Biophysical Characterization of Insoluble Aggregates of a Multi-Domain Protein: An Insight into the Role of the Various Domains

2005 ◽  
Vol 94 (9) ◽  
pp. 2069-2083 ◽  
Author(s):  
Pierre O. Souillac
Keyword(s):  
Biophysical Characterization ◽  
Domain Protein ◽  
Insight Into

Histolocalization and physico-chemical characterization of dihydrochalcones: Insight into the role of apple major flavonoids

2013 ◽  
Vol 90 ◽  
pp. 78-89 ◽  
Author(s):  
Matthieu Gaucher ◽  
Thomas Dugé de Bernonville ◽  
David Lohou ◽  
Sylvain Guyot ◽  
Thomas Guillemette ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Physico Chemical ◽  
Insight Into

scholarly journals The pathophysiology of sepsis—2021 update: Part 1, immunology and coagulopathy leading to endothelial injury

2021 ◽  
Author(s):  
Judith Jacobi
Keyword(s):  
Treatment Options ◽  
Endothelial Injury ◽  
Coagulation Cascade ◽  
Secondary Infections ◽  
Sepsis And Septic Shock ◽  
Risk And Benefit ◽  
Insight Into ◽  
Related Mortality

Abstract Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose To provide an overview of current literature on the pathophysiology of sepsis, with a focus on mediators of endothelial injury and organ dysfunction. Summary Sepsis is a dysregulated response to infection that triggers cascades of interconnected systems. Sepsis has been a significant cause of mortality worldwide, and the recent viral pandemic that may produce severe sepsis and septic shock has been a major contributor to sepsis-related mortality. Understanding of the pathophysiology of sepsis has changed dramatically over the last several decades. Significant insight into the components of the inflammatory response that contribute to endothelial injury and trigger coagulation pathways has been achieved. Similarly, characterization of anti-inflammatory pathways that may lead to secondary infections and poor outcome has illustrated opportunities for improved therapies. Description of an increasing number of important mediators and pathways has occurred and may point the way to novel therapies to address immune dysregulation. Pharmacists will need a fundamental understanding of the overlapping pathways of the immune response to fully prepare for use of novel treatment options. While pharmacists typically understand coagulation cascade how to utilize anticoagulants, the issues in sepsis related coagulopathy and role of mediators such as cytokines and complement and role of activated platelets and neutrophils require a different perspective. Conclusion Pharmacists can benefit from understanding both the cellular and organ system issues in sepsis to facilitate assessment of potential therapies for risk and benefit.

An Insight into the Biophysical Characterization of Insoluble Collagen Aggregates: Implication for Arthritis

2014 ◽  
Vol 24 (5) ◽  
pp. 1423-1431 ◽  
Author(s):  
Samreen Amani ◽  
Anas Shamsi ◽  
Gulam Rabbani ◽  
Aabgeena Naim
Keyword(s):  
Biophysical Characterization ◽  
Insoluble Collagen ◽  
Insight Into

scholarly journals The Role of Hydraulic Hysteresis on the Hydrological Response of Pyroclastic Silty Covers

Water ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 628 ◽  
Author(s):  
Guido Rianna ◽  
Luca Comegna ◽  
Luca Pagano ◽  
Luciano Picarelli ◽  
Alfredo Reder
Keyword(s):  
Slope Failure ◽  
Hysteretic Behavior ◽  
Recent Experience ◽  
Hydrological Response ◽  
Hydraulic Hysteresis ◽  
The Stability ◽  
Hydrological Effects ◽  
Insight Into

A significant part of the recent geotechnical literature concerning pyroclastic soils is focused on the characterization of the hydrological effects of precipitations and their implications for the stability conditions of unsaturated sloping covers. Recent experience shows that suction-induced strength reduction is influenced by various factors including hydraulic hysteresis. A deeper insight into the hysteretic water retention behavior of these materials and its effects upon their response to dry/wetting conditions is a major goal of this paper, which exploits the data provided by the monitoring of a volcanic ash. Based on the parameters retrieved from data calibration, the hydrological response of a virtual slope subject to one-dimensional rainfall infiltration is investigated by numerical analyses and compared with the results obtained through the usually adopted non-hysteretic approaches. The analysis demonstrates that considering the hysteretic behavior may be crucial for a proper evaluation of the conditions leading to slope failure.

scholarly journals Characterization of vegetative inflorescence (mc-vin) mutant provides new insight into the role of MACROCALYX in regulating inflorescence development of tomato

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Fernando J. Yuste-Lisbona ◽  
Muriel Quinet ◽  
Antonia Fernández-Lozano ◽  
Benito Pineda ◽  
Vicente Moreno ◽  
...  
Keyword(s):  
Inflorescence Development ◽  
Insight Into
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