Highly Flexible, Tough, and Self-Healable Hydrogels Enabled by Dual Cross-Linking of Triblock Copolymer Micelles and Ionic Interactions

2016 ◽  
Vol 302 (2) ◽  
pp. 1600352 ◽  
Author(s):  
Hongwei Zhou ◽  
Min Zhang ◽  
Jiancheng Cao ◽  
Bo Yan ◽  
Wen Yang ◽  
...  
Keyword(s):  
Triblock Copolymer ◽  
Ionic Interactions ◽  
Cross Linking ◽  
Copolymer Micelles

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

Acid-Labile Copolymer Micelles Cross-Linked by a Twin Ortho Ester Cross-Linking Agent: Synthesis, Characterization, and Evaluation

2016 ◽  
Vol 217 (19) ◽  
pp. 2182-2190 ◽  
Author(s):  
Xin Wang ◽  
Xiaojing Zhou ◽  
Jun Wang ◽  
Zhipeng Cao ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Cross Linking ◽  
Ortho Ester ◽  
Copolymer Micelles ◽  
Acid Labile

Stealth properties of poly(ethylene oxide)-based triblock copolymer micelles: A prerequisite for a pH-triggered targeting system

2011 ◽  
Vol 7 (10) ◽  
pp. 3700-3707 ◽  
Author(s):  
K. Van Butsele ◽  
M. Morille ◽  
C. Passirani ◽  
P. Legras ◽  
J.P. Benoit ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Triblock Copolymer ◽  
Poly Ethylene Oxide ◽  
Copolymer Micelles ◽  
Poly Ethylene

scholarly journals Triblock copolymer micelles as templates for preparation of mesoporous niobia thin films

2018 ◽  
Vol 992 ◽  
pp. 012037 ◽  
Author(s):  
R Georgiev ◽  
D Christova ◽  
L Todorova ◽  
B Georgieva ◽  
M Vasileva ◽  
...  
Keyword(s):  
Thin Films ◽  
Triblock Copolymer ◽  
Copolymer Micelles

THERMOREVERSIBLE CROSS-LINKING MALEIC ANHYDRIDE GRAFTED CHLOROBUTYL RUBBER WITH HYDROGEN BONDS (COMBINED WITH IONIC INTERACTIONS)

2014 ◽  
Vol 87 (3) ◽  
pp. 459-470 ◽  
Author(s):  
Lin Li ◽  
Jin Kuk Kim
Keyword(s):  
Hydrogen Bonds ◽  
Maleic Anhydride ◽  
Ionic Interactions ◽  
Cross Linking ◽  
External Energy ◽  
Scanning Calorimetry ◽  
Ionic Bonds ◽  
Cross Links ◽  
Ionic Hydrogen Bonds ◽  
Chlorobutyl Rubber

ABSTRACT Thermoreversible cross-linking polymers are designed based on reversible cross-linking bonds. These bonds are able to reversibly dissociate and associate upon the input of external energy, such as heat or light. Reprocessibility is possible for this kind of material. The objective was to thermoreversibly cross-link maleic anhydride grafted chlorobutyl rubber (MAH-g-CIIR) via a reaction with octadecylamine, with an excess to obtain amide-salts, which form both hydrogen bonds and ionic interactions. X-ray diffraction experiments showed the presence of microphase-separated aggregates that acted as physical cross-links for both the MAH-g-CIIR precursor and amide-salts. The tensile properties were improved by converting MAH-g-CIIR to amide-salts, because of the combination of hydrogen bonding and ionic interactions. The cross-linked materials could be repeatedly compression molded at 155 °C into homogeneous films. The differential scanning calorimetry curves and Fourier transform infrared spectra indicate that hydrogen bonds are of a thermoreversible nature, but the recovery of ionic bonds is impossible. After treatment with heating-cooling for up to three cycles, the tensile strength of the thermoreversible cross-linking CIIR was greatly reduced. The gradual reduction in the effectiveness of the ionic-hydrogen bonds is the major contribution to the reprocessibility of these materials.

Interface cisplatin-crosslinked doxorubicin-loaded triblock copolymer micelles for synergistic cancer therapy

2020 ◽  
Vol 196 ◽  
pp. 111334
Author(s):  
Xuedi Gao ◽  
Yujie Lu ◽  
Bin Wu ◽  
Jibin Miao ◽  
Peng Chen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Triblock Copolymer ◽  
Copolymer Micelles
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