scholarly journals Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: A [I-123]FP-CIT SPECT study

2010 ◽  
Vol 25 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Flavio Nobili ◽  
Claudio Campus ◽  
Dario Arnaldi ◽  
Fabrizio De Carli ◽  
Gaia Cabassi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
De Novo ◽  
Drug Naïve

The single intake of levodopa modulates implicit learning in drug naïve, de novo patients with idiopathic Parkinson’s disease

2016 ◽  
Vol 123 (6) ◽  
pp. 601-610 ◽  
Author(s):  
Sarah Geffe ◽  
Katharina A. Schindlbeck ◽  
Arne Mehl ◽  
Johann Jende ◽  
Fabian Klostermann ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Implicit Learning ◽  
De Novo ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease ◽  
Drug Naïve

scholarly journals Stereopsis in Drug Naïve Parkinson's Disease Patients

2011 ◽  
Vol 38 (2) ◽  
pp. 299-302 ◽  
Author(s):  
Seung-Hyun Kim ◽  
Ji-Hye Park ◽  
Yu Hwan Kim ◽  
Seong-Beom Koh
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Visual Perception ◽  
Rating Scale ◽  
De Novo ◽  
Motor Deficits ◽  
Disease Rating ◽  
Drug Naïve ◽  
The Relationship ◽  
Abnormal Visual

Background:Motor deficits associated with Parkinson's disease (PD) have been well described, yet little attention has been paid to non-motor symptoms, especially cortical visual dysfunction. We investigated stereopsis, as well as the relationship between stereopsis and other cognitive function, in a sample of PD patients.Methods:We used Titmus stereotest plates for assessing stereopsis. Fifty-nine subjects (29 PD patients and 30 normal controls) were included in this study. The included patients underwent a neurological examination, clinical rating scale and neuropsychological tests.Results:Drug naïve PD patients showed decreased stereopsis on the Titmus fly stereopsis test (Pearson χ2=23.80, p<0.001) compared to PD patients with normal stereopsis. The Hoehn-Yahr stages and Unified Parkinson's Disease Rating Scale motor scores were significantly higher in patients with PD with abnormal stereopsis than in patients with PD with normal stereopsis (p=0.026; p=0.046). The frequency of abnormal visual perception/constructive function was greater in patients with PD with abnormal stereopsis compared to patients with PD with normal stereopsis (Pearson χ2=5.11, p=0.024).Conclusion:These findings suggest that stereopsis deficits and visual perception/constructive dysfunction are common in de novo PD patients.

scholarly journals Characterizing white matter alterations in drug-naïve de novo Parkinson’s disease with diffusion MRI

2021 ◽  
Author(s):  
Yiming Xiao ◽  
Terry M. Peters ◽  
Ali R. Khan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
De Novo ◽  
Neurodegenerative Disorder ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Motor Dysfunction ◽  
White Matter Integrity ◽  
Drug Naïve

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by a range of motor and non-motor symptoms, often with the motor dysfunction initiated unilaterally. Knowledge regarding disease-related alterations in white matter pathways can effectively help improve the understanding of the disease and propose targeted treatment strategies. Microstructural imaging techniques, including diffusion tensor imaging (DTI), allows inspection of white matter integrity to study the pathogenesis of various neurological conditions. Previous voxel-based analyses with DTI measures, such as fractional anisotropy and mean diffusivity have uncovered changes in brain regions that are associated with PD, but the conclusions were inconsistent, partially due to small patient cohorts and the lack of consideration for clinical laterality onset, particularly in early PD. Fixel-based analysis (FBA) is a recent framework that offers tract-specific insights regarding white matter health, but very few FBA studies on PD exist. We present a study that reveals strengthened and weakened white matter integrity that is subject to symptom laterality in a large drug-naïve de novo PD cohort using complementary DTI and FBA measures. The findings suggest that the disease gives rise to both functional degeneration and the creation of compensatory networks in the early stage.

scholarly journals Polysomnographic correlates of sleep disturbances in de novo, drug naïve Parkinson’s Disease

2021 ◽  
Author(s):  
Beatrice Orso ◽  
Francesco Famà ◽  
Laura Giorgetti ◽  
Pietro Mattioli ◽  
Andrea Donniaquio ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disturbances ◽  
De Novo ◽  
Sleep Onset ◽  
Inverse Correlation ◽  
Motor Symptoms ◽  
Periodic Leg Movements ◽  
Drug Naïve ◽  
Non Motor Symptoms

Abstract Background Sleep disturbances are common non-motor symptoms of Parkinson’s Disease (PD). Methods The aim of this study was to investigate the polysomnographic correlates of sleep changes, as investigated by the Parkinson’s Disease Sleep Scale-2 (PDSS-2), in a cohort of sixty-two consecutive de novo, drug naïve PD patients (71.40 ± 7.84 y/o). Results PDSS-2 total score showed a direct correlation with stage shifts (p = 0.008). Fragmented sleep showed an inverse correlation with sleep efficiency (p = 0.012). Insomnia symptoms showed an inverse correlation with wake after sleep onset (p = 0.005) and direct correlation with periodic leg movements (p = 0.006) and stage shift indices (p = 0.003). Motor Symptoms showed a direct correlation with Apnoea-Hypopnoea (AHI; p = 0.02) and awakenings indices (p = 0.003). Dream distressing showed a direct correlation with REM without atonia (RWA, p = 0.042) and an inverse correlation with AHI (p = 0.012). Sleep quality showed an inverse correlation with RWA (p = 0.008). Conclusion PDSS-2 features are significantly correlated with polysomnography objective findings, thus further supporting its reliability to investigate sleep disturbances in PD patients.

scholarly journals Restless Legs Syndrome and Leg Motor Restlessness in Parkinson’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Keisuke Suzuki ◽  
Masayuki Miyamoto ◽  
Tomoyuki Miyamoto ◽  
Koichi Hirata
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Restless Legs Syndrome ◽  
Sleep Disturbances ◽  
De Novo ◽  
Negative Impact ◽  
Restless Legs ◽  
Wearing Off ◽  
Drug Naïve ◽  
Motor Restlessness

Sleep disturbances are important nonmotor symptoms in Parkinson’s disease (PD) that are associated with a negative impact on quality of life. Restless legs syndrome (RLS), which is characterized by an urge to move the legs accompanied by abnormal leg sensations, can coexist with PD, although the pathophysiology of these disorders appears to be different. RLS and PD both respond favorably to dopaminergic treatment, and several investigators have reported a significant relationship between RLS and PD. Sensory symptoms, pain, motor restlessness, akathisia, and the wearing-off phenomenon observed in PD should be differentiated from RLS. RLS in PD may be confounded by chronic dopaminergic treatment; thus, more studies are needed to investigate RLS in drug-naïve patients with PD. Recently, leg motor restlessness (LMR), which is characterized by an urge to move the legs that does not fulfill the diagnostic criteria for RLS, has been reported to be observed more frequently in de novo patients with PD than in age-matched healthy controls, suggesting that LMR may be a part of sensorimotor symptoms intrinsic to PD. In this paper, we provide an overview of RLS, LMR, and PD and of the relationships among these disorders.

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