An Employee Who Lies May Still Be Engaged in Protected Concerted Activity

2015 ◽  
Vol 38 (11) ◽  
pp. 6-7
Keyword(s):  
Concerted Activity

scholarly journals Modular assembly of the nucleolar large subunit processome

2017 ◽  
Author(s):  
Zahra Assur Sanghai ◽  
Linamarie Miller ◽  
Kelly R. Molloy ◽  
Jonas Barandun ◽  
Mirjam Hunziker ◽  
...  
Keyword(s):  
Ribosomal Rna ◽  
Ribosomal Proteins ◽  
Molecular Mimicry ◽  
Large Subunit ◽  
Ribosome Assembly ◽  
Modular Assembly ◽  
Assembly Result ◽  
Concerted Activity ◽  
Folding Pathways ◽  
Exit Tunnel

Early co-transcriptional events of eukaryotic ribosome assembly result in the formation of the small and large subunit processomes. We have determined cryo-EM reconstructions of the nucleolar large subunit processome in different conformational states at resolutions up to 3.4 Ångstroms. These structures reveal how steric hindrance and molecular mimicry are used to prevent premature folding states and binding of later factors. This is accomplished by the concerted activity of 21 ribosome assembly factors that stabilize and remodel pre-ribosomal RNA and ribosomal proteins. Mutually exclusive conformations of these particles suggest that the formation of the polypeptide exit tunnel is achieved through different folding pathways during subsequent stages of ribosome assembly.

scholarly journals Genome-scale Co-occurrence and Co-transcription Networks Reveal Key Microbial Taxa in Mangrove Sediments

2020 ◽  
Author(s):  
Yang Liu ◽  
Zhichao Zhou ◽  
Yuchun Yang ◽  
Meng Li
Keyword(s):  
Sulfate Reduction ◽  
Mangrove Ecosystem ◽  
Mangrove Sediment ◽  
Dissimilatory Sulfate Reduction ◽  
Element Cycling ◽  
Transcription Network ◽  
Concerted Activity ◽  
Ecological Importance ◽  
Transcription Networks ◽  
Genome Scale

Abstract BackgroundMangroves are highly productive ecosystems, with one of the highest microbial diversities among all ecosystems. The concerted activity of microbial community in mangrove sediment mediates element cycling, but the underpinning mechanism of microbial synergy remains unknown. ResultsHere, we reconstructed 671 strain-resolved metagenome-assembled genomes (MAGs) from three mangrove and two mudflat sediments in Mai Po Nature Reserve. We then inferred the genome-scale co-occurrence and co-transcription networks based on metabolic capacity and transcriptional activity of the carbon, nitrogen, and sulfur cycles. We observed that the centrality was significantly higher in co-transcription networks than in co-occurrence networks, indicating that MAGs had stronger interrelationships when transcriptionally active. Further, we classified 57 microbes with low relative abundance (0.01–0.79%) as keystone taxa, which play key roles in the maintenance of co-transcription network structure, and participate in carbon transformations, denitrification, and sulfate reduction processes. One of the keystone taxa is a newly proposed deltaproteobacterial order, Candidatus Mangrovidesulfobacterales, capable of dissimilatory sulfate reduction and an anaerobic mixotrophic lifestyle. These findings highlight the ecological importance of rare species. ConclusionsCollectively, this first screening of the potential keystone taxa in mangrove ecosystem based on genome-scale transcriptomic analysis revealed unique microbial functional assemblages, shedding light on microbial synergism in this ecosystem.

scholarly journals ‘Green podiatry’ - reducing our carbon footprints. Lessons from a sustainability panel

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Angela Margaret Evans
Keyword(s):  
Climate Change ◽  
Human Health ◽  
Evidence Based ◽  
Main Body ◽  
Weather Extremes ◽  
Ethical Considerations ◽  
Carbon Footprints ◽  
Change Communication ◽  
Net Zero ◽  
Concerted Activity

Abstract Background The eyes of the world will be on COP26 as it meets in Glasgow in November, 2021. Our planet is displaying weather extremes due to climate change which cannot be ignored, and which are deleterious for people’s health. Ironically, healthcare contributes to climate change, contributing approximately 5% of carbon emissions globally. Climate change due to global warming is ‘the biggest global health threat of the 21st century’. Main body The Australian Podiatry Association conference held a sustainability panel, hearing perspectives of industry and science, medicine and sport, fashion, and retail. Content unified a broad planet and human health message, which is highly relevant for podiatrists. Key themes included waste as a resource, exercise as evidence-based intervention, responsibility and circular economy recycling principles for end-of-life product (footwear) purchases, and wider ethical considerations of footwear and clothing. The Anthropocene origin of climate change requires humanity to collaborate and to live more sustainably. Innovation is essential for better energy modes, cleaner air, human health and earth care. Green Podiatry joins the concerted activity of medical and health groups within Australia. The UK’s NHS is an exemplar in this area, having already reduced healthcare emissions by 35%, and aiming for net zero by 2045, and perhaps sooner. Conclusion People are increasingly concerned about climate change, and COP26 is an important and imminent meeting for human and planet health. This commentary on Green Podiatry directs us all to lighten our carbon footprint. A final, and forthcoming commentary will outline practical ways of positively incorporating climate change communication into the clinical setting.

scholarly journals A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

2020 ◽  
Author(s):  
Shankar Ramachandran ◽  
Navonil Banerjee ◽  
Raja Bhattacharya ◽  
Denis Touroutine ◽  
Christopher M. Lambert ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Adaptive Behavior ◽  
Environmental Conditions ◽  
Body Wall ◽  
Behavioral Responses ◽  
Physiological Changes ◽  
C Elegans ◽  
Motor Circuits ◽  
Concerted Activity ◽  
Stimulation Of

SUMMARYNeuromodulators promote adaptive behaviors in response to either environmental or internal physiological changes. These responses are often complex and may involve concerted activity changes across circuits that are not physically connected. It is not well understood how neuromodulatory systems act across circuits to elicit complex behavioral responses. Here we show that the C. elegans NLP-12 neuropeptide system shapes responses to food availability by selectively modulating the activity of head and body wall motor neurons. NLP-12 modulation of the head and body wall motor circuits is generated through conditional involvement of alternate GPCR targets. The CKR-1 GPCR is highly expressed in the head motor circuit, and functions to enhance head bending and increase trajectory reorientations during local food searching, primarily through stimulatory actions on SMD head motor neurons. In contrast, NLP-12 activation of CKR-1 and CKR-2 GPCRs regulates body bending under basal conditions, primarily through actions on body wall motor neurons. Thus, locomotor responses to changing environmental conditions emerge from conditional NLP-12 stimulation of head or body wall motor neuron targets.

Sign in / Sign up

Export Citation Format

Share Document