◽  
Osman Ahmed ◽  
Matteo Pedrelli ◽  
Mirko E. Minniti ◽  
Serge Luquet ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Cholesterol Metabolism ◽  
Male Mice

Sterol sulfate alleviates atherosclerosis via mediating hepatic cholesterol metabolism in ApoE-/- mice

2021 ◽  
Author(s):  
Lin Ding ◽  
Zhenjing Xu ◽  
Hao-hao Shi ◽  
Changhu Xue ◽  
Qingrong Huang ◽  
...  
Keyword(s):  
Sea Cucumber ◽  
Cholesterol Metabolism ◽  
Sulfate Group ◽  
Hepatic Cholesterol ◽  
Dietary Sterol

Compared with terrestrial organisms, the sterol in sea cucumber exhibit a sulfate group at C-3 position. Our previous study demonstrated that dietary sterol sulfate was superior to phytosterol in alleviating...

scholarly journals Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase

2009 ◽  
Vol 297 (2) ◽  
pp. E375-E383 ◽  
Author(s):  
Ayala Luria ◽  
Christophe Morisseau ◽  
Hsing-Ju Tsai ◽  
Jun Yang ◽  
Bora Inceoglu ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Cholesterol Metabolism ◽  
Sperm Count ◽  
Physiological Role ◽  
Soluble Epoxide Hydrolase ◽  
Plasma Testosterone ◽  
Null Mouse ◽  
Male Mice ◽  
Testosterone Levels ◽  
Wide Range

Soluble epoxide hydrolase ( Ephx2, sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH2-terminal phosphatase activities. sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), and the phosphatase activity is suggested to be involved in cholesterol metabolism. EETs participate in a wide range of biological functions, including regulation of vascular tone, renal tubular transport, cardiac contractility, and inflammation. Inhibition of sEH is a potential approach for enhancing the biological activity of EETs. Therefore, disruption of sEH activity is becoming an attractive therapeutic target for both cardiovascular and inflammatory diseases. To define the physiological role of sEH, we characterized a knockout mouse colony lacking expression of the Ephx2 gene. Lack of sEH enzyme is characterized by elevation of EET to DHET ratios in both the linoleate and arachidonate series in plasma and tissues of both female and male mice. In male mice, this lack of expression was also associated with decreased plasma testosterone levels, sperm count, and testicular size. However, this genotype was still able to sire litters. Plasma cholesterol levels also declined in this genotype. Behavior tests such as anxiety-like behavior and hedonic response were also examined in Ephx2-null and WT mice, as all can be related to hormonal changes. Null mice showed a level of anxiety with a decreased hedonic response. In conclusion, this study provides a broad biochemical, physiological, and behavioral characterization of the Ephx2-null mouse colony and suggests a mechanism by which sEH and its substrates may regulate circulating levels of testosterone through cholesterol biosynthesis and metabolism.

Ultrastructural Lesions Produced by Alcohol and Sucrose in the Heart and Liver of C57BL Mice

1970 ◽  
Vol 28 ◽  
pp. 208-209
Author(s):  
K.K. SEKHRI ◽  
C.S. ALEXANDER ◽  
H.T. NAGASAWA
Keyword(s):  
Osmium Tetroxide ◽  
Male Mice ◽  
Alcohol Group ◽  
Group Iii ◽  
Group I ◽  
C57bl Mice ◽  
Group Ii

C57BL male mice (Jackson Lab., Bar Harbor, Maine) weighing about 18 gms were randomly divided into three groups: group I was fed sweetened liquid alcohol diet (modified Schenkl) in which 36% of the calories were derived from alcohol; group II was maintained on a similar diet but alcohol was isocalorically substituted by sucrose; group III was fed regular mouse chow ad lib for five months. Liver and heart tissues were fixed in 2.5% cacodylate buffered glutaraldehyde, post-fixed in 2% osmium tetroxide and embedded in Epon-araldite.

1859: The Histone Deycetylase Inhibitor Trichostatin-a Arrests Meiosis in Male Mice

2007 ◽  
Vol 177 (4S) ◽  
pp. 617-617
Author(s):  
Klaus Steger ◽  
Irina Fenic ◽  
Hamid M. Hossain ◽  
Violetta Sonnack ◽  
Svetlin Tchatalbachev ◽  
...  
Keyword(s):  
Trichostatin A ◽  
Male Mice

1625: Role of Estrogen Receptor β in the Regulation of Sexual Behavior in Male Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 429-429
Author(s):  
Masayoshi Nomura ◽  
Naohiro Fujimoto ◽  
Donald W. Pfaff ◽  
Sonoko Ogawa ◽  
Tetsuro Matsumoto
Keyword(s):  
Estrogen Receptor ◽  
Sexual Behavior ◽  
Estrogen Receptor Β ◽  
Male Mice

Author response for "Enriched environment enhances NK cell maturation through hypothalamic BDNF in male mice"

2020 ◽  
Author(s):  
Anthony G. Mansour ◽  
Run Xiao ◽  
Stephen M Bergin ◽  
Wei Huang ◽  
Logan A. Chrislip ◽  
...  
Keyword(s):  
Nk Cell ◽  
Enriched Environment ◽  
Cell Maturation ◽  
Author Response ◽  
Male Mice
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