scholarly journals Poly(ortho ester amides): Acid-Labile Temperature-Responsive Copolymers for Potential Biomedical Applications

2009 ◽  
Vol 10 (4) ◽  
pp. 722-727 ◽  
Author(s):  
Rupei Tang ◽  
R. Noelle Palumbo ◽  
Weihang Ji ◽  
Chun Wang
Keyword(s):  
Biomedical Applications ◽  
Ortho Ester ◽  
Temperature Responsive ◽  
Acid Labile

Acid-Labile Copolymer Micelles Cross-Linked by a Twin Ortho Ester Cross-Linking Agent: Synthesis, Characterization, and Evaluation

2016 ◽  
Vol 217 (19) ◽  
pp. 2182-2190 ◽  
Author(s):  
Xin Wang ◽  
Xiaojing Zhou ◽  
Jun Wang ◽  
Zhipeng Cao ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Cross Linking ◽  
Ortho Ester ◽  
Copolymer Micelles ◽  
Acid Labile

Temperature-responsive supramolecular hydrogels

2020 ◽  
Vol 8 (40) ◽  
pp. 9197-9211
Author(s):  
Sijie Xian ◽  
Matthew J. Webber
Keyword(s):  
Biomedical Applications ◽  
Supramolecular Interactions ◽  
Temperature Responsive

A subclass of hydrogels which are prepared from supramolecular interactions can realized enhanced functionality, especially in the context of biomedical applications, upon the inclusion of temperature-responsive properties.

Temperature-responsive hydrogels containing new LCST methacrylate macromonomers

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Anna Korytkowska-Wałach ◽  
Anna Porwoł ◽  
Mirosław Gibas
Keyword(s):  
Phase Transition ◽  
Biomedical Applications ◽  
Tetraethylene Glycol ◽  
Temperature Sensitive ◽  
Hydroxyethyl Methacrylate ◽  
Temperature Responsive ◽  
Michael Type Addition ◽  
Responsive Hydrogels ◽  
Ether Ester ◽  
Gel Transition

AbstractA series of hydrogels were synthesized: homopolymers of new temperature-sensitive methacrylate macromonomers of ether-ester structure, derived from monomethacrylate of tetraethylene glycol via Michael-type addition - oligo(TTEGMMA), and copolymers of oligo(TTEGMMA) with N-isopropylacrylamide (NIPAAm) or 2-hydroxyethyl methacrylate (HEMA). Hydrogels based on oligo(TTEGMMA) demonstrate broad volume phase transition. Combination of oligo(TTEGMMA) with NIPAAm or HEMA yielded hydrogels having narrower phase transition and lower gel transition temperature (LGTT) up to 43 °C at the most, which is in the range of interest for most biomedical applications.

scholarly journals Recent Advances in Dual Temperature Responsive Block Copolymers and Their Potential as Biomedical Applications

Polymers ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 380 ◽  
Author(s):  
Yohei Kotsuchibashi ◽  
Mitsuhiro Ebara ◽  
Takao Aoyagi ◽  
Ravin Narain
Keyword(s):  
Block Copolymers ◽  
Biomedical Applications ◽  
Temperature Responsive ◽  
Recent Advances

Acid-labile poly(amino alcohol ortho ester) based on low molecular weight polyethyleneimine for gene delivery

2017 ◽  
Vol 32 (3) ◽  
pp. 349-361 ◽  
Author(s):  
Jun Wang ◽  
Lei Zhang ◽  
Xin Wang ◽  
Shengxiang Fu ◽  
Guoqing Yan
Keyword(s):  
Molecular Weight ◽  
Amino Alcohol ◽  
Water Solubility ◽  
Transfection Efficiency ◽  
Enzymatic Digestion ◽  
Low Molecular Weight ◽  
Hydroxyl Groups ◽  
Ortho Ester ◽  
Human Neuroblastoma ◽  
Acid Labile

A series of acid-labile poly(amino alcohol ortho ester) (POEeis) were synthesized through ring-opening polymerization between diglycidyl ethers with ortho ester bonded and low molecular weight polyethyleneimine by various feed molar ratios. The obtain POEei 1 and POEei 2 exhibited clear kinetic of degradation and condensed plasmid DNA into nanoparticles of suitable sizes (250–300 nm) and positive zeta potentials (+20–30 mV) while protecting DNA from enzymatic digestion. Further, these polymers have uniform distribution of abundant hydroxyl groups, which could improve their water solubility, biocompatibility, and lower protein adsorption. Significantly, ortho ester groups in POEeis main-chains could hydrolyze rapidly at acidic endosomal pH, resulting in intracellular DNA release and diminished material toxicity. MTT assay revealed that all the polymers exhibited much lower cytotoxicity than 25 kDa PEI in the human neuroblastoma SH-SY5Y cells. Moreover, the transfection efficiency of POEei 1 was higher than 25 kDa PEI in serum-free medium or 10% serum medium.

PEGylated block copolymers containing tertiary amine side-chains cleavable via acid-labile ortho ester linkages for pH-triggered release of DNA

Polymer ◽  
2014 ◽  
Vol 55 (12) ◽  
pp. 2761-2771 ◽  
Author(s):  
Junping Lai ◽  
Zhangyan Xu ◽  
Rupei Tang ◽  
Weihang Ji ◽  
Rui Wang ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Tertiary Amine ◽  
Side Chains ◽  
Triggered Release ◽  
Ortho Ester ◽  
Acid Labile

Low Molecular Weight PEI-Based Vectors via Acid-Labile Ortho Ester Linkage for Improved Gene Delivery

2016 ◽  
Vol 16 (8) ◽  
pp. 1175-1187 ◽  
Author(s):  
Lei Zhang ◽  
Min Yu ◽  
Jun Wang ◽  
Rupei Tang ◽  
Guoqing Yan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
Ortho Ester ◽  
Ester Linkage ◽  
Acid Labile

Acid-Labile Temperature-Responsive Homopolymers and a Diblock Copolymer Bearing the Pendent Acetal Group

2021 ◽  
Author(s):  
Ke Wang ◽  
Qi Liu ◽  
Ganghui Lu ◽  
Yi Zhang ◽  
Yuanhong Zhou ◽  
...  
Keyword(s):  
Diblock Copolymer ◽  
Temperature Responsive ◽  
Acid Labile ◽  
Acetal Group
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