Comparative quantative analysis of zinc, magnesium, and copper content in the scalp hair of healthy people and breast cancer patients

2004 ◽  
Vol 17 (3) ◽  
pp. 175-180 ◽  
Author(s):  
Eser Kilic ◽  
Asuman Demiroglu ◽  
Recep Saraymen ◽  
Engin Ok
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Copper Content ◽  
Scalp Hair ◽  
Healthy People ◽  
Breast Cancer Patients

scholarly journals Medulla loss of scalp hair in breast cancer patients determined by near-infrared microscopy

2019 ◽  
Vol 24 (09) ◽  
pp. 1
Author(s):  
Younshick Choi ◽  
Young-Ju Jeong ◽  
Jae-Geun Jeon ◽  
Sung-Hwan Park ◽  
Hye-Ryeon Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Near Infrared ◽  
Scalp Hair ◽  
Breast Cancer Patients ◽  
Infrared Microscopy

scholarly journals Comparing the Metal Concentration in the Hair of Cancer Patients and Healthy People Living in the Malwa Region of Punjab, India

2014 ◽  
Vol 8 ◽  
pp. CMO.S13410 ◽  
Author(s):  
Eleonore Blaurock-Busch ◽  
Yvette M. Busch ◽  
Albrecht Friedle ◽  
Holger Buerner ◽  
Chander Parkash ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Healthy People ◽  
Control Group ◽  
Reference Ranges ◽  
Breast Cancer Patients ◽  
Cancer Prevalence ◽  
Hair Samples ◽  
Patient Groups ◽  
High Concentrations

The cancer prevalence in the Malwa region of Punjab (1089/million/year) is much higher than the national average cancer prevalence in India (800/million/year). The participants in the present study were 50 healthy individuals and 49 cancer patients all living in the Malwa region of Punjab, with the healthy people being selected from the same household as the cancer patients. High concentrations of several potentially toxic elements were found in hair samples from people living in Punjab. Compared to standard reference ranges, the metals in excess in both the control and patient groups were aluminium (Al), barium (Ba), manganese (Mn), strontium (Sr) and uranium (U). The most significant findings were high lead (Pb), U and Ba concentrations. The maximum values for Ba, Mn, Pb and U were found in hair from breast cancer patients. The mean concentration of U in hair from the breast cancer patients was 0.63 μg U/g, which is more than double the value found in the control group and over six times higher than the reference range of 0.1 μg U/g. Water, soil, and phosphate fertilizers all seem to play a potential role, causing an increased metal burden in Punjabi people living in the Malwa region. The present study indicates that metals, and especially U, may be a factor in the development of breast cancer among Punjabi women.

scholarly journals Identification of Breast Cancer-Associated Lipids in Scalp Hair

2012 ◽  
Vol 6 ◽  
pp. BCBCR.S9607 ◽  
Author(s):  
Dharmica A.H. Mistry ◽  
Joseph Haklani ◽  
Peter W. French
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Biological Samples ◽  
Molecular Mechanisms ◽  
Scalp Hair ◽  
Breast Cancer Patients ◽  
X Ray Diffraction ◽  
Xrd Pattern ◽  
X Ray

A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date, the molecular mechanisms leading to this alteration are largely unknown. We have determined that the alteration is likely to be due to the presence of one or more breast cancer-associated phospholipids. Further characterization of these lipids could be used to develop a novel, sensitive and specific screening test for breast cancer, based on hair initially, and potentially extendable to other biological samples.

scholarly journals Clinical Potential of miR-451 and miR-506 as a Prognostic Biomarker in Patients with Breast Cancer

2022 ◽  
Vol 2022 ◽  
pp. 1-6
Author(s):  
Yu Du ◽  
Zhuang Miao ◽  
Lijuan Qiu ◽  
Yan Lv ◽  
Kedi Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diagnostic Accuracy ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Healthy People ◽  
Breast Cancer Patients ◽  
Operating Characteristics ◽  
Node Metastasis ◽  
Tumor Node Metastasis Stage ◽  
Incidence And Mortality

