Intervening Effects of Orthostatic Blood Pressure Change on Subcortical Atrophy and Cognition in De Novo and Drug-Naïve Parkinson’s Disease

2020 ◽  
Vol 10 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Sang-Won Yoo ◽  
Yoon-Sang Oh ◽  
Ji-Yeon Yoo ◽  
Dong-Woo Ryu ◽  
Kwang-Soo Lee ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
De Novo ◽  
Pressure Change ◽  
Blood Pressure Change ◽  
Orthostatic Blood Pressure ◽  
Drug Naïve

The single intake of levodopa modulates implicit learning in drug naïve, de novo patients with idiopathic Parkinson’s disease

2016 ◽  
Vol 123 (6) ◽  
pp. 601-610 ◽  
Author(s):  
Sarah Geffe ◽  
Katharina A. Schindlbeck ◽  
Arne Mehl ◽  
Johann Jende ◽  
Fabian Klostermann ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Implicit Learning ◽  
De Novo ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease ◽  
Drug Naïve

scholarly journals Stereopsis in Drug Naïve Parkinson's Disease Patients

2011 ◽  
Vol 38 (2) ◽  
pp. 299-302 ◽  
Author(s):  
Seung-Hyun Kim ◽  
Ji-Hye Park ◽  
Yu Hwan Kim ◽  
Seong-Beom Koh
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Visual Perception ◽  
Rating Scale ◽  
De Novo ◽  
Motor Deficits ◽  
Disease Rating ◽  
Drug Naïve ◽  
The Relationship ◽  
Abnormal Visual

Background:Motor deficits associated with Parkinson's disease (PD) have been well described, yet little attention has been paid to non-motor symptoms, especially cortical visual dysfunction. We investigated stereopsis, as well as the relationship between stereopsis and other cognitive function, in a sample of PD patients.Methods:We used Titmus stereotest plates for assessing stereopsis. Fifty-nine subjects (29 PD patients and 30 normal controls) were included in this study. The included patients underwent a neurological examination, clinical rating scale and neuropsychological tests.Results:Drug naïve PD patients showed decreased stereopsis on the Titmus fly stereopsis test (Pearson χ2=23.80, p<0.001) compared to PD patients with normal stereopsis. The Hoehn-Yahr stages and Unified Parkinson's Disease Rating Scale motor scores were significantly higher in patients with PD with abnormal stereopsis than in patients with PD with normal stereopsis (p=0.026; p=0.046). The frequency of abnormal visual perception/constructive function was greater in patients with PD with abnormal stereopsis compared to patients with PD with normal stereopsis (Pearson χ2=5.11, p=0.024).Conclusion:These findings suggest that stereopsis deficits and visual perception/constructive dysfunction are common in de novo PD patients.

Effect of time standing up on orthostatic blood pressure change in the elderly: The J-SHIPP Study

2005 ◽  
Vol 5 (4) ◽  
pp. 254-258 ◽  
Author(s):  
Yasuharu Tabara ◽  
Katsuhiko Kohara ◽  
Toshie Azechi ◽  
Michie Ohnishi ◽  
Shouzoh Ueki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pressure Change ◽  
The Elderly ◽  
Blood Pressure Change ◽  
Orthostatic Blood Pressure ◽  
Standing Up

scholarly journals Characterizing white matter alterations in drug-naïve de novo Parkinson’s disease with diffusion MRI

2021 ◽  
Author(s):  
Yiming Xiao ◽  
Terry M. Peters ◽  
Ali R. Khan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
De Novo ◽  
Neurodegenerative Disorder ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Motor Dysfunction ◽  
White Matter Integrity ◽  
Drug Naïve

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by a range of motor and non-motor symptoms, often with the motor dysfunction initiated unilaterally. Knowledge regarding disease-related alterations in white matter pathways can effectively help improve the understanding of the disease and propose targeted treatment strategies. Microstructural imaging techniques, including diffusion tensor imaging (DTI), allows inspection of white matter integrity to study the pathogenesis of various neurological conditions. Previous voxel-based analyses with DTI measures, such as fractional anisotropy and mean diffusivity have uncovered changes in brain regions that are associated with PD, but the conclusions were inconsistent, partially due to small patient cohorts and the lack of consideration for clinical laterality onset, particularly in early PD. Fixel-based analysis (FBA) is a recent framework that offers tract-specific insights regarding white matter health, but very few FBA studies on PD exist. We present a study that reveals strengthened and weakened white matter integrity that is subject to symptom laterality in a large drug-naïve de novo PD cohort using complementary DTI and FBA measures. The findings suggest that the disease gives rise to both functional degeneration and the creation of compensatory networks in the early stage.

scholarly journals Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson’s disease and de novo dementia with Lewy bodies

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hisayoshi Oka ◽  
Tadashi Umehara ◽  
Atsuo Nakahara ◽  
Hiromasa Matsuno
Keyword(s):  
Blood Pressure ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Lewy Body ◽  
Dementia With Lewy Bodies ◽  
De Novo ◽  
Blood Pressure Monitoring ◽  
Lewy Bodies ◽  
Executive Dysfunction

Abstract Background Cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (BP) dysregulation, in Parkinson’s disease (PD), but the association between these factors in dementia with Lewy bodies (DLB) is uncertain. This study aimed to clarify whether cardiovascular dysautonomia had an influence on cognitive function in Lewy body disease or not. Methods Ninty-nine patients with de novo PD (n = 75) and DLB (n = 24) were evaluated using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). Cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy, orthostatic hypotension (OH), supine hypertension (SH), postprandial hypotension (PPH), nocturnal BP fall in 24-h ambulatory blood pressure monitoring (ABPM) and constipation were estimated. Associations of these factors with cognitive and executive dysfunction were examined. Results In DLB, MIBG uptake was reduced and OH, PPH and SH were severely disturbed, compared to PD. The nocturnal BP fall in ABPM was lower in DLB, and the failure of nocturnal BP fall in PD was associated with MMSE, after adjustment for other clinical features. FAB was significantly associated nocturnal BP fall, age and SH in PD, but no significant correlations among factors were found for DLB. Conclusion The significant association between nocturnal BP dysregulation and cognitive or executive decline in PD might be due to impaired microvascular circulation or invasion of α-synuclein in the CNS. The lack of a correlation of BP insufficiency with cognitive impairment in DLB suggests initial involvement of Lewy body pathology in the neocortex, regardless of Lewy body invasion of the autonomic nervous system.

scholarly journals Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: A [I-123]FP-CIT SPECT study

2010 ◽  
Vol 25 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Flavio Nobili ◽  
Claudio Campus ◽  
Dario Arnaldi ◽  
Fabrizio De Carli ◽  
Gaia Cabassi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
De Novo ◽  
Drug Naïve

scholarly journals The Orthostatic Blood Pressure Change and Its Influence Factors in Young Students

2012 ◽  
Vol 25 (3) ◽  
pp. 396-396
Author(s):  
Qing-yi Zeng ◽  
Zhi-qiang Wang ◽  
Da Huang ◽  
An Zhou ◽  
Xiang Tu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Influence Factors ◽  
Pressure Change ◽  
Blood Pressure Change ◽  
Orthostatic Blood Pressure ◽  
Young Students
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