Nutrition in the genomics era: Cardiovascular disease risk and the Mediterranean diet

2007 ◽  
Author(s):  
Jose M. Ordovas ◽  
Jim Kaput ◽  
Dolores Corella
Keyword(s):  
Cardiovascular Disease ◽  
Mediterranean Diet ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
The Mediterranean

Mediterranean Diet Reduces Atherosclerosis Progression in Coronary Heart Disease: An Analysis of the CORDIOPREV Randomized Controlled Trial

Stroke ◽  
2021 ◽  
Author(s):  
Jose Jimenez-Torres ◽  
Juan F. Alcalá-Diaz ◽  
Jose D. Torres-Peña ◽  
Francisco M. Gutierrez-Mariscal ◽  
Ana Leon-Acuña ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Olive Oil ◽  
Mediterranean Diet ◽  
Carotid Plaque ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Low Fat ◽  
Low Fat Diet ◽  
The Mediterranean

Background and Purpose: Lifestyle and diet affect cardiovascular risk, although there is currently no consensus about the best dietary model for the secondary prevention of cardiovascular disease. The CORDIOPREV study (Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention) is an ongoing prospective, randomized, single-blind, controlled trial in 1002 coronary heart disease patients, whose primary objective is to compare the effect of 2 healthy dietary patterns (low-fat rich in complex carbohydrates versus Mediterranean diet rich in extra virgin olive oil) on the incidence of cardiovascular events. Here, we report the results of one secondary outcome of the CORDIOPREV study. Thus, to evaluate the efficacy of these diets in reducing cardiovascular disease risk. Intima-media thickness of both common carotid arteries (IMT-CC) was ultrasonically assessed bilaterally. IMT-CC is a validated surrogate for the status and future cardiovascular disease risk. Methods: From the total participants, 939 completed IMT-CC evaluation at baseline and were randomized to follow a Mediterranean diet (35% fat, 22% monounsaturated fatty acids, <50% carbohydrates) or a low-fat diet (28% fat, 12% monounsaturated fatty acids, >55% carbohydrates) with IMT-CC measurements at 5 and 7 years. We also analyzed the carotid plaque number and height. Results: The Mediterranean diet decreased IMT-CC at 5 years (−0.027±0.008 mm; P <0.001), maintained at 7 years (−0.031±0.008 mm; P <0.001), compared to baseline. The low-fat diet did not modify IMT-CC. IMT-CC and carotid plaque max height were higher decreased after the Mediterranean diet, compared to the low-fat diet, throughout follow-up. Baseline IMT-CC had the strongest association with the changes in IMT-CC after the dietary intervention. Conclusions: Long-term consumption of a Mediterranean diet rich in extravirgin olive oil, if compared to a low-fat diet, was associated with decreased atherosclerosis progression, as shown by reduced IMT-CC and carotid plaque height. These findings reinforce the clinical benefits of the Mediterranean diet in the context of secondary cardiovascular prevention. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00924937.

Strong inverse associations of Mediterranean diet, physical activity and their combination with cardiovascular disease: The Seguimiento Universidad de Navarra (SUN) cohort

2018 ◽  
Vol 25 (11) ◽  
pp. 1186-1197 ◽  
Author(s):  
Ismael Alvarez-Alvarez ◽  
Javier Pérez de Rojas ◽  
Alejandro Fernandez-Montero ◽  
Itziar Zazpe ◽  
Miguel Ruiz-Canela ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Mediterranean Diet ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Hazard Ratio ◽  
Inverse Association ◽  
Active Lifestyle ◽  
The Mediterranean ◽  
Reduced Risk

Background Inverse associations of the Mediterranean diet (MedDiet) and physical activity with cardiovascular disease have been previously reported. We investigated the individual and combined contributions of both to this inverse association in a Mediterranean cohort. Design We used data from 19,536 participants from a prospective cohort of Spanish university graduates, the ‘Seguimiento Universidad de Navarra’ (SUN) cohort, followed up between December 1999 and December 2016. Methods Adherence to the MedDiet was obtained from a 136-item validated food-frequency questionnaire and categorized in tertiles using four previously reported dietary scores. A validated questionnaire assessed the physical activity levels according to volume, intensity and frequency. Results Participants were followed up during a median time of 10.4 years. Compared with the lowest category of adherence to the MedDiet (≤3 in the Mediterranean Diet Score), higher adherence (6–9 points) was strongly inversely associated with cardiovascular disease (multivariable adjusted hazard ratio = 0.33; 95% confidence interval (CI) 0.20–0.55). Also, engaging in an active lifestyle (6–8 points in an eight-item score) compared with low activity (<2 points) was associated with a reduced risk of incident cardiovascular disease (hazard ratio = 0.43; 95% CI 0.20–0.90). Greater adherence to the MedDiet and engaging in high levels of active lifestyle showed a 75% relatively reduced risk of cardiovascular disease (hazard ratio = 0.25; 95% CI 0.13–0.48). Conclusions The combined effect of adherence to the MedDiet and adopting an active lifestyle showed a synergistic inverse association with cardiovascular disease risk.

