Aspirin—A National Survey V: Determination of Aspirin and Impurities in Enteric Coated Tablets and Suppository Formulations and In Vitro Dissolution of Enteric Coated Tablets

1982 ◽  
Vol 71 (9) ◽  
pp. 1049-1052 ◽  
Author(s):  
Ross D. Kirchhoefer ◽  
Everett Jefferson ◽  
Paul E. Flinn
Keyword(s):  
National Survey ◽  
In Vitro Dissolution ◽  
Enteric Coated

scholarly journals Development and Validation of an Eco-friendly HPLC-UV-DAD Method for the Determination of Allopurinol in Pharmaceuticals with Application to In vitro Dissolution Studies

2021 ◽  
Vol 11 (5) ◽  
pp. 13089-13101
Keyword(s):  
Factorial Design ◽  
Matrix Effects ◽  
Dissolution Kinetics ◽  
In Vitro Dissolution ◽  
Dissolution Test ◽  
Dissolution Studies ◽  
Dissolution Tests ◽  
Development And Validation

In this study, a sustainable HPLC-UV-DAD method was developed and validated for the determination of allopurinol in tablets and optimization of the dissolution test using factorial design. The separation of the analyte from the sample matrix was achieved in 3.01 minutes in a C8 column (4.6 mm X 150 mm X 5 μm), using mobile phase 0.1 mol L-1 HCl (25%) + ethanol (50%) + ultrapure water (25%) by UV detection at 249 nm. The method presented satisfactory analytical parameters of validation (specificity, selectivity, linearity, stability, precision, accuracy, and robustness), showing no matrix effects. The dissolution test was optimized by complete factorial design 23 and, the optimal conditions were: HCl 0.001 mol L-1, apparatus II (paddle) and 75 rpm. The analytical procedures and dissolution tests were applied to allopurinol tablets marketed in Bahia, Brazil, to evaluate the dissolution studies. The pharmaceuticals had similar dissolution profiles and first-order dissolution kinetics. This new and sustainable HPLC-UV-DAD method is friendly to the environment and can be used for the routine pharmaceutical analysis of allopurinol in fixed dosage forms.

scholarly journals LC Determination of Entacapone in Tablets: In Vitro Dissolution Studies

2010 ◽  
Vol 48 (9) ◽  
pp. 755-759 ◽  
Author(s):  
C. S. Paim ◽  
M. T. Martins ◽  
M. D. Malesuik ◽  
M. Steppe
Keyword(s):  
In Vitro Dissolution ◽  
Dissolution Studies

In vitro dissolution profiles of enteric-coated microsphere/microtablet pancreatin preparations at different pH values

1996 ◽  
Vol 10 (5) ◽  
pp. 771-775 ◽  
Author(s):  
K.-H. GAN ◽  
W. P. GEUS ◽  
W. BAKKER ◽  
C. B. H. W. LAMERS ◽  
H. G. M. HEIJERMAN
Keyword(s):  
In Vitro Dissolution ◽  
Ph Values ◽  
Enteric Coated

scholarly journals Formulation and In-Vitro Evaluation of Enteric Coated Tablet Incorporating Rabeprazole

2020 ◽  
Vol 10 (2-s) ◽  
pp. 50-57
Author(s):  
Gautam D. Mehetre ◽  
Rameshwar S. Cheke ◽  
Vinayak N. Shrikhande
Keyword(s):  
Drug Release ◽  
Acid Resistance ◽  
Tablet Formulation ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
In Vitro Evaluation ◽  
Enteric Coated Tablet ◽  
Coated Tablet ◽  
Enteric Coated

The objective of the work is to try and assess the applicability and manufacturing possibilities to optimize an enteric coated tablet formulation containing Rabeprazole sodium as the drug aiming at the anti-acidity activity with desired drug release properties. Enteric coated tablet was chosen as dosage form being a cost-effective technology for pharmaceutical industry requiring fewer procedures. Before the implementation of the pharmaceutical technological aims, analysis of critical factors influencing the manufacture was carried out. Reproducible manufacturing processes are required to achieve suitability and tablets uniformity to achieve the uniform properties of tablets, which could influence experimental parameters. Rabeprazole in core content of tablet is blended with HPMC (different grades), xanthan gum, PVPK30, mannitol, crosspovidone, Sodium starch glycolate, Colloidal silicon dioxide to formulate the product. Prepared formulation was tested for weight and content uniformity, physical characteristics, in vitro dissolution behaviour, acid resistance and accelerated stability studies. All studies performed resulted and revealed for assurance of such enteric coated tablet formulation for drug Rabeprazole with optimum characteristics, concluding it as a promising approach to enhance drug release characteristics. Keywords: Rabeprazole, HPMC, enteric coated tablets, In Vitro evaluation.

