Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet

2011 ◽  
Vol 92 (2) ◽  
pp. 388-396 ◽  
Author(s):  
Yong-Bum Song ◽  
Yu Ri An ◽  
Seung Jun Kim ◽  
Hye-Won Park ◽  
Jin-Wook Jung ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Effect ◽  
Red Ginseng ◽  
High Fat ◽  
Korean Red Ginseng ◽  
Ginseng Extract

scholarly journals Gut Microbiome Prolongs an Inhibitory Effect of Korean Red Ginseng on High-Fat-Diet-Induced Mouse Obesity

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 926
Author(s):  
Seo Yeon Lee ◽  
Hyun Gyun Yuk ◽  
Seong Gyu Ko ◽  
Sung-Gook Cho ◽  
Gi-Seong Moon
Keyword(s):  
Plasma Glucose ◽  
Gut Microbiome ◽  
High Fat Diet ◽  
Inhibitory Effect ◽  
Red Ginseng ◽  
High Fat ◽  
Korean Red Ginseng ◽  
Ginseng Extract ◽  
Islet Size ◽  
Mouse Obesity

Although the anti-obesity effect of Korean red ginseng (Panax ginseng Meyer) has been revealed, its underlying mechanisms are not clearly understood. Here, we demonstrate an involvement of gut microbiome in the inhibitory effect of Korean red ginseng on high-fat-diet (HFD)-induced mouse obesity, and further provides information on the effects of saponin-containing red ginseng extract (SGE) and saponin-depleted red ginseng extract (GE). Mice were fed with either SGE or GE every third day for one month, and their food intakes, fat weights, plasma glucose, and insulin and leptin levels were measured. Immunofluorescence assays were conducted to measure pancreatic islet size. Stools from the mice were subjected to metagenomic analysis. Both SGE and GE attenuated HFD-induced gain of body weight, reducing HFD-induced increase of food intakes and fat weights. They also reduced HFD-increased plasma glucose, insulin, and leptin levels, decreased both fasting and postprandial glucose concentrations, and improved both insulin resistance and glucose intolerance. Immunofluorescence assays revealed that they blocked HFD-induced increase of pancreatic islet size. Our pyrosequencing of the 16S rRNA gene V3 region from stools revealed that both SGE and GE modulated HFD-altered composition of gut microbiota. Therefore, we conclude that Korean red ginseng inhibits HFD-induced obesity and diabetes by altering gut microbiome.

scholarly journals Effect of Crude Saponin of Korean Red Ginseng on High-Fat Diet-Induced Obesity in the Rat

2005 ◽  
Vol 97 (1) ◽  
pp. 124-131 ◽  
Author(s):  
Ji Hyun Kim ◽  
Dae Hyun Hahm ◽  
Deck Chun Yang ◽  
Jang Hyun Kim ◽  
Hye Jung Lee ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Red Ginseng ◽  
High Fat ◽  
Korean Red Ginseng ◽  
Diet Induced Obesity ◽  
Crude Saponin

Multi-tissue lipotoxicity caused by high-fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

2019 ◽  
Vol 16 (1) ◽  
pp. 39-50
Author(s):  
Seon-A Jang ◽  
Seung Namkoong ◽  
Sung Ryul Lee ◽  
Jin Woo Lee ◽  
Yuna Park ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Red Ginseng ◽  
High Fat ◽  
Korean Red Ginseng
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