Anthocyanin extracts of lingonberry ( Vaccinium vitis‐idaea L.) attenuate serum lipids and cholesterol metabolism in HCD ‐induced hypercholesterolaemic male mice

2018 ◽  
Vol 54 (5) ◽  
pp. 1576-1587 ◽  
Author(s):  
Zi‐cheng Zhang ◽  
Qing Zhou ◽  
Gu‐yu Huangfu ◽  
Ying Wu ◽  
Jiu‐liang Zhang
Keyword(s):  
Serum Lipids ◽  
Cholesterol Metabolism ◽  
Male Mice

The Protective Activities of Dietary Sea Cucumber Cerebrosides against Atherosclerosis through Regulating Inflammation and Cholesterol Metabolism in Male Mice

2018 ◽  
Vol 62 (16) ◽  
pp. 1800315 ◽  
Author(s):  
Lingyu Zhang ◽  
Tiantian Zhang ◽  
Lin Ding ◽  
Jie Xu ◽  
Changhu Xue ◽  
...  
Keyword(s):  
Sea Cucumber ◽  
Cholesterol Metabolism ◽  
Male Mice

scholarly journals Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice

2019 ◽  
Vol 149 (3) ◽  
pp. 416-421 ◽  
Author(s):  
Stephanie G Harshman ◽  
M Kyla Shea ◽  
Xueyan Fu ◽  
Michael A Grusak ◽  
Donald Smith ◽  
...  
Keyword(s):  
Linear Models ◽  
Cholesterol Metabolism ◽  
Atmospheric Pressure Chemical Ionization ◽  
Control Diet ◽  
Male Mice ◽  
Atorvastatin Treatment ◽  
Treatment Groups ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical ◽  
Coa Reductase

ABSTRACTBackgroundMenaquinone-4 (MK4), a vitamin K metabolite, is converted from phylloquinone through a process that requires intermediates of endogenous cholesterol production. Recent evidence suggests that MK4 is involved in kidney function.ObjectiveThe purpose of this study was to determine the effect of atorvastatin treatment on MK4 formation in young and old male mice.MethodsC57BL/6 male mice (4-mo-old and 20-mo-old) were randomly assigned to either a diet containing 300 mg atorvastatin/kg with 3 mg phylloquinone/kg or a control diet containing 3 mg phylloquinone/kg for 8 wk. During week 8, all mice received deuterium-labeled phylloquinone in the diet. Labeled and unlabeled phylloquinone and MK4 in liver, kidney, brain, and intestine were measured by atmospheric pressure chemical ionization LC/MS. 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase gene expression was quantified by reverse transcriptase-PCR. Tissue MK4 and phylloquinone concentrations were compared between atorvastatin treatment groups with use of general linear models.ResultsThere was no age-treatment interaction on MK4 tissue concentrations. In atorvastatin-treated mice, total MK4 and percentage of deuterium-labeled MK4 in kidney were both approximately 45% lower compared to values in mice not given atorvastatin (all P < 0.05). MK4 concentrations did not differ between groups in any other tissue measured.ConclusionIn male mice, atorvastatin reduced endogenous MK4 formation in the kidney, but not other organs. These observations are consistent with our hypothesis that cholesterol metabolism is involved in the generation of MK4. Further research is needed to understand potential regulatory mechanisms and the unique functions of MK4 in the kidney.

scholarly journals Soat2 ties cholesterol metabolism to β‐oxidation and glucose tolerance in male mice

2022 ◽  
Author(s):  
Camilla Pramfalk ◽  
Osman Ahmed ◽  
Matteo Pedrelli ◽  
Mirko E. Minniti ◽  
Serge Luquet ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Cholesterol Metabolism ◽  
Male Mice

Abstract 18611: Increased Absorption and Decreased Synthesis of Cholesterol in Cardiac Sarcoidosis

