Lyophilization Cycle Development for a High-Concentration Monoclonal Antibody Formulation Lacking a Crystalline Bulking Agent

2007 ◽  
Vol 96 (6) ◽  
pp. 1598-1608 ◽  
Author(s):  
James D. Colandene ◽  
Linda M. Maldonado ◽  
Alma T. Creagh ◽  
John S. Vrettos ◽  
Kenneth G. Goad ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bulking Agent ◽  
High Concentration

scholarly journals High concentration tangential flow ultrafiltration of stable monoclonal antibody solutions with low viscosities

2016 ◽  
Vol 508 ◽  
pp. 113-126 ◽  
Author(s):  
Jessica J. Hung ◽  
Ameya U. Borwankar ◽  
Barton J. Dear ◽  
Thomas M. Truskett ◽  
Keith P. Johnston
Keyword(s):  
Monoclonal Antibody ◽  
High Concentration ◽  
Tangential Flow

A Formulation Development Approach to Identify and Select Stable Ultra–High-Concentration Monoclonal Antibody Formulations With Reduced Viscosities

2017 ◽  
Vol 106 (11) ◽  
pp. 3230-3241 ◽  
Author(s):  
Neal Whitaker ◽  
Jian Xiong ◽  
Samantha E. Pace ◽  
Vineet Kumar ◽  
C. Russell Middaugh ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Formulation Development ◽  
High Concentration ◽  
Development Approach

Characterizing protein–protein-interaction in high-concentration monoclonal antibody systems with the quartz crystal microbalance

2017 ◽  
Vol 19 (48) ◽  
pp. 32698-32707 ◽  
Author(s):  
Josef Hartl ◽  
Astrid Peschel ◽  
Diethelm Johannsmann ◽  
Patrick Garidel
Keyword(s):  
Monoclonal Antibody ◽  
Quartz Crystal Microbalance ◽  
Protein Interaction ◽  
Quartz Crystal ◽  
Therapeutic Antibodies ◽  
High Concentration ◽  
Concentrated Solutions ◽  
Protein Protein Interaction

Making use of a quartz crystal microbalance, concentrated solutions of therapeutic antibodies were studied with respect to their behavior under shear excitation with frequencies in the MHz range.

scholarly journals Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation

mAbs ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1940666
Author(s):  
Jack E. Bramham ◽  
Stephanie A. Davies ◽  
Adrian Podmore ◽  
Alexander P. Golovanov
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
High Concentration ◽  
Antibody Solution ◽  
Liquid Liquid Phase Separation
Sign in / Sign up

Export Citation Format

Share Document