Collagen nerve protector in rat sciatic nerve repair: A morphometric and histological analysis

Microsurgery ◽  
2010 ◽  
Vol 30 (5) ◽  
pp. 392-396 ◽  
Author(s):  
Paul D. Kim ◽  
Austin Hayes ◽  
Faiq Amin ◽  
Yelena Akelina ◽  
Arthur P. Hays ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Histological Analysis ◽  
Nerve Repair ◽  
Rat Sciatic Nerve

scholarly journals RGD-Modified Nanofibers Enhance Outcomes in Rats after Sciatic Nerve Injury

2019 ◽  
Vol 10 (2) ◽  
pp. 24 ◽  
Author(s):  
McKay Cavanaugh ◽  
Elena Silantyeva ◽  
Galina Pylypiv Koh ◽  
Elham Malekzadeh ◽  
William D. Lanzinger ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Histological Analysis ◽  
Nerve Repair ◽  
Repair Strategy ◽  
Rat Sciatic Nerve ◽  
Aligned Nanofibers ◽  
Sensory Recovery ◽  
Sensory Tests ◽  
Peptide Rgd

Nerve injuries requiring surgery are a significant problem without good clinical alternatives to the autograft. Tissue engineering strategies are critically needed to provide an alternative. In this study, we utilized aligned nanofibers that were click-modified with the bioactive peptide RGD for rat sciatic nerve repair. Empty conduits or conduits filled with either non-functionalized aligned nanofibers or RGD-functionalized aligned nanofibers were used to repair a 13 mm gap in the rat sciatic nerve of animals for six weeks. The aligned nanofibers encouraged cell infiltration and nerve repair as shown by histological analysis. RGD-functionalized nanofibers reduced muscle atrophy. During the six weeks of recovery, the animals were subjected to motor and sensory tests. Sensory recovery was improved in the RGD-functionalized nanofiber group by week 4, while other groups needed six weeks to show improvement after injury. Thus, the use of functionalized nanofibers provides cues that aid in in vivo nerve repair and should be considered as a future repair strategy.

scholarly journals Learning curve in rat dissection for experimental sciatic nerve repair

2019 ◽  
pp. 243-248
Author(s):  
Marin Andrei ◽  
Marin Georgiana Gabriela ◽  
Dobrete Nicoleta Amalia ◽  
Enescu Dan Mircea
Keyword(s):  
Sciatic Nerve ◽  
Learning Curve ◽  
Nerve Regeneration ◽  
Experimental Model ◽  
Rat Model ◽  
Surgical Intervention ◽  
Nerve Repair ◽  
Learning Curves ◽  
Rat Sciatic Nerve ◽  
Nerve Surgery

The baseline for any key research in nerve regeneration is an experimental model and the sciatic nerve in the rat model is the workhorse in this field. Although physically resistant to external traumas, a surgical intervention constitutes a major distress even for a rat. In the following presentation, we will analyse the learning curves for different stages in the rat sciatic nerve surgery as well as possible factors which influence these times.

scholarly journals Gellan Gum-based luminal fillers for peripheral nerve regeneration: an in vivo study in the rat sciatic nerve repair model

2018 ◽  
Vol 6 (5) ◽  
pp. 1059-1075 ◽  
Author(s):  
C. R. Carvalho ◽  
S. Wrobel ◽  
C. Meyer ◽  
C. Brandenberger ◽  
I. F. Cengiz ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Experimental Work ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Gellan Gum ◽  
In Vivo Study ◽  
Rat Sciatic Nerve

This experimental work considers the innovative use of the biomaterial Gellan Gum (GG) as a luminal filler for nerve guidance channels.

scholarly journals Mesenchymal Stem Cells Enhance Nerve Regeneration in a Rat Sciatic Nerve Repair and Hindlimb Transplant Model

