scholarly journals Particle Properties of Spray-Dried and Agglomerated Products of Salicylic Acid and Sodium Salicylate

1972 ◽  
Vol 21 (225) ◽  
pp. 557-561
Author(s):  
Yoshiaki KAWASHIMA ◽  
Keiichi MATSUDA ◽  
Yoshiharu YASUE ◽  
Hideo TAKENAKA
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate ◽  
Particle Properties ◽  
Spray Dried

scholarly journals Inhalable Spray-Dried Chondroitin Sulphate Microparticles: Effect of Different Solvents on Particle Properties and Drug Activity

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 425 ◽  
Author(s):  
Susana Rodrigues ◽  
Ana da Costa ◽  
Noelia Flórez-Fernández ◽  
María Torres ◽  
Maria Faleiro ◽  
...  
Keyword(s):  
Spray Drying ◽  
Chondroitin Sulphate ◽  
Antitubercular Activity ◽  
Particle Fraction ◽  
First Line ◽  
Antitubercular Drugs ◽  
Particle Properties ◽  
Aerodynamic Properties ◽  
Tuberculosis Therapy ◽  
Spray Dried

Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles. In this work, we describe the production of drug-loaded chondroitin sulphate microparticles by spray-drying, testing the effect of using different solvents during the process. Full characterisation of the polymer and of the aerodynamic properties of the obtained microparticles are provided envisaging an application in inhalable tuberculosis therapy. The spray-dried microparticles successfully associated two first-line antitubercular drugs (isoniazid and rifabutin) with satisfactory production yield (up to 85%) and drug association efficiency (60%–95%). Ethanol and HCl were tested as co-solvents to aid the solubilisation of rifabutin and microparticles produced with the former generally revealed the best features, presenting a better ability to sustainably release rifabutin. Moreover, these presented aerodynamic properties compatible with deep lung deposition, with an aerodynamic diameter around 4 μm and fine particle fraction of approximately 44%. Finally, it was further demonstrated that the antitubercular activity of the drugs remained unchanged after encapsulation independently of the used solvent.

Comparison of Availability of Ions from Sodium Salicylate and Salicylic Acid Tablets

1974 ◽  
Vol 63 (3) ◽  
pp. 438-440 ◽  
Author(s):  
T.E. Needham ◽  
L.A. Luzzi ◽  
W.D. Mason
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate

scholarly journals Pharmacokinetics of Salicylic Acid Following Intravenous and Oral Administration of Sodium Salicylate in Sheep

2018 ◽  
Author(s):  
Shashwati Mathurkar ◽  
Preet Singh ◽  
Kavitha Kongara ◽  
Paul Chambers
Keyword(s):  
Salicylic Acid ◽  
Oral Administration ◽  
High Performance ◽  
Sodium Salicylate ◽  
Elimination Half ◽  
Healthy Sheep ◽  
Array Detection ◽  
Intravenous And Oral Administration ◽  
Effective Plasma Concentration ◽  
Different Doses

The pharmacokinetics of salicylic acid (SA) in sheep was evaluated following intravenous (IV) and oral administration of sodium salicylate (sodium salt of salicylic acid) at different doses. Six healthy sheep were administered sodium salicylate (SS) IV at doses of 10, 50, 100 and 200 mg/kg body weight and another six sheep were drenched with 100 and 200 mg/kg of SS orally. Both studies were randomised crossover trials. A one-week washout period between each treatment was allowed in both studies. Blood samples were collected at 0, 15, 30 minutes and 1, 2, 4 and 6 hours after IV and oral SS administrations. Plasma SA concentrations were determined using high performance liquid chromatography with diode array detection method. Pharmacokinetic variables were calculated in a non-compartmental model. The elimination half-life (T1/2 el) of SA after IV administration of 200 mg/kg SS was 1.16 ± 0.32 hours. Mean bioavailability of SA was 64%, and mean T1/2 el was 1.90 ± 0.35 hours, after 200 mg/kg of oral SS. The minimum plasma SA concentration (16.8 µg/mL) required to produce analgesia in humans was achieved after IV administration of 100 and 200 mg/kg SS in sheep for about 0.17 hour in this study. Experiments on pharmacokinetic-pharmacodynamics modelling are required to determine the actual effective plasma concentration range of SA in sheep.

Terahertz Spectroscopic Investigation of Salicylic Acid and Sodium Salicylate

2019 ◽  
Vol 85 (6) ◽  
pp. 1143-1150 ◽  
Author(s):  
L. Ding ◽  
W.-H. Fan ◽  
C. Song ◽  
X. Chen ◽  
Z.-Y. Chen
Keyword(s):  
Salicylic Acid ◽  
Spectroscopic Investigation ◽  
Sodium Salicylate

Diffusion of Sodium Salicylate and Salicylic Acid within Hydrophilic Ointments

1962 ◽  
Vol 51 (7) ◽  
pp. 668-671 ◽  
Author(s):  
J.A. Wood ◽  
L. Wait Rising ◽  
Nathan A. Hall
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate

scholarly journals Flow Properties of Fed-slurries Containing Sodium Salicylate and Salicylic Acid Particles

1973 ◽  
Vol 10 (5) ◽  
pp. 255-262
Author(s):  
Yoshiaki KAWASHIMA ◽  
Toshiko UMEMURA ◽  
Motoko CHIKAI ◽  
Hideo TAKENAKA
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate ◽  
Flow Properties
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