Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes

2011 ◽  
Vol 91 (14) ◽  
pp. 2551-2557 ◽  
Author(s):  
Cristina dos Santos ◽  
María P Buera ◽  
María F Mazzobre
Keyword(s):  
Inclusion Complexes ◽  
Phase Solubility ◽  
Cyclodextrin Inclusion Complexes ◽  
Cyclodextrin Inclusion ◽  
Phase Solubility Studies ◽  
Solubility Studies

STUDIES ON METFORMIN HYDROCHLORIDE AND ALPHA-CYCLODEXTRIN INCLUSION COMPLEXES

2015 ◽  
Vol 1 (01) ◽  
pp. 48-53 ◽  
Author(s):  
S. Lizy Roselet, ◽  
Dr J Premakumari
Keyword(s):  
Type 2 Diabetes ◽  
Inclusion Complexes ◽  
Spectroscopic Studies ◽  
Metformin Hydrochloride ◽  
Phase Solubility ◽  
Solution State ◽  
Cyclodextrin Inclusion Complexes ◽  
Cyclodextrin Inclusion ◽  
Solubility Studies

Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type-2 diabetes. Inclusion complexes were prepared between Metformin hydrochloride and alpha- cyclodextrin  in solid and solution state. Inclusion complexes were characterised using UV-VIS, Fluorescence and FTIR Spectroscopic Studies. Phase solubility studies were carried out which determined the 1:1 stoichiometry for the formation of inclusion complexes.

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