Application of Melt Granulation Technology Using Twin-screw Extruder in Development of High-dose Modified-Release Tablet Formulation

2011 ◽  
Vol 100 (5) ◽  
pp. 1923-1934 ◽  
Author(s):  
Madhav Vasanthavada ◽  
Yanfeng Wang ◽  
Thomas Haefele ◽  
Jay P. Lakshman ◽  
Manisha Mone ◽  
...  
Keyword(s):  
Tablet Formulation ◽  
High Dose ◽  
Twin Screw Extruder ◽  
Modified Release ◽  
Screw Extruder ◽  
Twin Screw ◽  
Granulation Technology ◽  
Melt Granulation ◽  
Release Tablet

scholarly journals Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Rajat Radhakrishna Rao ◽  
Abhijeet Pandey ◽  
Aswathi R. Hegde ◽  
Vijay Induvadan Kulkarni ◽  
Chetan Chincholi ◽  
...  
Keyword(s):  
Process Analytical Technology ◽  
Twin Screw Extruder ◽  
Continuous Manufacturing ◽  
Screw Extruder ◽  
Solid Dosage ◽  
Regulatory Standards ◽  
Technology Applications ◽  
Twin Screw ◽  
Extrusion Technology ◽  
Granulation Technology

AbstractIn order to be at pace with the market requirements of solid dosage forms and regulatory standards, a transformation towards systematic processing using continuous manufacturing (CM) and automated model-based control is being thought through for its fundamental advantages over conventional batch manufacturing. CM eliminates the key gaps through the integration of various processes while preserving quality attributes via the use of process analytical technology (PAT). The twin screw extruder (TSE) is one such equipment adopted by the pharmaceutical industry as a substitute for the traditional batch granulation process. Various types of granulation techniques using twin screw extrusion technology have been explored in the article. Furthermore, individual components of a TSE and their conjugation with PAT tools and the advancements and applications in the field of nutraceuticals and nanotechnology have also been discussed. Thus, the future of granulation lies on the shoulders of continuous TSE, where it can be coupled with computational mathematical studies to mitigate its complications.

Hot-Melt Granulation in a Twin Screw Extruder: Effects of Processing on Formulations with Caffeine and Ibuprofen

2013 ◽  
Vol 102 (12) ◽  
pp. 4330-4336 ◽  
Author(s):  
Sharleen Weatherley ◽  
B.O. MU ◽  
Michael R. Thompson ◽  
Paul J. Sheskey ◽  
Kevin P. O'Donnell
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Twin Screw ◽  
Hot Melt Granulation ◽  
Hot Melt ◽  
Melt Granulation

Melt granulation using a twin-screw extruder: A case study

2006 ◽  
Vol 326 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Barbara Van Melkebeke ◽  
Brenda Vermeulen ◽  
Chris Vervaet ◽  
Jean Paul Remon
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Twin Screw ◽  
Melt Granulation

Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation

2014 ◽  
Vol 463 (1) ◽  
pp. 89-97 ◽  
Author(s):  
David Cheng Thiam Tan ◽  
William Wei Lim Chin ◽  
En Hui Tan ◽  
Shiqi Hong ◽  
Wei Gu ◽  
...  
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Release Rates ◽  
Twin Screw ◽  
Melt Granulation

Reactive Blending in a Twin Screw Extruder

1996 ◽  
Vol 11 (2) ◽  
pp. 139-146 ◽  
Author(s):  
A. De Loor ◽  
P. Cassagnau ◽  
A. Michel ◽  
L. Delamare ◽  
B. Vergnes
Keyword(s):  
Twin Screw Extruder ◽  
Reactive Blending ◽  
Screw Extruder ◽  
Twin Screw
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