Development of a high drug load tablet formulation based on assessment of powder manufacturability: Moving towards quality by design

2009 ◽  
Vol 98 (1) ◽  
pp. 239-247 ◽  
Author(s):  
Changquan Calvin Sun ◽  
Hao Hou ◽  
Ping Gao ◽  
Chandra Ma ◽  
Cesar Medina ◽  
...  
Keyword(s):  
Quality By Design ◽  
Tablet Formulation ◽  
Drug Load ◽  
High Drug

Surface-Active Derivative of Inulin (Inutec® SP1) Is a Superior Carrier for Solid Dispersions with a High Drug Load

2011 ◽  
Vol 100 (6) ◽  
pp. 2333-2342 ◽  
Author(s):  
Parinda Srinarong ◽  
Suvi Hämäläinen ◽  
Marinella R. Visser ◽  
Wouter L.J. Hinrichs ◽  
Jarkko Ketolainen ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Drug Load ◽  
High Drug ◽  
Active Derivative ◽  
Surface Active

Application of a Mixture Experimental Design in the Optimization of a Self‐Emulsifying Formulation with a High Drug Load

2004 ◽  
Vol 9 (3) ◽  
pp. 301-309 ◽  
Author(s):  
Ping Gao ◽  
Martha J. Witt ◽  
Roy J. Haskell ◽  
Kathryn M. Zamora ◽  
John R. Shifflett
Keyword(s):  
Experimental Design ◽  
Drug Load ◽  
High Drug ◽  
Mixture Experimental Design

High drug load, stable, manufacturable and bioavailable fenofibrate formulations in mesoporous silica: a comparison of spray drying versus solvent impregnation methods

Drug Delivery ◽  
2014 ◽  
Vol 23 (1) ◽  
pp. 316-327 ◽  
Author(s):  
Shiqi Hong ◽  
Shoucang Shen ◽  
David Cheng Thiam Tan ◽  
Wai Kiong Ng ◽  
Xueming Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Spray Drying ◽  
Drug Load ◽  
High Drug

scholarly journals Dissolution profile of Curcumin from solid dispersion prepared at a high drug load of Curcumin using Poloxamer 407 as the carrier

2021 ◽  
pp. 77-80
Author(s):  
Dewi Setyaningsih ◽  
Yustina Sri Hartini ◽  
Christine Patramurti ◽  
Sastira Putri ◽  
Yosi Bayu Murti
Keyword(s):  
Solid Dispersion ◽  
Poloxamer 407 ◽  
Dissolution Profile ◽  
Solvent Evaporation Method ◽  
Drug Load ◽  
High Drug ◽  
Control Drug ◽  
Dispersion Formula ◽  
Dissolution Behaviour ◽  
Dissolution Efficiency

Introduction: Curcumin, a BCS II drug, suffers from poor bioavailability. Increasing curcumin dissolution is a way to increase its bioavailability. Solid dispersion formulation can be used to improve curcumin dissolution. However, the successful curcumin solid dispersion is limited to a relatively low drug load (< 20%). Objective: This study aimed to investigate the dissolution behaviour of curcumin at a higher drug load (27.9%, 42.3%, and 56.6%) using a surfactant carrier of poloxamer 407. Methods: The solvent evaporation method was employed to prepare high drug load solid dispersion of curcumin. A physical mixture of the corresponding solid dispersion formulation was prepared as a control. Drug load, dissolution behaviour in 180 minutes, and dissolution efficiency (DE180) were determined. Results: The results showed that incorporating curcumin into a poloxamer 407 solid dispersion significantly improves the dissolution rate of curcumin. In the solid dispersion formula, the dissolution behaviour of curcumin was found to be carrier-dependent.

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