The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization

The development of a stationary phase material for high performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization and applications.  There are several synthetic approaches available to create a silica hydride surface.  Modification of the Si-H moiety on the silica surface can be accomplished through use of a hydrosilation reaction.  Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods.  Further insights into the retention mechanism are provide through chromatographic measurements.  The ultimate utility of any chromatographic stationary phase material is determined by its success for solving challenging analytical problems.  A broad range of applications are reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases. 

Dielectric phase transition triggered by the order–disorder transformation of cyclopropylamine in a layered organic–inorganic halide perovskite

We used cyclopropylamine to construct a new layered inorganic–organic hybrid phase transition compound, which undergoes a solid-state phase transition around 273 K induced by the order–disorder transformation of organic moiety.

Regression of murine Ehrlich ascites carcinoma using synthesized cobalt complex

Cisplatin as a chief chemotherapy has nephro-toxicity and so we have tried to develop a novel antitumor drug based on a combination of cobalt metal ion with an organic moiety.