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Damon S. Cooney ◽  
Eric G. Wimmers ◽  
Zuhaib Ibrahim ◽  
Johanna Grahammer ◽  
Joani M. Christensen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Rat Sciatic Nerve ◽  
Transplant Model

Effects of delayed nerve repair on regeneration of rat sciatic nerve

1995 ◽  
Vol 9 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Tadahisa Urabe ◽  
Qing Zhao ◽  
Göran Lundborg ◽  
Nils Danielsen
Keyword(s):  
Sciatic Nerve ◽  
Nerve Repair ◽  
Rat Sciatic Nerve

Cytochemistry and morphometry of rat sciatic nerve following laser and suture treatments

1986 ◽  
Vol 44 ◽  
pp. 128-129
Author(s):  
A. Shah ◽  
J. E. Bailes ◽  
V. Sahgal ◽  
L. J. Cerullo
Keyword(s):  
Sciatic Nerve ◽  
Horseradish Peroxidase ◽  
Light Microscopy ◽  
Morphological Study ◽  
Wallerian Degeneration ◽  
Nerve Repair ◽  
Nerve Fibers ◽  
Relative Efficacy ◽  
Tracer Technique ◽  
Rat Sciatic Nerve

The success of nerve repair treatment can be measured by examining the factors (Wallerian degeneration) that prevent functional recovery, and determining the extent of regeneration of proximal axon sprouts in the endoneurial environment of the distal fascicles. In the present study, the neurosurgical alignment of fascicles was attempted by laser as well as suture microsurgery of transected rat sciatic nerve and the relative efficacy of the two procedures was evaluated after 6 and 12 weeks by Neurophysiological Study, Morphological Study with light microscopy, ultrastructure, and the permeability of blood-nerve barrier using horseradish peroxidase (HRP) tracer technique, and Morphometry of the nerve fibers.

Specificity of Muscle Reinnervation following Repair of the Transected Sciatic Nerve

1992 ◽  
Vol 17 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Q. ZHAO ◽  
L. B. DAHLIN ◽  
M. KANJE ◽  
G. LUNDBORG
Keyword(s):  
Skeletal Muscle ◽  
Sciatic Nerve ◽  
Statistical Significance ◽  
Nerve Repair ◽  
Nerve Graft ◽  
The Other ◽  
Muscle Contractility ◽  
Tetanic Force ◽  
Rat Sciatic Nerve ◽  
Muscle Reinnervation

Specificity of muscle reinnervation and the recovery of muscle contractility were studied after repair of the transected rat sciatic nerve. Six different techniques were compared: epineurial suture, perineural suture, whole nerve graft, interfascicular grafts, skeletal muscle bridge and tubulization. Muscle tetanic force and specificity of reinnervation were evaluated 12 weeks after nerve repair. Recovery of tetanic force was superior after repair with epineurial sutures. There was no statistical significance between the other methods in respect of tetanic force. The specificity of muscle reinnervation was best after tubulization, repair with interfascicular grafts and perineurial suture.

Inside-out vein graft and inside-out artery graft in rat sciatic nerve repair

Microsurgery ◽  
2003 ◽  
Vol 23 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Al�cio Santos Barcelos ◽  
Antonio Castro Rodrigues ◽  
Maeli Dal Pai Silva ◽  
Carlos R. Padovani
Keyword(s):  
Sciatic Nerve ◽  
Vein Graft ◽  
Nerve Repair ◽  
Rat Sciatic Nerve ◽  
Artery Graft ◽  
Inside Out

Detection of E-Cadherin Expression After Nerve Repair in a Rat Sciatic Nerve Model

2001 ◽  
Vol 47 (2) ◽  
pp. 178-182 ◽  
Author(s):  
Hideyuki Tada ◽  
Mitsuo Hatoko ◽  
Aya Tanaka ◽  
Masamitsu Kuwahara ◽  
Kumi Mashiba ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Nerve Repair ◽  
Rat Sciatic Nerve ◽  
Nerve Model ◽  
E Cadherin
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