scholarly journals Development and application of a validated HPLC method for the analysis of dissolution samples of mexiletine hydrochloride capsules

2010 ◽  
Vol 75 (7) ◽  
pp. 975-985 ◽  
Author(s):  
Dragan Milenovic ◽  
Zoran Todorovic
Keyword(s):  
Flow Rate ◽  
Mobile Phase ◽  
Hplc Method ◽  
Uv Detection ◽  
In Vitro Dissolution ◽  
Selective Method ◽  
Dissolution Studies ◽  
Detection And Quantification

The aim of this work was to develop and validate a simple, efficient, sensitive and selective method for the analysis of dissolution samples of mexiletine hydrochloride capsules by HPLC without the necessity of any time-consuming extraction, dilution or evaporation steps prior to drug assay. Separation was performed isocratically on a 5 ?m LiChrospher 60, RP-Select B column (250 x 4 mm ID) using the mobile phase buffer-acetonitrile (60:42, v/v) at a flow rate of 1.2 mL min-1 and UV detection at 262 nm. The elution occurred in less than 10 minutes. The assay was linear in the concentration range 50-300 ?g mL-1 (r2 = 0.9998). The validation characteristics included accuracy, precision, linearity, specificity, limits of detection and quantification, stability, and robustness. Validation acceptance criteria were met in all cases (the percent recoveries ranged between 100.01 and 101.68 %, RSD < 0.44 %). The method could be used for the determination of mexiletine hydrochloride and for monitoring its concentration in in vitro dissolution studies.

scholarly journals Study of Release-Retardant Polymers in Formulation Development of Cinnarizine-HCl Sustained-release Oral Suspension Using Raft Technology

2020 ◽  
Vol 19 (1) ◽  
pp. 14-24
Author(s):  
Tabinda Islam ◽  
Nusrat Hossain ◽  
Mohsina Rahman ◽  
Sadia Shabnam ◽  
Eyasmin Chowdhury ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Vitro Dissolution ◽  
Formulation Development ◽  
Hydrochloric Acid Medium ◽  
Sodium Saccharin ◽  
Physical Mixing ◽  
Mixing Method ◽  
Usp Apparatus

The main objective of this research was to develop a sustained-release suspension of cinnarizine hydrochloride using raft-forming technique. This innovative approach has been utilized to formulate a series of suspension formulations using hydroxypropyl cellulose (HPC) as a release-retardant polymeric agent. Cinnarizine sustained-release suspensions were prepared by physical mixing method with varying concentrations and combinations of HPC, sodium citrate, sodium saccharin, calcium carbonate, sodium alginate, methyl hydroxybenzoate and propyl hydroxybenzoate. The formulations were subjected for determination of floating time, floating lag time, weight of the raft, physical appearance and in-vitro dissolution. The dissolution was conducted through USP apparatus 2 (paddle type) in 0.1N hydrochloric acid medium having pH 1.2. The key findings of the study demonstrate that a stable sustained-release suspension of cinnarizine can be formulated using raft-forming approach for increased bioavailability and patient-convenience. Dhaka Univ. J. Pharm. Sci. 19(1): 15-24, 2020 (June)

Design and Development of Microparticulate Drug Delivery System of Hydrochlorothiazide

1970 ◽  
Vol 9 (3) ◽  
pp. 3282-3286
Author(s):  
S.S. Sakhare ◽  
A.K. Mali
Keyword(s):  
Drug Delivery ◽  
Solid Particles ◽  
In Vitro Dissolution ◽  
Uniform Size ◽  
Dissolution Properties ◽  
Particle Size Determination ◽  
Evaporation Technique ◽  
Novel Drug

Microparticles open up new vistas of research in the development of novel drug delivery systems. Microparticles are defined as particulate dispersions or solid particles with size range of 1-1000 µm.  Hydrochlorothiazide (HCT), diuretic drug, is practically insoluble in water and has a solubility of 250µg/mL in 0.1 N HCl (25 °C). Presently, the improvement of drug solubility is one of the most challenging fields in pharmaceutical development, therefore, we choose hydrochlorothiazide for the micro-particulate drug delivery. Microparticles of hydrochlorothiazide were prepared by solvent evaporation technique. The prepared microparticles were evaluated for various properties. Particle size determination of microparticles by optical microscopy showed uniform size distribution. The in vitro dissolution studies of hydrochlorothiazide microparticles showed better release effect (99.45%) over a period of 60 min as compared to pure drug. Thus a successful attempt was made to formulate microparticles of this BCS class II drug which resulted in increase in dissolution properties of hydrochlorothiazide microparticles.

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