Multi‐Stimuli‐Responsive Polymeric Prodrug for Enhanced Cancer Treatment

2019 ◽  
Vol 19 (12) ◽  
pp. 1900329 ◽  
Author(s):  
Yue Wang ◽  
Na Shen ◽  
Kazuo Sakurai ◽  
Zhaohui Tang
Keyword(s):  
Cancer Treatment ◽  
Stimuli Responsive ◽  
Polymeric Prodrug

Functional nanoparticles of tea polyphenols for doxorubicin delivery in cancer treatment

2017 ◽  
Vol 5 (36) ◽  
pp. 7622-7631 ◽  
Author(s):  
Huaiying Zhang ◽  
Zeng Yi ◽  
Zhe Sun ◽  
Xiaomin Ma ◽  
Xudong Li
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Agents ◽  
Tea Polyphenols ◽  
Stimuli Responsive ◽  
Anticancer Efficacy ◽  
Functional Nanoparticles ◽  
Prepared Nanoparticles ◽  
Doxorubicin Delivery

Simply-prepared nanoparticles of tea polyphenols are biocompatible, stimuli-responsive carriers for therapeutic agents, resulting in enhanced anticancer efficacy.

Recent Progress in Stimuli Responsive Intelligent Nano Scale Drug Delivery Systems: A special focus towards pH sensitive systems

2021 ◽  
Vol 22 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Ruckmani Kandasamy
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Special Focus ◽  
Stimuli Responsive ◽  
Ph Variation ◽  
Responsive Systems

Abstract: Stimuli responsive nanocarriers are gaining much attention due to its versatile multifunctional activities including disease diagnosis and treatment. Recently, clinical applications of nano drug delivery systems for cancer treatment make a considerable challenge due to its limited cellular uptake, low bioavailability, poor targetability, stability issues, and unfavourable pharmacokinetics. To overcome these issues researchers are focussing on stimuli responsive systems. Nano carriers elicit its role through endogenous (pH, temperature, enzyme and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimulus. These systems were designed to overcome the shortcomings such as non-specificity and toxicity associated with the conventional drug delivery systems. The pH variation between healthy cells and tumor microenvironment creates a platform towards the generation of pH sensitive nano delivery systems. Herein, we propose to present an overview of various internal and external stimuli responsive behavior based drug delivery systems. Herein the present review will focus specifically on the significance of various pH- responsive nanomaterials such as polymeric nanoparticles, nano micelles, inorganic based pH sensitive drug delivery carriers such as calcium phosphate nanoparticles, and carbon dots in cancer treatment. Moreover, this review elaborates the recent findings on pH based stimuli responsive drug delivery system with special emphasis towards our reported stimuli responsive systems for cancer treatment.

Photo-triggered release of doxorubicin from liposomes formulated by amphiphilic phthalocyanines for combination therapy to enhance antitumor efficacy

2020 ◽  
Vol 8 (35) ◽  
pp. 8022-8036
Author(s):  
Ke Zheng ◽  
Hongyan Liu ◽  
Xinxin Liu ◽  
Libin Jiang ◽  
Linlin Li ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Antitumor Efficacy ◽  
Stimuli Responsive ◽  
Triggered Release

Multidrug combination therapy based on stimuli-responsive liposomes formulated by amphiphilic phthalocyanines has great potential for cancer treatment.

Tumor Microenvironment Stimuli-Responsive Polymeric Prodrug Micelles for Improved Cancer Therapy

2019 ◽  
Vol 37 (1) ◽  
Author(s):  
Zhiqiang Zhang ◽  
Miao Yu ◽  
Tong An ◽  
Jun Yang ◽  
Meijuan Zou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Stimuli Responsive ◽  
Polymeric Prodrug

scholarly journals A Nanostrategy for Efficient Imaging‐Guided Antitumor Therapy through a Stimuli‐Responsive Branched Polymeric Prodrug

2020 ◽  
Vol 7 (6) ◽  
pp. 1903243 ◽  
Author(s):  
Hao Cai ◽  
Xinghang Dai ◽  
Xiaoming Wang ◽  
Ping Tan ◽  
Lei Gu ◽  
...  
Keyword(s):  
Stimuli Responsive ◽  
Antitumor Therapy ◽  
Polymeric Prodrug

Reduction stimuli-responsive unimolecular polymeric prodrug based on amphiphilic dextran-framework for antitumor drug delivery

2018 ◽  
Vol 182 ◽  
pp. 235-244 ◽  
Author(s):  
Shuang Bai ◽  
Yong-E Gao ◽  
Xiaoqian Ma ◽  
Xiaoxiao Shi ◽  
Meili Hou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Drug ◽  
Stimuli Responsive ◽  
Polymeric Prodrug
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