Acid-Labile Copolymer Micelles Cross-Linked by a Twin Ortho Ester Cross-Linking Agent: Synthesis, Characterization, and Evaluation

2016 ◽  
Vol 217 (19) ◽  
pp. 2182-2190 ◽  
Author(s):  
Xin Wang ◽  
Xiaojing Zhou ◽  
Jun Wang ◽  
Zhipeng Cao ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Cross Linking ◽  
Ortho Ester ◽  
Copolymer Micelles ◽  
Acid Labile

Cross-Linking of Cationic Block Copolymer Micelles by Silica Deposition

2007 ◽  
Vol 129 (6) ◽  
pp. 1717-1723 ◽  
Author(s):  
Jian-Jun Yuan ◽  
Oleksandr O. Mykhaylyk ◽  
Anthony J. Ryan ◽  
Steven P. Armes
Keyword(s):  
Block Copolymer ◽  
Cross Linking ◽  
Silica Deposition ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Acid-labile poly(amino alcohol ortho ester) based on low molecular weight polyethyleneimine for gene delivery

2017 ◽  
Vol 32 (3) ◽  
pp. 349-361 ◽  
Author(s):  
Jun Wang ◽  
Lei Zhang ◽  
Xin Wang ◽  
Shengxiang Fu ◽  
Guoqing Yan
Keyword(s):  
Molecular Weight ◽  
Amino Alcohol ◽  
Water Solubility ◽  
Transfection Efficiency ◽  
Enzymatic Digestion ◽  
Low Molecular Weight ◽  
Hydroxyl Groups ◽  
Ortho Ester ◽  
Human Neuroblastoma ◽  
Acid Labile

A series of acid-labile poly(amino alcohol ortho ester) (POEeis) were synthesized through ring-opening polymerization between diglycidyl ethers with ortho ester bonded and low molecular weight polyethyleneimine by various feed molar ratios. The obtain POEei 1 and POEei 2 exhibited clear kinetic of degradation and condensed plasmid DNA into nanoparticles of suitable sizes (250–300 nm) and positive zeta potentials (+20–30 mV) while protecting DNA from enzymatic digestion. Further, these polymers have uniform distribution of abundant hydroxyl groups, which could improve their water solubility, biocompatibility, and lower protein adsorption. Significantly, ortho ester groups in POEeis main-chains could hydrolyze rapidly at acidic endosomal pH, resulting in intracellular DNA release and diminished material toxicity. MTT assay revealed that all the polymers exhibited much lower cytotoxicity than 25 kDa PEI in the human neuroblastoma SH-SY5Y cells. Moreover, the transfection efficiency of POEei 1 was higher than 25 kDa PEI in serum-free medium or 10% serum medium.

scholarly journals Poly(ortho ester amides): Acid-Labile Temperature-Responsive Copolymers for Potential Biomedical Applications

2009 ◽  
Vol 10 (4) ◽  
pp. 722-727 ◽  
Author(s):  
Rupei Tang ◽  
R. Noelle Palumbo ◽  
Weihang Ji ◽  
Chun Wang
Keyword(s):  
Biomedical Applications ◽  
Ortho Ester ◽  
Temperature Responsive ◽  
Acid Labile

PEGylated block copolymers containing tertiary amine side-chains cleavable via acid-labile ortho ester linkages for pH-triggered release of DNA

Polymer ◽  
2014 ◽  
Vol 55 (12) ◽  
pp. 2761-2771 ◽  
Author(s):  
Junping Lai ◽  
Zhangyan Xu ◽  
Rupei Tang ◽  
Weihang Ji ◽  
Rui Wang ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Tertiary Amine ◽  
Side Chains ◽  
Triggered Release ◽  
Ortho Ester ◽  
Acid Labile

Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform

2017 ◽  
Vol 46 (3) ◽  
pp. 569-585 ◽  
Author(s):  
Dechao Niu ◽  
Yongsheng Li ◽  
Jianlin Shi
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Hybrid Materials ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Amphiphilic Block Copolymers ◽  
Cross Linking ◽  
Design Synthesis ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Silica/organosilica cross-linked block copolymer micelles are a novel class of hybrid materials that combine the advantages of amphiphilic block copolymers and silica/organosilica cross-linking agents into one unit. This Tutorial Review summarizes the recent progress in the design, synthesis and biomedical applications of various silica/organosilica cross-linked block copolymer micelles.

Low Molecular Weight PEI-Based Vectors via Acid-Labile Ortho Ester Linkage for Improved Gene Delivery

2016 ◽  
Vol 16 (8) ◽  
pp. 1175-1187 ◽  
Author(s):  
Lei Zhang ◽  
Min Yu ◽  
Jun Wang ◽  
Rupei Tang ◽  
Guoqing Yan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
Ortho Ester ◽  
Ester Linkage ◽  
Acid Labile
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