bladder regeneration
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2020 ◽  
Vol 9 (3) ◽  
pp. 766
Author(s):  
Ahmed Abdal Dayem ◽  
Kyeongseok Kim ◽  
Soo Bin Lee ◽  
Aram Kim ◽  
Ssang-Goo Cho

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic disease without definite etiology characterized by bladder-related pelvic pain. IC/BPS is associated with pain that negatively affects the quality of life. There are various therapeutic approaches against IC/BPS. However, no efficient therapeutic agent against IC/BPS has been discovered yet. Urothelium dysfunction is one of the key factors of IC/BPS-related pathogenicity. Stem cells, including adult stem cells (ASCs) and pluripotent stem cells (PSCs), such as embryonic stem cells (ESCs) and induced PSCs (iPSCs), possess the abilities of self-renewal, proliferation, and differentiation into various cell types, including urothelial and other bladder cells. Therefore, stem cells are considered robust candidates for bladder regeneration. This review provides a brief overview of the etiology, pathophysiology, diagnosis, and treatment of IC/BPS as well as a summary of ASCs and PSCs. The potential of ASCs and PSCs in bladder regeneration via differentiation into bladder cells or direct transplantation into the bladder and the possible applications in IC/BPS therapy are described in detail. A better understanding of current studies on stem cells and bladder regeneration will allow further improvement in the approaches of stem cell applications for highly efficient IC/BPS therapy.


2019 ◽  
Vol 25 (17-18) ◽  
pp. 1289-1299 ◽  
Author(s):  
Chunxiang Feng ◽  
Chang Liu ◽  
Shiliang Liu ◽  
Zhixian Wang ◽  
Kai Yu ◽  
...  

2019 ◽  
Vol 85 ◽  
pp. 131-141 ◽  
Author(s):  
Ying Wang ◽  
Shukui Zhou ◽  
Ranxing Yang ◽  
Qingsong Zou ◽  
Kaile Zhang ◽  
...  

Author(s):  
Farshid Sefat ◽  
Tehmeena Israr Raja ◽  
Zoha Salehi Moghadam ◽  
Peiman Brouki Milan ◽  
Ali Samadikuchaksaraei ◽  
...  
Keyword(s):  

2018 ◽  
Vol 107 (6) ◽  
pp. 1960-1969 ◽  
Author(s):  
Ding Xia ◽  
Qing Yang ◽  
Kar‐Ming Fung ◽  
Rheal A. Towner ◽  
Nataliya Smith ◽  
...  

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Marta Pokrywczynska ◽  
Arkadiusz Jundzill ◽  
Marta Rasmus ◽  
Jan Adamowicz ◽  
Daria Balcerczyk ◽  
...  

2018 ◽  
Vol 115 (33) ◽  
pp. 8394-8399 ◽  
Author(s):  
Diya B. Joseph ◽  
Anoop S. Chandrashekar ◽  
Lisa L. Abler ◽  
Li-Fang Chu ◽  
James A. Thomson ◽  
...  

The bladder’s remarkable regenerative capacity had been thought to derive exclusively from its own progenitors. While examining consequences of DNA methyltransferase 1 (Dnmt1) inactivation in mouse embryonic bladder epithelium, we made the surprising discovery that Wolffian duct epithelial cells can support bladder regeneration. Conditional Dnmt1 inactivation in mouse urethral and bladder epithelium triggers widespread apoptosis, depletes basal and intermediate bladder cells, and disrupts uroplakin protein expression. These events coincide with Wolffian duct epithelial cell recruitment into Dnmt1 mutant urethra and bladder where they are reprogrammed to express bladder markers, including FOXA1, keratin 5, P63, and uroplakin. This is evidence that Wolffian duct epithelial cells are summoned in vivo to replace damaged bladder epithelium and function as a reservoir of cells for bladder regeneration.


2018 ◽  
Vol 19 (6) ◽  
pp. 1796 ◽  
Author(s):  
Ángel Serrano-Aroca ◽  
César Vera-Donoso ◽  
Victoria Moreno-Manzano
Keyword(s):  

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
MARIA JOSE MORERA ESTEVE ◽  
Mara Mellado-Lopez ◽  
Jeronimo Forteza ◽  
Victoria Moreno-Manzano ◽  
Cesar David Vera-Donoso

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