An Extrusion Spheronization Approach to Enable a High Drug Load Formulation of a Poorly Soluble Drug with a Low Melting Surfactant

2015 ◽  
Vol 104 (11) ◽  
pp. 3752-3759 ◽  
Author(s):  
Aditya Tatavarti ◽  
Filippos Kesisoglou
Keyword(s):  
Drug Load ◽  
High Drug ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Extrusion Spheronization

Studies on the Preparation, Characterization and Solubility of -Cyclodextrin-Roxythromycin Inclusion Complexes

2009 ◽  
Vol 2 (2) ◽  
pp. 523-530
Author(s):  
D. Nagasamy Venkatesh ◽  
S. Karthick ◽  
M. Umesh ◽  
G. Vivek ◽  
R.M. Valliappan ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Inclusion Complexes ◽  
Phase Solubility ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ir Studies ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Roxythromycin/ β-cyclodextrin (Roxy/ β-CD) dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of roxythromycin was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:1 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), X-ray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate.

Impact of Drug-Polymer Interaction in Amorphous Solid Dispersion Aiming for the Supersaturation of Poorly Soluble Drug in Biorelevant Medium

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Cassiana Mendes ◽  
Rafael G. Andrzejewski ◽  
Juliana M. O. Pinto ◽  
Leice M. R. de Novais ◽  
Andersson Barison ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Drug Polymer Interaction ◽  
Biorelevant Medium ◽  
Polymer Interaction

Multicomponent Amorphous Nanofibers Electrospun from Hot Aqueous Solutions of a Poorly Soluble Drug

2010 ◽  
Vol 27 (11) ◽  
pp. 2466-2477 ◽  
Author(s):  
Deng-Guang Yu ◽  
Li-Dong Gao ◽  
Kenneth White ◽  
Christopher Branford-White ◽  
Wei-Yue Lu ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives

2012 ◽  
Vol 45 (3) ◽  
pp. 235-250 ◽  
Author(s):  
Stephen T. Buckley ◽  
Sarah M. Fischer ◽  
Gert Fricker ◽  
Martin Brandl
Keyword(s):  
In Vitro Models ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Solubilization behavior of a poorly soluble drug under combined use of surfactants and cosolvents

2006 ◽  
Vol 28 (1-2) ◽  
pp. 7-14 ◽  
Author(s):  
Kohsaku Kawakami ◽  
Naohiko Oda ◽  
Kyoko Miyoshi ◽  
Takeshi Funaki ◽  
Yasuo Ida
Keyword(s):  
Combined Use ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Investigating the solubilization effect of oxcarbazepine by forming cocrystals

CrystEngComm ◽  
2019 ◽  
Vol 21 (32) ◽  
pp. 4718-4729
Author(s):  
Xiangrong Li ◽  
Guojia Yu ◽  
Xinjian Chen ◽  
Lichao He ◽  
Zhiyong Zhou ◽  
...  
Keyword(s):  
Poorly Soluble ◽  
Poorly Soluble Drug

Oxcarbazepine (OXCBZ) is a poorly soluble drug that can't form a salt. The apparent solubilities of the OXCBZ–OA and OXCBZ–2,5-DHBA cocrystals increased approximately 2.6 and 4.7 times of that of OXCBZ.

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