Surface-Active Derivative of Inulin (Inutec® SP1) Is a Superior Carrier for Solid Dispersions with a High Drug Load

2011 ◽  
Vol 100 (6) ◽  
pp. 2333-2342 ◽  
Author(s):  
Parinda Srinarong ◽  
Suvi Hämäläinen ◽  
Marinella R. Visser ◽  
Wouter L.J. Hinrichs ◽  
Jarkko Ketolainen ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Drug Load ◽  
High Drug ◽  
Active Derivative ◽  
Surface Active

scholarly journals SOLID DISPERSIONS: A METHOD TO IMPROVE BIOAVAILABILITY OF ORAL DRUG DOSAGE FORM

2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Ritika Puri ◽  
Manisha Bhatti
Keyword(s):  
Solid Dispersion ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Systemic Circulation ◽  
Drug Dosage ◽  
Oral Drug ◽  
Surface Active Agents ◽  
Drug Dosage Form ◽  
Surface Active ◽  
Biopharmaceutical Classification System

Presently only few percent of drugs having high aqueous solubility, Number of drugs are belonging to biopharmaceutical classification system class II that means possessing  poor aqueous solubility  eventually  results in low level of drug in systemic circulation. To overcome this problem, various strategies have been come out into notion such as self emulsifying drug delivery system solid dispersions, use of surface active agents, complex formation. Solid dispersions is found to be promising approach to increase bioavailability by use of various polymers. This review focuses on the mechanism of drug release from solid dispersion with its method of preparation and applications. Key words: dissolution, particle size, solid dispersion

scholarly journals Influence of Particle Size and Drug Load on Amorphous Solid Dispersions Containing pH-Dependent Soluble Polymers and the Weak Base Ketoconazole

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Marius Monschke ◽  
Kevin Kayser ◽  
Karl G. Wagner
Keyword(s):  
Particle Size ◽  
Phase Separation ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Drug Load ◽  
Soluble Polymers ◽  
Eudragit L100 ◽  
Ph Dependent ◽  
Hot Melt

AbstractAmong the great number of poorly soluble drugs in pharmaceutical development, most of them are weak bases. Typically, they readily dissolve in an acidic environment but are prone to precipitation at elevated pH. This was aimed to be counteracted by the preparation of amorphous solid dispersions (ASDs) using the pH-dependent soluble polymers methacrylic acid ethylacrylate copolymer (Eudragit L100–55) and hydroxypropylmethylcellulose acetate succinate (HPMCAS) via hot-melt extrusion. The hot-melt extruded ASDs were of amorphous nature and single phased with the presence of specific interactions between drug and polymer as revealed by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FT-IR). The ASDs were milled and classified into six particle size fractions. We investigated the influence of particle size, drug load, and polymer type on the dissolution performance. The best dissolution performance was achieved for the ASD made from Eudragit L100–55 at a drug load of 10%, whereby the dissolution rate was inversely proportional to the particle size. Within a pH-shift dissolution experiment (from pH 1 to pH 6.8), amorphous-amorphous phase separation occurred as a result of exposure to acidic medium which caused markedly reduced dissolution rates at subsequent higher pH values. Phase separation could be prevented by using enteric capsules (Vcaps Enteric®), which provided optimal dissolution profiles for the Eudragit L100–55 ASD at a drug load of 10%.

Removal of Cd2+, Zn2+, and Sr2+ by Ion Flotation, Using a Surface-Active Derivative of DTPA (C12-DTPA)

2017 ◽  
Vol 56 (38) ◽  
pp. 10605-10614 ◽  
Author(s):  
Alireza Eivazihollagh ◽  
Javier Tejera ◽  
Ida Svanedal ◽  
Håkan Edlund ◽  
Angeles Blanco ◽  
...  
Keyword(s):  
Ion Flotation ◽  
Active Derivative ◽  
Surface Active

Application of a Mixture Experimental Design in the Optimization of a Self‐Emulsifying Formulation with a High Drug Load

2004 ◽  
Vol 9 (3) ◽  
pp. 301-309 ◽  
Author(s):  
Ping Gao ◽  
Martha J. Witt ◽  
Roy J. Haskell ◽  
Kathryn M. Zamora ◽  
John R. Shifflett
Keyword(s):  
Experimental Design ◽  
Drug Load ◽  
High Drug ◽  
Mixture Experimental Design

Development of a high drug load tablet formulation based on assessment of powder manufacturability: Moving towards quality by design

2009 ◽  
Vol 98 (1) ◽  
pp. 239-247 ◽  
Author(s):  
Changquan Calvin Sun ◽  
Hao Hou ◽  
Ping Gao ◽  
Chandra Ma ◽  
Cesar Medina ◽  
...  
Keyword(s):  
Quality By Design ◽  
Tablet Formulation ◽  
Drug Load ◽  
High Drug
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