Comparison of High-Throughput Biophysical Methods to Identify Stabilizing Excipients for a Model IgG2 Monoclonal Antibody: Conformational Stability and Kinetic Aggregation Measurements

2012 ◽  
Vol 101 (5) ◽  
pp. 1701-1720 ◽  
Author(s):  
Weiqiang Cheng ◽  
Sangeeta B. Joshi ◽  
Feng He ◽  
David N. Brems ◽  
Bing He ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
High Throughput ◽  
Conformational Stability

scholarly journals High-Throughput Biophysical Analysis and Data Visualization of Conformational Stability of an IgG1 Monoclonal Antibody After Deglycosylation

2013 ◽  
Vol 102 (11) ◽  
pp. 3942-3956 ◽  
Author(s):  
Mohammad A. Alsenaidy ◽  
Jae Hyun Kim ◽  
Ranajoy Majumdar ◽  
David D. Weis ◽  
Sangeeta B. Joshi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Data Visualization ◽  
High Throughput ◽  
Conformational Stability ◽  
Igg1 Monoclonal Antibody ◽  
Biophysical Analysis

scholarly journals Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro-bioreactor system

2017 ◽  
Vol 34 (1) ◽  
pp. 262-270 ◽  
Author(s):  
Sai Rashmika Velugula-Yellela ◽  
Abasha Williams ◽  
Nicholas Trunfio ◽  
Chih-Jung Hsu ◽  
Brittany Chavez ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
High Throughput ◽  
Antibody Production ◽  
Monoclonal Antibody Production ◽  
Bioreactor System

High-throughput determination of free d-aspartic acid in mammals by enzyme immunoassay using specific monoclonal antibody

2006 ◽  
Vol 357 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Tomohiro Ohgusu ◽  
Kenji Hamase ◽  
Hiroyuki Tanaka ◽  
Yukihiro Shoyama ◽  
Kiyoshi Zaitsu
Keyword(s):  
Monoclonal Antibody ◽  
Enzyme Immunoassay ◽  
Aspartic Acid ◽  
High Throughput ◽  
Specific Monoclonal Antibody

A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells

2009 ◽  
Vol 104 (6) ◽  
pp. 1107-1120 ◽  
Author(s):  
Rachel Legmann ◽  
H. Brett Schreyer ◽  
Rodney G. Combs ◽  
Ellen L. McCormick ◽  
A. Peter Russo ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
High Throughput ◽  
Antibody Production ◽  
Cho Cells ◽  
Monoclonal Antibody Production ◽  
Scale Down

High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody

2015 ◽  
Vol 113 (6) ◽  
pp. 1273-1283 ◽  
Author(s):  
Matthew G. Petroff ◽  
Haiying Bao ◽  
John P. Welsh ◽  
Miranda van Beuningen - de Vaan ◽  
Jennifer M. Pollard ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
High Throughput ◽  
Formal Process ◽  
Process Characterization ◽  
Potential Use

Local Dynamics and Their Alteration by Excipients Modulate the Global Conformational Stability of an lgG1 Monoclonal Antibody

2012 ◽  
Vol 101 (12) ◽  
pp. 4444-4457 ◽  
Author(s):  
Santosh V. Thakkar ◽  
Jae Hyun Kim ◽  
Hardeep S. Samra ◽  
Hasige A. Sathish ◽  
Steven M. Bishop ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Conformational Stability ◽  
Local Dynamics

scholarly journals Monoclonal antibody higher order structure analysis by high throughput protein conformational array

mAbs ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 397-405 ◽  
Author(s):  
Yuanli Song ◽  
Deqiang Yu ◽  
Mukesh Mayani ◽  
Nesredin Mussa ◽  
Zheng Jian Li
Keyword(s):  
Monoclonal Antibody ◽  
Structure Analysis ◽  
High Throughput ◽  
Higher Order ◽  
Order Structure
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