scholarly journals Bioavailability of pyridoxal phosphate from enteric-coated tablets. III. Correlations between bioavailability in humans and beagle dogs and between bioavailability in humans and in vitro dissolution rates.

1985 ◽  
Vol 33 (9) ◽  
pp. 3906-3914 ◽  
Author(s):  
NAHOKO KANIWA ◽  
HIROYASU OGATA ◽  
NOBUO AOYAGI ◽  
MASANOBU KOIBUCHI ◽  
TOSHIO SHIBAZAKI ◽  
...  
Keyword(s):  
Pyridoxal Phosphate ◽  
In Vitro Dissolution ◽  
Beagle Dogs ◽  
Dissolution Rates ◽  
Enteric Coated

In vitro dissolution profiles of enteric-coated microsphere/microtablet pancreatin preparations at different pH values

1996 ◽  
Vol 10 (5) ◽  
pp. 771-775 ◽  
Author(s):  
K.-H. GAN ◽  
W. P. GEUS ◽  
W. BAKKER ◽  
C. B. H. W. LAMERS ◽  
H. G. M. HEIJERMAN
Keyword(s):  
In Vitro Dissolution ◽  
Ph Values ◽  
Enteric Coated

scholarly journals Formulation and In-Vitro Evaluation of Enteric Coated Tablet Incorporating Rabeprazole

2020 ◽  
Vol 10 (2-s) ◽  
pp. 50-57
Author(s):  
Gautam D. Mehetre ◽  
Rameshwar S. Cheke ◽  
Vinayak N. Shrikhande
Keyword(s):  
Drug Release ◽  
Acid Resistance ◽  
Tablet Formulation ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
In Vitro Evaluation ◽  
Enteric Coated Tablet ◽  
Coated Tablet ◽  
Enteric Coated

The objective of the work is to try and assess the applicability and manufacturing possibilities to optimize an enteric coated tablet formulation containing Rabeprazole sodium as the drug aiming at the anti-acidity activity with desired drug release properties. Enteric coated tablet was chosen as dosage form being a cost-effective technology for pharmaceutical industry requiring fewer procedures. Before the implementation of the pharmaceutical technological aims, analysis of critical factors influencing the manufacture was carried out. Reproducible manufacturing processes are required to achieve suitability and tablets uniformity to achieve the uniform properties of tablets, which could influence experimental parameters. Rabeprazole in core content of tablet is blended with HPMC (different grades), xanthan gum, PVPK30, mannitol, crosspovidone, Sodium starch glycolate, Colloidal silicon dioxide to formulate the product. Prepared formulation was tested for weight and content uniformity, physical characteristics, in vitro dissolution behaviour, acid resistance and accelerated stability studies. All studies performed resulted and revealed for assurance of such enteric coated tablet formulation for drug Rabeprazole with optimum characteristics, concluding it as a promising approach to enhance drug release characteristics. Keywords: Rabeprazole, HPMC, enteric coated tablets, In Vitro evaluation.

Formulation and Evaluation of Novel Enteric Coated Extended Release Multiparticulates of Model NSAID Ketoprofen

2010 ◽  
Vol 3 (2) ◽  
pp. 994-999
Author(s):  
Lotlikar V ◽  
S Shidhaye ◽  
U Kedar ◽  
V Kadam
Keyword(s):  
Rheumatoid Arthritis ◽  
Dosage Form ◽  
Extended Release ◽  
In Vitro Dissolution ◽  
Ph Responsive ◽  
Model Drug ◽  
Enteric Coated ◽  
Pan Coater ◽  
Barrier Coat

The aim of this study was to develop a pH responsive enteric coated extended release multiparticulate dosage form containing a model drug ketoprofen, a nonsteroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets in matrix form were prepared by using extrusion/spheronization method. The optimized pelletization method revealed that extrusion using 1 mm sieve plate and spheronization friction disc of 2mm carried out at 700 rpm for 5-10 minutes resulted in good spherical pellets and uniformity in size. Evaluated core pellets were coated with polymer Eudragit® RS 30D on Fluid bed coater to achieve a sustainable release for 12 hours. Ketoprofen as like other NSAID have been reported for gastric mucosal irritation so a pH responsive barrier coat of Eudragit L®100-55 was employed on a pan coater for abstaining release in acidic media. The formulated pellets were characterized for shape and size uniformity, friability, surface morphology studies. The particle size of core and polymer coated pellets were found to be in the range of 0.95-1.2 mm and 1.32-1.51 mm respectively. The pellets were spherical in shape with smooth texture and uniformity in size. In-vitro dissolution tests were carried out for pellets in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the ketoprofen from formulated pellets was established in pH 1.2 for a period of 2 h, followed by pH 7.5 for rest of the study. The study concluded that the formulated multiparticulate dosage form of ketoprofen was able to relieve symptoms of rheumatoid arthritis.

Comparative in vitro dissolution and in vivo bioequivalence of two diclofenac enteric coated formulations

2012 ◽  
Vol 61 (10) ◽  
pp. 566-570 ◽  
Author(s):  
Saeed Basmenji ◽  
Hadi Valizadeh ◽  
Parvin Zakeri-Milani
Keyword(s):  
In Vitro Dissolution ◽  
Enteric Coated

In vitro dissolution profiles of enteric coated microsphere pancreatin preparations at different pH values

1995 ◽  
Vol 108 (4) ◽  
pp. A356
Author(s):  
KH Gan ◽  
WP Geus ◽  
HGM Heijerman ◽  
W Bakker ◽  
CBHW Lamers
Keyword(s):  
In Vitro Dissolution ◽  
Ph Values ◽  
Enteric Coated
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