scholarly journals Adherence to Mediterranean diet has a mediating effect inflammation as regards cardiovascular disease risk: The 10-year (2002-12) follow-up of ATTICA study

2016 ◽  
Vol 13 ◽  
pp. e67 ◽  
Author(s):  
Ekavi N. Georgoysopoulou ◽  
Demosthenes B. Panagiotakos ◽  
Christos Pitsavos ◽  
Aikaterini Kalogeropoulou ◽  
Maria Ntertimani ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Mediterranean Diet ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Mediating Effect

scholarly journals Mediterranean diet and metabolic syndrome: the evidence

2009 ◽  
Vol 12 (9A) ◽  
pp. 1607-1617 ◽  
Author(s):  
Nancy Babio ◽  
Mònica Bulló ◽  
Jordi Salas-Salvadó
Keyword(s):  
Metabolic Syndrome ◽  
Mediterranean Diet ◽  
Fruits And Vegetables ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Atherogenic Dyslipidemia ◽  
Favourable Effect ◽  
Processed Meat ◽  
Beneficial Effects ◽  
The Mediterranean

AbstractBackgroundThe Mediterranean diet has long been related to a lower cardiovascular disease risk; however, more recent evidences also indicate that it has a favourable effect on adiposity and type 2 diabetes.DesignReview of the available literature in relation to Mediterranean diet and metabolic syndrome.ResultsSeveral components of Mediterranean diet patterns have been inversely related with body mass index. They are considered to be modulators of insulin resistance, can exert beneficial effects on blood pressure, improve atherogenic dyslipidemia or attenuate the inflammatory burden associated with metabolic syndrome. Furthermore, a lower prevalence of metabolic syndrome has been associated with dietary patterns rich in fruits and vegetables, nuts, olive oil, legumes and fish, moderate in alcohol and low in red meat, processed meat, refined carbohydrates and whole-fat dairy products.ConclusionsThere is much evidence suggesting that the Mediterranean diet could serve as an anti-inflammatory dietary pattern, which could help to fight diseases related to chronic inflammation, including metabolic syndrome.

scholarly journals Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function: The 2-Year Longitudinal Changes in an Older Spanish Cohort

2021 ◽  
Vol 13 ◽  
Author(s):  
Stephanie K. Nishi ◽  
Nancy Babio ◽  
Carlos Gómez-Martínez ◽  
Miguel Ángel Martínez-González ◽  
Emilio Ros ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cognitive Function ◽  
Cognitive Performance ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
A Priori ◽  
The Mediterranean ◽  
Overweight Or Obesity

Background and Aims: Plant-forward dietary patterns have been associated with cardiometabolic health benefits, which, in turn, have been related to cognitive performance with inconsistent findings. The objective of this study was to examine the relationship between baseline adherence to three a priori dietary patterns (Mediterranean, DASH, and MIND diets) with 2-year changes in cognitive performance in older adults with overweight or obesity and high cardiovascular disease risk.Methods: A prospective cohort analysis was conducted within the PREDIMED-Plus trial, involving 6,647 men and women aged 55–75 years with overweight or obesity and metabolic syndrome. Using a validated, semiquantitative 143-item food frequency questionnaire completed at baseline, the dietary pattern adherence scores were calculated. An extensive neuropsychological test battery was administered at baseline and 2-year follow-up. Multivariable-adjusted linear regression models were used to assess associations between 2-year changes in cognitive function z-scores across tertiles of baseline adherence to the a priori dietary patterns.Results: Adherence to the Mediterranean diet at baseline was associated with 2-year changes in the general cognitive screening Mini-Mental State Examination (MMSE, β: 0.070; 95% CI: 0.014, 0.175, P-trend = 0.011), and two executive function-related assessments: the Trail Making Tests Part A (TMT-A, β: −0.054; 95% CI: −0.110, − 0.002, P-trend = 0.047) and Part B (TMT-B, β: −0.079; 95% CI: −0.134, −0.024, P-trend = 0.004). Adherence to the MIND diet was associated with the backward recall Digit Span Test assessment of working memory (DST-B, β: 0.058; 95% CI: 0.002, 0.114, P-trend = 0.045). However, higher adherence to the DASH dietary pattern was not associated with better cognitive function over a period of 2 years.Conclusion: In older Spanish individuals with overweight or obesity and at high cardiovascular disease risk, higher baseline adherence to the Mediterranean dietary pattern may be associated with better cognitive performance than lower adherence over a period of 2 years.

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