Background. The incidence and mortality of breast cancer in the world remain high. The function and important role of miR-451 and miR-506 in a series of cancers have been proved. The purpose of this research was to explore the clinical diagnosis and prognostic significance of miR-451 and miR-506 expression in breast cancer. Methods. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect miR-451 and miR-506 expression in serum and tissues. The relationship of miR-451 and miR-506 with clinical parameters was determined by the chi-square test. Receiver operating characteristics (ROC) analysis was conducted to evaluate the diagnostic accuracy of miR-451 and miR-506 in breast cancer. In addition, we determined the prognostic performance of miR-451 and miR-506 using Kaplan–Meier survival assay. Results. The expression of miR-451 and miR-506 in breast cancer patients was significantly lower than that in healthy people. miR-451 and miR-506 expression decreased in breast cancer tissues compared with paracancerous tissue. High expression of miR-451 and miR-506 was associated with positive lymph node metastasis and late tumor node metastasis stage. Breast cancer patients with high miR-451 and miR-506 expression had lower five-year survival rate. The level of miR-451 and miR-506 expression showed high diagnostic accuracy for distinguishing breast cancer patients and healthy people. Conclusion. miR-451 and miR-506 could be used as biomarker for the diagnosis and prognosis of breast cancer.

Trace element abnormalities in the scalp hair of breast cancer patients

2014 ◽  
Vol 24 (01n02) ◽  
pp. 49-58 ◽  
Author(s):  
Z. Kabiri ◽  
O. Kakuee ◽  
V. Fathollahi ◽  
B. Stout
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Trace Element ◽  
Cancer Patients ◽  
Scalp Hair ◽  
Healthy Controls ◽  
Meaningful Difference ◽  
Breast Cancer Patients ◽  
X Ray ◽  
Significant Difference

Development of a number of diseases like cardiovascular diseases and cancer has been related with abnormalities of certain trace elements in some tissues. The purpose of this study was to investigate the levels of trace elements in breast cancer patients in comparison with healthy controls. Particle induced X-ray emission (PIXE) technique was employed to measure the hair trace element concentrations in 30 cancer patients and 30 healthy controls. A 2.2 MeV proton beam was employed to excite the biological samples. The concentrations of Fe and Cu ([Formula: see text]) in the hair of cancer patients were found to be higher compared to those of healthy controls, while the concentration of Zn ([Formula: see text]) was found to be lower. No significant difference was observed for sulfur concentration between the two groups. Also, no meaningful difference was observed in the concentrations of K, Ca, Ti as well as ratios of Cu/Zn and Cu/Fe in the hair of the two groups ([Formula: see text]). These abnormalities could potentially be used as a means of breast cancer screening in women.

scholarly journals Faktor risiko dan asupan isoflavon pada pasien kanker payudara

2014 ◽  
Vol 10 (4) ◽  
pp. 218
Author(s):  
I Wayan Dwija Karyasa ◽  
Johan Kurnianda ◽  
Herni Astuti
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Cancer Patients ◽  
Hormone Replacement ◽  
Healthy People ◽  
Health Examination ◽  
Breast Cancer Patients ◽  
Oncologic Surgery ◽  
The Status ◽  
The Difference

Background: Breast cancer is noncommunicable chronic disease the prevalence of which is increasing all over the world, including in Indonesia and particularly East Java. Causes of breast cancer are unknown. Some studies show risk factors for breast cancer are hormonal, genetic, reproductive and endocrinologic factors. There is the isoflavon compound in soybeans that is known as anti-cancer with anti-estrogen activities.Objective: The study was aimed at identifying risk factor and the difference of isoflavone intake between breast cancer patients and healthy people in hospitals.Method: The study was analytic observational using matched case-control study design at comparison 1:2 with matching on a status of menopause. Cases were positive receptor estrogen breast cancer patients newly diagnosed during the first visit at hospital outpatient Oncologic Surgery Polyclinic. Controls were staff considered healthy based on the result of health examination at Dr. Ramelan Naval Hospital of Surabaya. Cases comprised 49 people and control 98 people taken through consecutive method. Data consisted of an identity of samples, weight, height, isoflavone intake, family history, use of hormone replacement therapy and parity. Intake of isoflavones was obtained from semiquantitative food frequency questionnaire (SQ-FFQ) and statistical test used Chi-Square and Odd Ratio (OR).Results: There was the difference in isoflavone intake and family history between cases and controls (p<0.05) and there was an association between isoflavone intake (OR=2.58; p=0.007) and family history (OR=18; p=0.002) and the incidence of breast cancer. There was no association between the status of obesity, parity, and use of hormone replacement therapy.Conclusion: There are differences in isoflavone intake of breast cancer patients compared with healthy people and there was no difference in the status of obese breast cancer patients compared to healthy individuals and isoflavone intake less 2.85 times the risk of breast cancer compared with adequate intake of isoflavones.

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