Synthesis of High Density Polymer Brushes on Nanoparticles by Combined RAFT Polymerization and Click Chemistry

2008 ◽  
Vol 29 (12–13) ◽  
pp. 1104-1110 ◽  
Author(s):  
Rajesh Ranjan ◽  
William J. Brittain
2011 ◽  
Vol 50 (2) ◽  
pp. 329-337 ◽  
Author(s):  
Yongfang Yang ◽  
Xiaohui Song ◽  
Liang Yuan ◽  
Mao Li ◽  
Jinchuan Liu ◽  
...  

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Wenbin Wei ◽  
Jessica L. Faubel ◽  
Hemaa Selvakumar ◽  
Daniel T. Kovari ◽  
Joanna Tsao ◽  
...  

AbstractTailoring interfaces with polymer brushes is a commonly used strategy to create functional materials for numerous applications. Existing methods are limited in brush thickness, the ability to generate high-density brushes of biopolymers, and the potential for regeneration. Here we introduce a scheme to synthesize ultra-thick regenerating hyaluronan polymer brushes using hyaluronan synthase. The platform provides a dynamic interface with tunable brush heights that extend up to 20 microns – two orders of magnitude thicker than standard brushes. The brushes are easily sculpted into micropatterned landscapes by photo-deactivation of the enzyme. Further, they provide a continuous source of megadalton hyaluronan or they can be covalently-stabilized to the surface. Stabilized brushes exhibit superb resistance to biofilms, yet are locally digested by fibroblasts. This brush technology provides opportunities in a range of arenas including regenerating tailorable biointerfaces for implants, wound healing or lubrication as well as fundamental studies of the glycocalyx and polymer physics.


Polymer ◽  
2012 ◽  
Vol 53 (10) ◽  
pp. 1992-2000 ◽  
Author(s):  
Peng Zhao ◽  
Yechao Yan ◽  
Xiaoqin Feng ◽  
Lixin Liu ◽  
Chun Wang ◽  
...  

2016 ◽  
Vol 7 (40) ◽  
pp. 6220-6230 ◽  
Author(s):  
Haiwang Lai ◽  
Mingxia Lu ◽  
Hongxu Lu ◽  
Martina H. Stenzel ◽  
Pu Xiao

Prodrug (gemcitabine)-based polymer coated nanodiamonds as stimuli-responsive drug delivery platforms for the treatment of pancreatic cancer.


2007 ◽  
Vol 40 (3) ◽  
pp. 474-481 ◽  
Author(s):  
Sudershan R. Gondi ◽  
Andrew P. Vogt ◽  
Brent S. Sumerlin

RSC Advances ◽  
2016 ◽  
Vol 6 (18) ◽  
pp. 14496-14504 ◽  
Author(s):  
Sofyane Andjouh ◽  
Christine Bressy ◽  
Yves Blache

A series of bromotyramine-based 4-acryloyl-1,2,3-triazole monomers and polymers using click chemistry and RAFT polymerization.


2003 ◽  
Vol 42 (24) ◽  
pp. 2751-2754 ◽  
Author(s):  
Kohji Ohno ◽  
Kyoungmoo Koh ◽  
Yoshinobu Tsujii ◽  
Takeshi Fukuda

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