Downregulation of HDPR1 is associated with poor prognosis and affects expression levels of p120-catenin and β-catenin in nonsmall cell lung cancer

2010 ◽  
Vol 49 (5) ◽  
pp. 508-519 ◽  
Author(s):  
Zhi-Qiang Yang ◽  
Yue Zhao ◽  
Yang Liu ◽  
Jun-Yi Zhang ◽  
Sheng Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Nonsmall Cell Lung Cancer ◽  
P120 Catenin ◽  
Expression Levels

scholarly journals Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis

2016 ◽  
Vol 47 (4) ◽  
pp. 1277-1280 ◽  
Author(s):  
Antoine Guillon ◽  
Fabien Gueugnon ◽  
Konstantinos Mavridis ◽  
Emilie Dalloneau ◽  
Youenn Jouan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Nonsmall Cell Lung Cancer ◽  
Interleukin 22

Downregulation of Kruppel-like factor 2 is associated with poor prognosis for nonsmall-cell lung cancer

Tumor Biology ◽  
2014 ◽  
Vol 36 (4) ◽  
pp. 3075-3084 ◽  
Author(s):  
Li Yin ◽  
Ji-peng Wang ◽  
Tong-peng Xu ◽  
Wen-ming Chen ◽  
Ming-de Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Nonsmall Cell Lung Cancer

scholarly journals Gene Expression Levels of the Prolyl Hydroxylase Domain Proteins PHD1 and PHD2 but Not PHD3 Are Decreased in Primary Tumours and Correlate with Poor Prognosis of Patients with Surgically Resected Non-Small-Cell Lung Cancer

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2309
Author(s):  
Ana Koren ◽  
Matija Rijavec ◽  
Tomaž Krumpestar ◽  
Izidor Kern ◽  
Aleksander Sadikov ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Small Cell ◽  
Prolyl Hydroxylase ◽  
Small Cell Lung ◽  
Expression Levels ◽  
Hif Pathway ◽  
Normal Lungs

Background: Hypoxia correlates with poor prognosis in several cancer types, including lung cancer. Prolyl hydroxylase domain proteins (PHDs) play a role in cell oxygen sensing, negatively regulating the hypoxia-inducible factor (HIF) pathway. Our study aim was to evaluate PHD1, PHD2 and PHD3 mRNA expression levels in primary tumours and normal lungs of non-small-cell lung cancer (NSCLC) patients and to correlate it with selected regulators of HIF signalling, with clinicopathological characteristics and overall survival (OS). Methods: Tumour tissue samples were obtained from 60 patients with surgically resected NSCLC who were treated with radical surgery. In 22 out of 60 cases, matching morphologically normal lung tissue was obtained. PHD1, PHD2 and PHD3 mRNA expressions were measured using RT-qPCR. Results: The PHD1 and PHD2 mRNA levels in primary tumours were significantly decreased compared to those in normal lungs (both p < 0.0001). PHD1 and PHD2 expression in tumours was positively correlated (rs = 0.82; p < 0.0001) and correlated well with HIF pathway downstream genes HIF1A, PKM2 and PDK1. Decreased PHD1 and PHD2 were associated with larger tumour size, higher tumour stage (PHD1 only) and squamous cell carcinoma. Patients with low PHD1 and patients with low PHD2 expression had shorter OS than patients with high PHD1 (p = 0.02) and PHD2 expression (p = 0.01). PHD1 showed borderline independent prognostic values in multivariate analysis (p = 0.06). In contrast, we found no associations between PHD3 expression and any of the observed parameters. Conclusions: Our results show that reduced expression of PHD1 and PHD2 is associated with the development and progression of NSCLC. PHD1 could be further assessed as a prognostic marker in NSCLC.

scholarly journals CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer

Cancer ◽  
2010 ◽  
Vol 116 (15) ◽  
pp. 3645-3655 ◽  
Author(s):  
Mauro Antonio Alves Castro ◽  
Felipe Dal-Pizzol ◽  
Stephanie Zdanov ◽  
Marcio Soares ◽  
Carolina Beatriz Müller ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Resistance Marker ◽  
Expression Levels ◽  
Drug Resistance Marker

Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer

2010 ◽  
Vol 49 (10) ◽  
pp. 874-881 ◽  
Author(s):  
Po-Len Liu ◽  
Jong-Rung Tsai ◽  
Chien-Chih Chiu ◽  
Jhi-Jhu Hwang ◽  
Shah-Hwa Chou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Nonsmall Cell Lung Cancer ◽  
Cell Invasiveness
Sign in / Sign up

Export Citation Format

Share Document