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Piia Simonen ◽  
Jukka Lehtonen ◽  
Helena Gylling ◽  
Markku Kupari
Keyword(s):  
Serum Lipids ◽  
Cardiac Sarcoidosis ◽  
Cholesterol Metabolism ◽  
Immunosuppressive Treatment ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Cholesterol Absorption ◽  
Immunosuppressive Drugs ◽  
Serum Markers ◽  
Gas Liquid Chromatography

Introduction: Sarcoidosis is a multisystem inflammatory disease characterised by the formation of granulomas in many tissues. Some reports suggest that the disease is associated with altered lipoprotein cholesterol profiles, but there is no deeper knowledge of cholesterol metabolism in these patients. Hypothesis: We tested the hypothesis that cholesterol metabolism is abnormal in cardiac sarcoidosis (CS). Methods: The study population consisted of 39 patients with histologically verified CS (31 women and 8 men, mean age 53 years) and 124 healthy controls of similar age and gender. 31 of the CS patients were on immunosuppressive treatment. Serum lipids were determined and cholesterol metabolism was evaluated by measuring serum markers of cholesterol absorption (cholestanol, campesterol and sitosterol) and synthesis (desmosterol and lathosterol) as ratios to cholesterol with gas-liquid chromatography. Results: CS was inactive in all patients based on clinical evaluation, cardiac ultrasound, and stable levels of serum TnT and proBNP. Serum total, LDL and HDL cholesterol concentrations (mean±SE) were 5.6±0.2, 3.3±0.1 and 1.5±0.1 mmol/l, respectively, and serum triglyceride averaged 1.7±0.7 mmol/l. These values did not differ from those of controls. Cholesterol absorption markers were higher in CS patients than in controls (eg. serum campesterol level 245±17 vs 190±17 10 2 μmol/mmol of cholesterol, p<0.05). Cholesterol synthesis markers were lower in CS patients than in controls (eg. serum lathosterol level102±8 vs 195±17 10 2 μmol/mmol of cholesterol, p<0.001). Concentrations of serum lipids and non-cholesterol sterols did not associate with the use of immunosuppressive drugs. Markers of cholesterol absorption and synthesis did not correlate with serum TnT levels, but there was a significant positive correlation between proBNP and cholesterol absorption markers (r=0.351, p<0.05). Conclusions: We conclude that, in CS, cholesterol absorption is increased and its synthesis is decreased. The underlying mechanisms remain obscure and deserve further study. This is the first time that abnormal cholesterol metabolism has been described in CS.

scholarly journals EFFECTS OF VITAMIN B12 ON SERUM LIPIDS AND LIPOPROTEINS OF PIGS FED DIETS SUPPLEMENTED WITH PROPIONIC ACID OR CALCIUM PROPIONATE

1982 ◽  
Vol 62 (2) ◽  
pp. 527-536 ◽  
Author(s):  
P.A. THACKER ◽  
J.P. BOWLAND ◽  
M. FENTON
Keyword(s):  
Propionic Acid ◽  
Feed Intake ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Cholesterol Metabolism ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Vitamin B ◽  
Calcium Propionate ◽  
Lipids And Lipoproteins

Effects of vitamin B12 supplementation of diets containing propionic acid (PA), or calcium propionate (CP) on feed intake, serum lipids and lipoproteins were studied utilizing 80 crossbred pigs averaging 22.5 kg. Diets, based on barley-soybean meal, containing 0, 3.5 or 7% PA or CP, were fed with and without the addition of 4.95 mg vitamin B12/kg diet. Inclusion of PA or CP with or without the addition of vitamin B12 had no significant effect on feed intake. Addition of PA or CP depressed serum cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and serum triglycerides. Vitamin B12 supplementation had no effect on serum total cholesterol or HDL cholesterol, caused a reduction in LDL cholesterol, and tended to overcome the reduction in serum triglyceride. Supplementation of diets with vitamin B12 reduced liver lipid levels, largely as a result of a decrease in cholesterol and phospholipids. These data suggest that the cholesterol-lowering effect of PA is not simply a result of a depression in feed intake, but arises from a direct action of PA on cholesterol metabolism. Key words: Vitamin B12, lipids, lipo protein, pigs, propionic, propionate

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