Fabrication and Evaluation of Polycaprolactone-Poly(hydroxybutyrate) or Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Dual-Leached Porous Scaffolds for Bone Tissue Engineering Applications

2016 ◽  
Vol 302 (3) ◽  
pp. 1600289 ◽  
Author(s):  
Napaphat Thadavirul ◽  
Prasit Pavasant ◽  
Pitt Supaphol
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffolds ◽  
Engineering Applications

Fabrication of alumina porous scaffolds with aligned oriented pores for bone tissue engineering applications

2016 ◽  
Vol 122 (4) ◽  
Author(s):  
Fatemeh Sarhadi ◽  
Mahdi Shafiee Afarani ◽  
Davod Mohebbi-Kalhori ◽  
Masoud Shayesteh
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffolds ◽  
Engineering Applications

scholarly journals Antioxidant, and enhanced flexible nano porous scaffolds for bone tissue engineering applications

Nano Select ◽  
2021 ◽  
Author(s):  
Muhammad Sohail Asghar ◽  
Jinhua Li ◽  
Iftikhar Ahmed ◽  
Uzma Ghazanfar ◽  
Muhammad Sultan Irshad ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffolds ◽  
Engineering Applications

scholarly journals Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 590 ◽  
Author(s):  
Yuchao Li ◽  
Chengzhu Liao ◽  
Sie Chin Tjong
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cell Attachment ◽  
Porous Scaffolds ◽  
Aliphatic Polyester ◽  
Engineering Applications ◽  
Aliphatic Polyesters ◽  
Nanocomposite Scaffolds

This paper provides review updates on the current development of bionanocomposites with polymeric matrices consisting of synthetic biodegradable aliphatic polyesters reinforced with nanohydroxyaptite (nHA) and/or graphene oxide (GO) nanofillers for bone tissue engineering applications. Biodegradable aliphatic polyesters include poly(lactic acid) (PLA), polycaprolactone (PCL) and copolymers of PLA-PGA (PLGA). Those bionanocomposites have been explored for making 3D porous scaffolds for the repair of bone defects since nHA and GO enhance their bioactivity and biocompatibility by promoting biomineralization, bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. The incorporation of nHA or GO into aliphatic polyester scaffolds also improves their mechanical strength greatly, especially hybrid GO/nHA nanofilllers. Those mechanically strong nanocomposite scaffolds can support and promote cell attachment for tissue growth. Porous scaffolds fabricated from conventional porogen leaching, and thermally induced phase separation have many drawbacks inducing the use of organic solvents, poor control of pore shape and pore interconnectivity, while electrospinning mats exhibit small pores that limit cell infiltration and tissue ingrowth. Recent advancement of 3D additive manufacturing allows the production of aliphatic polyester nanocomposite scaffolds with precisely controlled pore geometries and large pores for the cell attachment, growth, and differentiation in vitro, and the new bone formation in vivo.

Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications

2011 ◽  
Vol 100B (2) ◽  
pp. 501-507 ◽  
Author(s):  
Natalia Higuita-Castro ◽  
Daniel Gallego-Perez ◽  
Alejandro Pelaez-Vargas ◽  
Felipe García Quiroz ◽  
Olga M. Posada ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Portland Cement ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffolds ◽  
Engineering Applications ◽  
Load Bearing

Exploration of gum ghatti-modified porous scaffolds for bone tissue engineering applications

2020 ◽  
Vol 44 (6) ◽  
pp. 2389-2401 ◽  
Author(s):  
J. Anita Lett ◽  
Suresh Sagadevan ◽  
Zohreh Shahnavaz ◽  
Muthiah Bavani Latha ◽  
Karthick Alagarswamy ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Porous Scaffolds ◽  
Engineering Applications ◽  
Gum Ghatti ◽  
Hydroxyl Apatite

Taking advantage of the tissue engineering principles, the formed hydroxyl apatite-modified gum ghatti biomaterial with its porous nature, biocompatibility, and efficient mechanical properties can be potential for the bone repair and regeneration.

scholarly journals Development of Biopolymeric Hybrid Scaffold-Based on AAc/GO/nHAp/TiO2 Nanocomposite for Bone Tissue Engineering: In-Vitro Analysis

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1319
Author(s):  
Muhammad Umar Aslam Khan ◽  
Wafa Shamsan Al-Arjan ◽  
Mona Saad Binkadem ◽  
Hassan Mehboob ◽  
Adnan Haider ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Guar Gum ◽  
Porous Scaffolds ◽  
Vitro Assay ◽  
Vitro Analysis ◽  
Nanocomposite Scaffolds

Bone tissue engineering is an advanced field for treatment of fractured bones to restore/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible characteristics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young’s modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 μm) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast (MC3T3-E1) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering.

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