Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer

2010 ◽  
Vol 49 (10) ◽  
pp. 874-881 ◽  
Author(s):  
Po-Len Liu ◽  
Jong-Rung Tsai ◽  
Chien-Chih Chiu ◽  
Jhi-Jhu Hwang ◽  
Shah-Hwa Chou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Nonsmall Cell Lung Cancer ◽  
Cell Invasiveness

Abstract 3070: Suppression of tumor cell invasiveness andin vivotumor growth by microRNA-874 in non-small cell lung cancer.

2013 ◽  
Author(s):  
Divya Kesanakurti ◽  
Dilip Maddirela ◽  
Subramanyam Chittivelu ◽  
Jasti S. Rao ◽  
Chandramu Chetty
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Invasiveness

scholarly journals Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis

2016 ◽  
Vol 47 (4) ◽  
pp. 1277-1280 ◽  
Author(s):  
Antoine Guillon ◽  
Fabien Gueugnon ◽  
Konstantinos Mavridis ◽  
Emilie Dalloneau ◽  
Youenn Jouan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Nonsmall Cell Lung Cancer ◽  
Interleukin 22

scholarly journals MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

2017 ◽  
Vol 42 (1) ◽  
pp. 346-356 ◽  
Author(s):  
Yang Cao ◽  
Dan Zhao ◽  
Ping Li ◽  
Lanrong Wang ◽  
Bingli Qiao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Interleukin 17 ◽  
Tumor Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

Aim: The contribution of the inflammatory mediator interleukin-17 (IL-17) in nonsmall cell lung cancer (NSCLC) malignancy has been reported in the literature. MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level. Our study aimed to investigate the interaction between IL-17 and miR-181a-5p in NSCLC. Methods: 35 patients with NSCLC and 24 COPD controls were selected and examined in our study. In vitro, H226 and H460 cell lines were exposed to different doses (20, 40, 60, and 80 ng/mL) of IL-17 to examine the effect of IL-17 on miR-181a-5p and vascular cell adhesion molecule 1 (VCAM-1) expression. MiR-181 mimic and miR-181a-5p inhibitor were transfected to explore the regulation of VCAM-1 as well as tumor cell proliferation and migration. Results: miR-181a-5p expression was downregulated, and IL-17 and VCAM-1 expression was upregulated in NSCLC tissues. Furthermore, IL-17 decreased miR-181a-5p expression but increased VCAM-1 expression in H226 and H460 cells. MiR-181 regulated VCAM-1 expression through binding to 3’-UTR sequence. MiR-181 attenuated tumor cell proliferation and migration. IL-17 modulated miR-181a-5p expression through activating NF-κB but not Stat3. Conclusion: Taken together, our data show the regulation of VCAM-1 expression by miR-181a-5p under IL-17 exposure, predicting a potential way for counteracting cancer metastasis.

Downregulation of Kruppel-like factor 2 is associated with poor prognosis for nonsmall-cell lung cancer

Tumor Biology ◽  
2014 ◽  
Vol 36 (4) ◽  
pp. 3075-3084 ◽  
Author(s):  
Li Yin ◽  
Ji-peng Wang ◽  
Tong-peng Xu ◽  
Wen-ming Chen ◽  
Ming-de Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Nonsmall Cell Lung Cancer

scholarly journals Human Kallikrein 8 Protease Confers a Favorable Clinical Outcome in Non–Small Cell Lung Cancer by Suppressing Tumor Cell Invasiveness

2006 ◽  
Vol 66 (24) ◽  
pp. 11763-11770 ◽  
Author(s):  
Yuh-Pyng Sher ◽  
Cheng-Chung Chou ◽  
Ruey-Hwang Chou ◽  
Han-Ming Wu ◽  
Wun-Shaing Wayne Chang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Outcome ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Favorable Clinical Outcome ◽  
Cell Invasiveness

scholarly journals Suppression of tumor cell invasiveness and in vivo tumor growth by microRNA-874 in non-small cell lung cancer

2013 ◽  
Vol 434 (3) ◽  
pp. 627-633 ◽  
Author(s):  
Divya Kesanakurti ◽  
Dilip Rajasekhar Maddirela ◽  
Subramanyam Chittivelu ◽  
Jasti S. Rao ◽  
Chandramu Chetty
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Invasiveness
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