The utility of silica hydride‐based stationary phases for dual‐mode ultra high performance liquid chromatography separation of synthetic cathinone positional isomers

2020 ◽  
Vol 43 (17) ◽  
pp. 3449-3457 ◽  
Author(s):  
Carly Ploumen ◽  
Ioan Marginean ◽  
Ira S. Lurie
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Stationary Phases ◽  
Positional Isomers ◽  
Dual Mode ◽  
Silica Hydride ◽  
Liquid Chromatography Separation ◽  
Synthetic Cathinone

Reverse-phase high performance liquid chromatography separation of positional isomers on a MIL-53(Fe) packed column

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40094-40102 ◽  
Author(s):  
Zhiming Yan ◽  
Wenmin Zhang ◽  
Jia Gao ◽  
Yifen Lin ◽  
Jianrong Li ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Metal Organic Framework ◽  
Packed Column ◽  
Positional Isomers ◽  
Reverse Phase ◽  
Liquid Chromatography Separation ◽  
Metal Organic ◽  
First Time

The application of the metal–organic framework (MOF) MIL-53(Fe) as a novel stationary phase for reverse-phase high performance liquid chromatography (HPLC) separation of positional isomers is described for the first time.

scholarly journals The Development of Silica Hydride Stationary Phases for High-Performance Liquid Chromatography from Conception to Commercialization

Separations ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 27 ◽  
Author(s):  
Maria Matyska ◽  
Joseph Pesek
Keyword(s):  
High Performance Liquid Chromatography ◽  
Surface Modification ◽  
Liquid Chromatography ◽  
Stationary Phase ◽  
High Performance ◽  
Silica Surface ◽  
Stationary Phases ◽  
Retention Mechanism ◽  
Silica Hydride ◽  
Synthetic Approaches

The development of a stationary phase material for high-performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization, and applications. There are several synthetic approaches available to create a silica hydride surface. Modification of the Si–H moiety on the silica surface can be accomplished through the use of a hydrosilation reaction. Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods. Further insights into the retention mechanism are provided through chromatographic measurements. The ultimate utility of any chromatographic stationary phase material is determined by its success in solving challenging analytical problems. A broad range of applications is reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases.

scholarly journals The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization

2019 ◽  
Author(s):  
Maria Matyska ◽  
Joseph Pesek
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Stationary Phase ◽  
High Performance ◽  
Silica Surface ◽  
Stationary Phases ◽  
Retention Mechanism ◽  
Organic Moiety ◽  
Silica Hydride ◽  
Synthetic Approaches

The development of a stationary phase material for high performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization and applications.  There are several synthetic approaches available to create a silica hydride surface.  Modification of the Si-H moiety on the silica surface can be accomplished through use of a hydrosilation reaction.  Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods.  Further insights into the retention mechanism are provide through chromatographic measurements.  The ultimate utility of any chromatographic stationary phase material is determined by its success for solving challenging analytical problems.  A broad range of applications are reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases. 

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