Protected, Concerted Activity in the Nonunion Workplace

Early co-transcriptional events of eukaryotic ribosome assembly result in the formation of the small and large subunit processomes. We have determined cryo-EM reconstructions of the nucleolar large subunit processome in different conformational states at resolutions up to 3.4 Ångstroms. These structures reveal how steric hindrance and molecular mimicry are used to prevent premature folding states and binding of later factors. This is accomplished by the concerted activity of 21 ribosome assembly factors that stabilize and remodel pre-ribosomal RNA and ribosomal proteins. Mutually exclusive conformations of these particles suggest that the formation of the polypeptide exit tunnel is achieved through different folding pathways during subsequent stages of ribosome assembly.

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Protected Concerted Activity and Non-Unionized Employee Strikes: Worker Rights in Canada in the Time of COVID-19

SSRN Electronic Journal ◽

10.2139/ssrn.3700582 ◽

2020 ◽

Author(s):

Sara Slinn

Keyword(s):

Worker Rights ◽

Concerted Activity

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Genome-scale Co-occurrence and Co-transcription Networks Reveal Key Microbial Taxa in Mangrove Sediments

10.21203/rs.3.rs-41034/v1 ◽

2020 ◽

Author(s):

Yang Liu ◽

Zhichao Zhou ◽

Yuchun Yang ◽

Meng Li

Keyword(s):

Sulfate Reduction ◽

Mangrove Ecosystem ◽

Mangrove Sediment ◽

Dissimilatory Sulfate Reduction ◽

Element Cycling ◽

Transcription Network ◽

Concerted Activity ◽

Ecological Importance ◽

Transcription Networks ◽

Genome Scale

Abstract BackgroundMangroves are highly productive ecosystems, with one of the highest microbial diversities among all ecosystems. The concerted activity of microbial community in mangrove sediment mediates element cycling, but the underpinning mechanism of microbial synergy remains unknown. ResultsHere, we reconstructed 671 strain-resolved metagenome-assembled genomes (MAGs) from three mangrove and two mudflat sediments in Mai Po Nature Reserve. We then inferred the genome-scale co-occurrence and co-transcription networks based on metabolic capacity and transcriptional activity of the carbon, nitrogen, and sulfur cycles. We observed that the centrality was significantly higher in co-transcription networks than in co-occurrence networks, indicating that MAGs had stronger interrelationships when transcriptionally active. Further, we classified 57 microbes with low relative abundance (0.01–0.79%) as keystone taxa, which play key roles in the maintenance of co-transcription network structure, and participate in carbon transformations, denitrification, and sulfate reduction processes. One of the keystone taxa is a newly proposed deltaproteobacterial order, Candidatus Mangrovidesulfobacterales, capable of dissimilatory sulfate reduction and an anaerobic mixotrophic lifestyle. These findings highlight the ecological importance of rare species. ConclusionsCollectively, this first screening of the potential keystone taxa in mangrove ecosystem based on genome-scale transcriptomic analysis revealed unique microbial functional assemblages, shedding light on microbial synergism in this ecosystem.

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‘Green podiatry’ - reducing our carbon footprints. Lessons from a sustainability panel

Journal of Foot and Ankle Research ◽

10.1186/s13047-021-00497-1 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Angela Margaret Evans

Keyword(s):

Climate Change ◽

Human Health ◽

Evidence Based ◽

Main Body ◽

Weather Extremes ◽

Ethical Considerations ◽

Carbon Footprints ◽

Change Communication ◽

Net Zero ◽

Concerted Activity

Abstract Background The eyes of the world will be on COP26 as it meets in Glasgow in November, 2021. Our planet is displaying weather extremes due to climate change which cannot be ignored, and which are deleterious for people’s health. Ironically, healthcare contributes to climate change, contributing approximately 5% of carbon emissions globally. Climate change due to global warming is ‘the biggest global health threat of the 21st century’. Main body The Australian Podiatry Association conference held a sustainability panel, hearing perspectives of industry and science, medicine and sport, fashion, and retail. Content unified a broad planet and human health message, which is highly relevant for podiatrists. Key themes included waste as a resource, exercise as evidence-based intervention, responsibility and circular economy recycling principles for end-of-life product (footwear) purchases, and wider ethical considerations of footwear and clothing. The Anthropocene origin of climate change requires humanity to collaborate and to live more sustainably. Innovation is essential for better energy modes, cleaner air, human health and earth care. Green Podiatry joins the concerted activity of medical and health groups within Australia. The UK’s NHS is an exemplar in this area, having already reduced healthcare emissions by 35%, and aiming for net zero by 2045, and perhaps sooner. Conclusion People are increasingly concerned about climate change, and COP26 is an important and imminent meeting for human and planet health. This commentary on Green Podiatry directs us all to lighten our carbon footprint. A final, and forthcoming commentary will outline practical ways of positively incorporating climate change communication into the clinical setting.

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