Sterol sulfate alleviates atherosclerosis via mediating hepatic cholesterol metabolism in ApoE-/- mice

2021 ◽  
Author(s):  
Lin Ding ◽  
Zhenjing Xu ◽  
Hao-hao Shi ◽  
Changhu Xue ◽  
Qingrong Huang ◽  
...  
Keyword(s):  
Sea Cucumber ◽  
Cholesterol Metabolism ◽  
Sulfate Group ◽  
Hepatic Cholesterol ◽  
Dietary Sterol

Compared with terrestrial organisms, the sterol in sea cucumber exhibit a sulfate group at C-3 position. Our previous study demonstrated that dietary sterol sulfate was superior to phytosterol in alleviating...

scholarly journals Hepatic cholesterol metabolism in cholesterol gallstone disease

1991 ◽  
Vol 32 (3) ◽  
pp. 469-475
Author(s):  
E Reihnér ◽  
B Angelin ◽  
I Björkhem ◽  
K Einarsson
Keyword(s):  
Cholesterol Metabolism ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Hepatic Cholesterol

scholarly journals Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.

1979 ◽  
Vol 20 (1) ◽  
pp. 107-115
Author(s):  
J Ahlberg ◽  
B Angelin ◽  
I Björkhem ◽  
K Einarsson ◽  
B Leijd
Keyword(s):  
Cholesterol Metabolism ◽  
Hepatic Cholesterol ◽  
Cholesterol Gallstones

scholarly journals Short- and long-term effects of biliary drainage on hepatic cholesterol metabolism in the rat

1990 ◽  
Vol 269 (3) ◽  
pp. 781-788 ◽  
Author(s):  
M J Smit ◽  
A M Temmerman ◽  
R Havinga ◽  
F Kuipers ◽  
R J Vonk
Keyword(s):  
Bile Acid ◽  
Bile Flow ◽  
Cholesterol Metabolism ◽  
Acid Output ◽  
Biliary Secretion ◽  
Surgical Trauma ◽  
Hepatic Cholesterol ◽  
Long Term Effects ◽  
Short And Long Term

The present study concerns short- and long-term effects of interruption of the enterohepatic circulation (EHC) on hepatic cholesterol metabolism and biliary secretion in rats. For this purpose, we employed a technique that allows reversible interruption of the EHC, during normal feeding conditions, and excludes effects of anaesthesia and surgical trauma. [3H]Cholesteryl oleate-labelled human low-density lipoprotein (LDL) was injected intravenously in rats with (1) chronically (8 days) interrupted EHC, (2) interrupted EHC at the time of LDL injection and (3) intact EHC. During the first 3 h after interruption of the EHC, bile flow decreased to 50% and biliary bile acid, phospholipid and cholesterol secretion to 5%, 11% and 19% of their initial values respectively. After 8 days of bile diversion, biliary cholesterol output and bile flow were at that same level, but bile acid output was increased 2-3-fold and phospholipid output was about 2 times lower. The total amount of cholesterol in the liver decreased after interruption of the EHC, which was mainly due to a decrease in the amount of cholesteryl ester. Plasma disappearance of LDL was not affected by interruption of the EHC. Biliary secretion of LDL-derived radioactivity occurred 2-4 times faster in chronically interrupted rats as compared with the excretion immediately after interruption of the EHC. Radioactivity was mainly in the form of bile acids under both conditions. This study demonstrates the very rapid changes that occur in cholesterol metabolism and biliary lipid composition after interruption of the EHC. These changes must be taken into account in studies concerning hepatic metabolism of lipoprotein cholesterol and subsequent secretion into bile.

The influence of estrogen on hepatic cholesterol metabolism and biliary lipid secretion in rats fed fish oil

1999 ◽  
Vol 1437 (3) ◽  
pp. 367-377 ◽  
Author(s):  
Elena Bravo ◽  
Alfredo Cantafora ◽  
Carla Cicchini ◽  
Michael Avella ◽  
Kathleen M. Botham
Keyword(s):  
Fish Oil ◽  
Cholesterol Metabolism ◽  
Biliary Lipid ◽  
Hepatic Cholesterol ◽  
Lipid Secretion

scholarly journals Disruption of the Sterol Carrier Protein 2 Gene in Mice Impairs Biliary Lipid and Hepatic Cholesterol Metabolism

2001 ◽  
Vol 276 (51) ◽  
pp. 48058-48065 ◽  
Author(s):  
Michael Fuchs ◽  
Andrea Hafer ◽  
Christian Münch ◽  
Frank Kannenberg ◽  
Sandra Teichmann ◽  
...  
Keyword(s):  
Cholesterol Metabolism ◽  
Carrier Protein ◽  
Biliary Lipid ◽  
Sterol Carrier Protein ◽  
Hepatic Cholesterol ◽  
Sterol Carrier Protein 2

scholarly journals Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE−/− mice

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33122-33136 ◽  
Author(s):  
Nemanja Vujic ◽  
Melanie Korbelius ◽  
Christina Leopold ◽  
Madalina Duta-Mare ◽  
Silvia Rainer ◽  
...  
Keyword(s):  
Cholesterol Metabolism ◽  
Hepatic Cholesterol ◽  
Monoglyceride Lipase
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