scholarly journals Acceleration of bone regeneration of horizontal bone defect in rats using collagen‐binding basic fibroblast growth factor combined with collagen scaffolds

2019 ◽  
Vol 90 (9) ◽  
pp. 1043-1052 ◽  
Author(s):  
Shin Nakamura ◽  
Takashi Ito ◽  
Kentaro Okamoto ◽  
Takehiko Mima ◽  
Kentaro Uchida ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Fibroblast Growth Factor ◽  
Bone Defect ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Collagen Scaffolds ◽  
Collagen Binding

Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor

Biomaterials ◽  
2011 ◽  
Vol 32 (32) ◽  
pp. 8172-8181 ◽  
Author(s):  
Xin’an Li ◽  
Haixiang Sun ◽  
Nacheng Lin ◽  
Xianglin Hou ◽  
Jingmei Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Collagen Scaffolds ◽  
Collagen Binding

Bladder Regeneration by Collagen Scaffolds With Collagen Binding Human Basic Fibroblast Growth Factor

2010 ◽  
Vol 183 (6) ◽  
pp. 2432-2439 ◽  
Author(s):  
Wei Chen ◽  
Chunying Shi ◽  
Shanhong Yi ◽  
Bing Chen ◽  
Weiwei Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Collagen Scaffolds ◽  
Collagen Binding ◽  
Bladder Regeneration

Potential efficacy of basic fibroblast growth factor incorporated in biodegradable hydrogels for skull bone regeneration

1997 ◽  
Vol 86 (5) ◽  
pp. 871-875 ◽  
Author(s):  
Keisuke Yamada ◽  
Yasuhiko Tabata ◽  
Kazuo Yamamoto ◽  
Susumu Miyamoto ◽  
Izumi Nagata ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibrous Tissue ◽  
Rabbit Model ◽  
Fibroblast Growth ◽  
Skull Defect ◽  
Content Type

✓ Biodegradable gelatin hydrogels incorporating basic fibroblast growth factor (bFGF) were evaluated for their efficacy in bone regeneration using a rabbit model. Hydrogels with water contents of 85% and 98% were prepared using chemical crosslinking of gelatin with an isoelectric point of 4.9 in aqueous solution and, after freeze drying, were impregnated with an aqueous solution of bFGF to obtain bFGF-incorporated gelatin hydrogels. When they were implanted into bone defects measuring 6 mm in diameter in rabbit skulls (six animals/group), complete closure of the defect was observed at 12 weeks after implantation, regardless of the water content of the hydrogels. In contrast, bFGF did not enhance bone regeneration when applied to the skull defect in solution with phosphate-buffered saline (PBS). Also, gelatin hydrogels lacking bFGF were not effective in inducing bone formation, with fibrous tissue growing into the defect instead, similar to the skull defect seen in control rabbits treated with PBS. This indicates that the presence of hydrogels did not interfere with bone regeneration at the skull defect, probably because of their disappearance during biodegradation. It is concluded that the gelatin hydrogel is a promising matrix for effective induction of biological activity of bFGF for bone regeneration in skull and sinus defects.

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