The pediatric end-stage liver disease (PELD) model as a predictor of survival benefit and posttransplant survival in pediatric liver transplant recipients

2006 ◽  
Vol 12 (3) ◽  
pp. 475-480 ◽  
Author(s):  
Neal R. Barshes ◽  
Timothy C. Lee ◽  
Ian W. Udell ◽  
Christine A. O'Mahoney ◽  
Saul J. Karpen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Transplant ◽  
Survival Benefit ◽  
Transplant Recipients ◽  
End Stage Liver Disease ◽  
Pediatric Liver ◽  
End Stage ◽  
Liver Transplant Recipients ◽  
Pediatric Liver Transplant

Preoperative Trapped Lung Is Associated With Increased Mortality After Orthotopic Liver Transplantation

2020 ◽  
pp. 152692482097860
Author(s):  
Kathryn H. Melamed ◽  
David Dai ◽  
Natasha Cuk ◽  
Daniela Markovic ◽  
Robert Follett ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Liver Transplant ◽  
Orthotopic Liver Transplantation ◽  
Meld Score ◽  
Transplant Recipients ◽  
End Stage Liver Disease ◽  
Trapped Lung ◽  
End Stage ◽  
Liver Transplant Recipients

Introduction: Trapped lung, characterized by atelectatic lung unable to reexpand and fill the thoracic cavity due to a restricting fibrous visceral pleural peel, is occasionally seen in patients with end-stage liver disease complicated by hepatic hydrothorax. Limited data suggest that trapped lung prior to orthotopic liver transplantation may be associated with poor outcomes. Research Question: What is the clinical significance of trapped lung in patients receiving orthotopic liver transplantation? Design: We performed a retrospective analysis of patients who underwent liver transplantation over an 8-year period. Baseline clinical characteristics and postoperative outcomes of adult patients with trapped lung were analyzed and compared to the overall cohort of liver transplant recipients and controls matched 3:1 based on age, sex, Model for End-Stage Liver Disease (MELD) score, and presence of pleural effusion. Results: Of the 1193 patients who underwent liver transplantation, we identified 20 patients (1.68%) with trapped lung. The probability of 1 and 2-year survival were 75.0% and 57.1%, compared to 85.6% and 80.4% (p = 0.02) in all liver transplant recipients and 87.9% and 81.1% (p = 0.03) in matched controls respectively. Patients with trapped lung had a longer hospital length of stay compared to the total liver transplant population (geometric mean 54.9 ± 8.4 vs. 27.2 ± 0.7 days, p ≤ 0.001), when adjusted for age and MELD score. Discussion: Patients with trapped prior to orthotopic liver transplantation have increased probability of mortality as well as increased health care utilization. This is a small retrospective analysis, and further prospective investigation is warranted.

scholarly journals Survival outcomes in liver transplant recipients with Model for End‐stage Liver Disease scores of 40 or higher: a decade‐long experience

HPB ◽  
2015 ◽  
Vol 17 (12) ◽  
pp. 1074-1084 ◽  
Author(s):  
Hina J. Panchal ◽  
Joel B. Durinka ◽  
Jeromy Patterson ◽  
Farah Karipineni ◽  
Sarah Ashburn ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Transplant ◽  
Survival Outcomes ◽  
Transplant Recipients ◽  
End Stage Liver Disease ◽  
End Stage ◽  
Liver Transplant Recipients

scholarly journals Model of end stage liver disease (MELD) score greater than 23 predicts length of stay in the ICU but not mortality in liver transplant recipients

Critical Care ◽  
2010 ◽  
Vol 14 (3) ◽  
pp. R117 ◽  
Author(s):  
Christian E Oberkofler ◽  
Philipp Dutkowski ◽  
Reto Stocker ◽  
Reto A Schuepbach ◽  
John F Stover ◽  
...  
Keyword(s):  
Liver Disease ◽  
Length Of Stay ◽  
Liver Transplant ◽  
Meld Score ◽  
Transplant Recipients ◽  
End Stage Liver Disease ◽  
End Stage ◽  
Liver Transplant Recipients

scholarly journals CLINICAL SIGNIFICANCE OF CYTOMEGALOVIRUS INFECTION IN PEDIATRIC LIVER TRANSPLANT RECIPIENTS

2016 ◽  
Vol 18 (1) ◽  
pp. 67-77 ◽  
Author(s):  
O. M. Tsiroulnikova ◽  
I. V. Zhilkin ◽  
D. G. Akhaladze
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Graft Loss ◽  
Transplant Recipients ◽  
Cmv Infection ◽  
Pediatric Liver ◽  
Life Saving ◽  
End Stage ◽  
Liver Transplant Recipients ◽  
Pediatric Liver Transplant

Liver transplantation is a life-saving procedure for many forms of end-stage liver disease in pediatrics. Cytomegalovirus (CMV) is the most common and signifi cant posttransplant infection after pediatric liver transplant (PLT) with developing an episode of CMV infection or disease. It is well known that CMV increases risk of graft loss. The review presents aspects of etiology and epidemiology of CMV after PLT, approaches employed in diagnostics and prophylaxis of CMV, algorithms for valganciclovir dosing and methods to prevent complications associated with CMV. The latest data on current prevention strategies in pediatric liver transplantation centers in the world are also presented.

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