Diffusion of Sodium Salicylate and Salicylic Acid within Hydrophilic Ointments

1962 ◽  
Vol 51 (7) ◽  
pp. 668-671 ◽  
Author(s):  
J.A. Wood ◽  
L. Wait Rising ◽  
Nathan A. Hall
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate

scholarly journals Particle Properties of Spray-Dried and Agglomerated Products of Salicylic Acid and Sodium Salicylate

1972 ◽  
Vol 21 (225) ◽  
pp. 557-561
Author(s):  
Yoshiaki KAWASHIMA ◽  
Keiichi MATSUDA ◽  
Yoshiharu YASUE ◽  
Hideo TAKENAKA
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate ◽  
Particle Properties ◽  
Spray Dried

Comparison of Availability of Ions from Sodium Salicylate and Salicylic Acid Tablets

1974 ◽  
Vol 63 (3) ◽  
pp. 438-440 ◽  
Author(s):  
T.E. Needham ◽  
L.A. Luzzi ◽  
W.D. Mason
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate

scholarly journals Pharmacokinetics of Salicylic Acid Following Intravenous and Oral Administration of Sodium Salicylate in Sheep

2018 ◽  
Author(s):  
Shashwati Mathurkar ◽  
Preet Singh ◽  
Kavitha Kongara ◽  
Paul Chambers
Keyword(s):  
Salicylic Acid ◽  
Oral Administration ◽  
High Performance ◽  
Sodium Salicylate ◽  
Elimination Half ◽  
Healthy Sheep ◽  
Array Detection ◽  
Intravenous And Oral Administration ◽  
Effective Plasma Concentration ◽  
Different Doses

The pharmacokinetics of salicylic acid (SA) in sheep was evaluated following intravenous (IV) and oral administration of sodium salicylate (sodium salt of salicylic acid) at different doses. Six healthy sheep were administered sodium salicylate (SS) IV at doses of 10, 50, 100 and 200 mg/kg body weight and another six sheep were drenched with 100 and 200 mg/kg of SS orally. Both studies were randomised crossover trials. A one-week washout period between each treatment was allowed in both studies. Blood samples were collected at 0, 15, 30 minutes and 1, 2, 4 and 6 hours after IV and oral SS administrations. Plasma SA concentrations were determined using high performance liquid chromatography with diode array detection method. Pharmacokinetic variables were calculated in a non-compartmental model. The elimination half-life (T1/2 el) of SA after IV administration of 200 mg/kg SS was 1.16 ± 0.32 hours. Mean bioavailability of SA was 64%, and mean T1/2 el was 1.90 ± 0.35 hours, after 200 mg/kg of oral SS. The minimum plasma SA concentration (16.8 µg/mL) required to produce analgesia in humans was achieved after IV administration of 100 and 200 mg/kg SS in sheep for about 0.17 hour in this study. Experiments on pharmacokinetic-pharmacodynamics modelling are required to determine the actual effective plasma concentration range of SA in sheep.

Terahertz Spectroscopic Investigation of Salicylic Acid and Sodium Salicylate

2019 ◽  
Vol 85 (6) ◽  
pp. 1143-1150 ◽  
Author(s):  
L. Ding ◽  
W.-H. Fan ◽  
C. Song ◽  
X. Chen ◽  
Z.-Y. Chen
Keyword(s):  
Salicylic Acid ◽  
Spectroscopic Investigation ◽  
Sodium Salicylate

scholarly journals Flow Properties of Fed-slurries Containing Sodium Salicylate and Salicylic Acid Particles

1973 ◽  
Vol 10 (5) ◽  
pp. 255-262
Author(s):  
Yoshiaki KAWASHIMA ◽  
Toshiko UMEMURA ◽  
Motoko CHIKAI ◽  
Hideo TAKENAKA
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate ◽  
Flow Properties

scholarly journals Salicylic Acid and Sodium Salicylate Alleviate Cadmium Toxicity to Different Extents in Maize (Zea mays L.)

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160157 ◽  
Author(s):  
Orsolya Kinga Gondor ◽  
Magda Pál ◽  
Éva Darkó ◽  
Tibor Janda ◽  
Gabriella Szalai
Keyword(s):  
Zea Mays ◽  
Salicylic Acid ◽  
Zea Mays L ◽  
Sodium Salicylate ◽  
Cadmium Toxicity

scholarly journals Pharmacokinetics of Salicylic Acid Following Intravenous and Oral Administration of Sodium Salicylate in Sheep

Animals ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 122 ◽  
Author(s):  
Shashwati Mathurkar ◽  
Preet Singh ◽  
Kavitha Kongara ◽  
Paul Chambers
Keyword(s):  
Salicylic Acid ◽  
Oral Administration ◽  
High Performance ◽  
Sodium Salicylate ◽  
Elimination Half ◽  
Healthy Sheep ◽  
Array Detection ◽  
Intravenous And Oral Administration ◽  
Effective Plasma Concentration ◽  
Different Doses

The pharmacokinetics of salicylic acid (SA) in sheep was evaluated following intravenous (IV) and oral administration of sodium salicylate (sodium salt of salicylic acid) at different doses. Six healthy sheep were administered sodium salicylate (SS) IV at doses of 10, 50, 100 and 200 mg/kg body weight and another six sheep were drenched with 100 and 200 mg/kg of SS orally. Both studies were randomised crossover trials. A one-week washout period between each treatment was allowed in both studies. Blood samples were collected at 0, 15, 30 min and 1, 2, 4 and 6 h after IV and oral SS administrations. Plasma SA concentrations were determined using high-performance liquid chromatography (HPLC) with diode array detection method. Pharmacokinetic variables were calculated in a non-compartmental model. The elimination half-life (T1/2 el) of SA after IV administration of 200 mg/kg SS was 1.16 ± 0.32 h. Mean bioavailability of SA was 64%, and mean T1/2 el was 1.90 ± 0.35 h, after 200 mg/kg of oral SS. The minimum plasma SA concentration (16.8 µg/mL) reported to produce analgesia in humans was achieved after IV administration of 100 and 200 mg/kg SS in sheep for about 0.17 h in this study. Experiments on pharmacokinetic–pharmacodynamics modelling are required to determine the actual effective plasma concentration range of SA in sheep.

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